Explore the vast range of titles available.

Background: A British randomised study of gemcitabine plus cisplatin (GC) combination showed promising results in biliary tract cancer (BTC) patients. In our study, we evaluated the efficacy and safety of this combination compared with gemcitabine alone (G) in Japanese BTC patients. Methods: Overall, 84 advanced BTC patients were randomised to either cisplatin 25 mg m −2 plus gemcitabine 1000 mg m −2 on days 1, 8 of a 21-day cycle (GC-arm), or single-agent gemcitabine 1000 mg m −2 on days 1, 8 and 15 of a 28-day cycle (G-arm). Treatments were repeated for at least 12 weeks until disease progression or unacceptable toxicity occurred, up to a maximum of 48 weeks. Results: A total of 83 patients were included in the analysis. For the GC and G-arms, respectively, the 1-year survival rate was 39.0 vs 31.0%, median survival time 11.2 vs 7.7 months, median progression-free survival time 5.8 vs 3.7 months and overall response rate 19.5 vs 11.9%. The most common grade 3 or 4 toxicities (GC-arm/G-arm) were neutropenia (56.1%/38.1%), thrombocytopenia (39.0%/7.1%), leukopenia (29.3%/19.0%), haemoglobin decrease (36.6%/16.7%) and γ -GTP increase (29.3%/35.7%). Conclusions: Gemcitabine plus cisplatin combination therapy was found to be effective and well tolerated, suggesting that it could also be a standard regimen for Japanese patients.

Ti 2 O 3 exhibits unique metal–insulator transition (MIT) at ~ 450 K over a wide temperature range of ~ 150 K. The close relationship between MIT and crystal deformation has been proposed. However, as physical properties are governed by the thermodynamic equilibrium in bulk systems, conducting experimental studies under different lattice deformations remains challenging. Epitaxial thin films can offer high flexibility to accommodate adaptive crystal lattices and provide efficient platforms for investigating the MIT. In this study, we report the synthesis of corundum-type Ti 2 O 3 films on various growth temperatures. We found that the metallic ground states appeared in the films grown at low temperatures. The electronic ground states were further investigated by the electronic-structure calculations. Results suggest that the electrical properties of Ti 2 O 3 films were governed by the c / a ratio of the crystal structure, and the absence of the MIT was attributed to the lattice deformation characterized by an elongated c lattice constant.

The crystal and magnetic structure characterization of geometrically distorted PbCu3TeO7 with S=1/2 Cu2+ spins forming a staircase kagome lattice was investigated using x-ray and neutron diffraction on a powder sample. The distorted kagome lattice of antiferromagnet PbCu3TeO7 exhibits a quasi-two-dimensional spin network. The x-ray diffraction data show that PbCu3TeO7 crystallizes in the orthorhombic system in the space group Pnma (No. 62). The lattice parameters a = 10.488(1) Å, b = 6.353(1) Å, and c = 8.814(2) Å. Our temperature-dependent x-ray diffraction data show that there is no structure phase transition between 12 and 298 K. From our powder neutron diffraction data at 2 K, we observed two distinct magnetic Bragg peaks at low angles, confirming the magnetic transition to the ordered state at low temperatures. In previous work, the ordering vector for the magnetic structure was determined using simulations to be (0,1/3,0). However, in this work, we found that based on the neutron diffraction data the ordering vector is in fact (0,1/3,1/3). The magnetic structure of PbCu3TeO7 exhibiting an antiferromagnet with noncollinear spin order is proposed.

Polarised neutron scattering is the method of choice to study magnetism in condensed matter. Polarised neutrons are typically very low in flux, and complex experimental configurations further reduce the count rate. Neutron polarisation corrections would therefore be needed. Here we analytically derive formulae of the corrected partial differential scattering cross-sections. The analytical method is designed for the longitudinal polarisation analysis, and the correction generally holds for time-independent polarised neutrons with a triple-axis spectrometer. We then apply the correction to recent results of our P x experiment on Y 3 Fe 5 O 12 . Although there is a difficulty with the experimental determination of inefficiency parameters of neutron spin polarisers and flippers, the correction appears to work properly.

We have investigated the classical and quantum correlations of a quantum field in the inflationary universe using a particle detector model. We have found that the entanglement between two comoving detectors becomes zero after their physical separation exceeds the Hubble horizon. We have also found that the quantum discord, which is defined as the quantum part of total correlation, approaches zero on the super horizon scale.

Topological defects are found ubiquitously in various kinds of matter, such as vortices in type-II superconductors, and magnetic skyrmions in chiral ferromagnets. While knowledge on the static behavior of magnetic skyrmions is accumulating steadily, their dynamics under forced flow is still a widely open issue. Here, we report the deformation of the moving magnetic skyrmion lattice in MnSi under electric current flow observed using small-angle neutron scattering. A spatially inhomogeneous rotation of the skyrmion lattice, with an inverse rotation sense for opposite sample edges, is observed for current densities greater than a threshold value j t  ~ 1 MA m − 2 (10 6 A m − 2 ). Our result show that skyrmion lattices under current flow experience significant friction near the sample edges due to pinning, this being a critical effect that must be considered for anticipated skyrmion-based applications at the nanoscale. Magnetic skyrmions are topological objects that have been recently extensively studied for their particular characteristics and a view to be used in spintronics devices. The authors present a Small Angle Neutron Scattering study of the deformation of magnetic skyrmion lattice propelled by an electric current and find that the skyrmions experience frictional movement at the edges of their sample providing better understanding of the motion of skyrmions.

Background NK105 is a novel nanoparticle drug delivery formulation that encapsulates paclitaxel (PTX) in polymeric micelles. We conducted an open-label phase III non-inferiority trial to compare the efficacy and safety of NK105 and PTX in metastatic or recurrent breast cancer. Methods Patients were randomly assigned in a 1:1 ratio to receive either NK105 (65 mg/m 2 ) or PTX (80 mg/m 2 ) on days 1, 8 and 15 of a 28-day cycle. The primary endpoint was progression-free survival (PFS), with a non-inferiority margin of 1.215. Results A total of 436 patients were randomised and 211 patients in each group were included in the efficacy analysis. The median PFS was 8.4 and 8.5 months for NK105 and PTX, respectively (adjusted hazard ratio: 1.255; 95% confidence interval: 0.989–1.592). The median overall survival and overall response rates were 31.2 vs. 36.2 months and 31.6% vs. 39.0%, respectively. The two groups exhibited similar safety profiles. The incidence of peripheral sensory neuropathy (PSN) was 1.4% vs. 7.5% (≥Grade 3) for NK105 and PTX, respectively. The patient-reported outcomes of PSN were significantly favourable for NK105 ( P  < 0.0001). Conclusions The primary endpoint was not met, but NK105 had a better PSN toxicity profile than PTX. Clinical trial registration ClinicalTrials.gov: NCT01644890

High-pressure electrical resistance measurements were performed for iron-based ladder material Ba1-xCsxFe2Se3 (x = 0.25 and 0.65) using a diamond anvil cell (DAC). Recent high-pressure study revealed that iron-based ladder material BaFe2S3 exhibits an insulator-metal transition and superconductivity, and this discovery would provide important insight for understanding the mechanism of iron-based superconductors. Therefore, it is intriguing to investigate the high-pressure properties for the iron-based ladder material Ba1-xCsxFe2Se3 system. The parent compounds BaFe2Se3 and CsFe2Se3 show insulating and magnetic ordering features. For Ba1-xCsxFe2Se3 system, no magnetic ordering is observed for x = 0.25 and minimum charge gap was estimated for x = 0.65. The insulator-metal transitions are observed in both materials.

High-pressure electrical resistance measurements were performed for iron-based ladder material Ba1-xCsxFe2Se3 (x = 0.25 and 0.65) using a diamond anvil cell (DAC). Recent high-pressure study revealed that iron-based ladder material BaFe2S3 exhibits an insulator- metal transition and superconductivity, and this discovery would provide important insight for understanding the mechanism of iron-based superconductors. Therefore, it is intriguing to investigate the high-pressure properties for the iron-based ladder material Ba1-xCsxFe2Se3 system. The parent compounds BaFe2Se3 and CsFe2Se3 show insulating and magnetic ordering features. For Ba1-xCsxFe2Se3 system, no magnetic ordering is observed for x = 0.25 and minimum charge gap was estimated for x = 0.65. The insulator-metal transitions are observed in both materials.

The anomalous properties of Nambu–Goldstone bosons, found by Miransky and others in the symmetry breaking induced by a chemical potential, are attributed to the SSB of Lie and current algebras. Ferromagnetism, antiferromagnetism, and their relativistic analogs are discussed as examples.