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"Nash, Stephen"
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An anthropologist's arrival : a memoir
\"Ruth Underhill's intriguing memoir traces the story of her life, delving into the Depression, the famous anthropologists in her circle, and her fieldwork with a keen ethnographic eye. Underhill describes the Victorian society that first bound her and then ultimately enabled her success as a major figure in anthropology\"-- Provided by publisher.
Book
Ranolazine for chronic stable angina
Ranolazine is a new and unique antianginal drug that has been approved for the treatment of chronic stable angina pectoris. The drug is administered as a sustained-release formulation. Although the drug's mechanism of action has not been fully elucidated, current thinking is that ranolazine, a selective inhibitor of late sodium influx, attenuates the abnormalities of ventricular repolarisation and contractility associated with ischaemia. Three randomised trials have shown efficacy for ranolazine in increasing exercise testing or reducing anginal episodes or use of glyceryl trinitrate. Side-effects include dizziness, constipation, nausea, and the potential for prolongation of the QT
c interval. Ranolazine seems to be a safe addition to current traditional drugs for chronic stable angina, especially in aggressive multidrug regimens.
Journal Article
Stories in stone : the enchanted gem carving of Vasily Konovalenko
\"The first comprehensive treatment of the life of this poorly known Russian artist and the remarkable history of his unique, dynamic, and theatrical sculptures that stand alone in the gem carving world\"--Provided by publisher.
Book
Camel milk is a neglected source of brucellosis among rural Arab communities
The World Health Organization describes brucellosis as one of the world’s leading zoonotic diseases, with the Middle East a global hotspot.
Brucella melitensis
is endemic among livestock populations in the region, with zoonotic transmission occurring via consumption of raw milk, amongst other routes. Control is largely via vaccination of small ruminant and cattle populations. Due to sociocultural and religious influences camel milk (
camelus dromedarius)
is widely consumed raw, while milk from other livestock species is largely boiled. To investigate the potential public health impact of
Brucella
in camels we conduct a cross-sectional study in southern Jordan including 227 herds and 202 livestock-owning households. Here we show daily consumption of raw camel milk is associated with
Brucella
seropositive status among the study population, OR
adj
2.19 (95%CI 1.23–3.94) on multivariable analysis, highlighting the need for socioculturally appropriate control measures; targeted interventions among the camel reservoir being crucial for effective control.
Brucellosis is a zoonotic disease with high prevalence in the Middle East. Here the authors identify camels as an important source of brucellosis among livestock-owning households in Jordan, due to widespread consumption of raw camel milk.
Journal Article
An integrative analysis uncovers a new, pseudo-cryptic species of Amazonian marmoset (Primates: Callitrichidae: Mico) from the arc of deforestation
Amazonia has the richest primate fauna in the world. Nonetheless, the diversity and distribution of Amazonian primates remain little known and the scarcity of baseline data challenges their conservation. These challenges are especially acute in the Amazonian arc of deforestation, the 2500 km long southern edge of the Amazonian biome that is rapidly being deforested and converted to agricultural and pastoral landscapes. Amazonian marmosets of the genus
Mico
are little known endemics of this region and therefore a priority for research and conservation efforts. However, even nascent conservation efforts are hampered by taxonomic uncertainties in this group, such as the existence of a potentially new species from the Juruena–Teles Pires interfluve hidden within the
M. emiliae
epithet. Here we test if these marmosets belong to a distinct species using new morphological, phylogenomic, and geographic distribution data analysed within an integrative taxonomic framework. We discovered a new, pseudo-cryptic
Mico
species hidden within the epithet
M. emiliae
, here described and named after Horacio Schneider, the pioneer of molecular phylogenetics of Neotropical primates. We also clarify the distribution, evolutionary and morphological relationships of four other
Mico
species, bridging Linnean, Wallacean, and Darwinian shortfalls in the conservation of primates in the Amazonian arc of deforestation.
Journal Article
A Detailed Assessment of the Wave Energy Resource at the Atlantic Marine Energy Test Site
Wave characteristic assessments of wave energy test sites provide a greater understanding of prevailing wave conditions and are therefore extremely important to both wave energy test site operators and clients as they can inform wave energy converter design, optimisation, deployment, operation and maintenance. This research presents an assessment of the wave resource at the Atlantic Marine Energy Test Site (AMETS) on the west coast of Ireland based on 12-years of modelled data from January 2004 to December 2015. The primary aim is to provide an assessment of annual and seasonal wave characteristics and resource variability at the two deployment berths which comprise the site. A nested model has been developed using Simulating WAves Nearshore (SWAN) to replicate wave propagations from regional to local scale with a 0.05° resolution model covering the northeast Atlantic and a 0.0027° resolution model covering AMETS. The coarse and fine models have been extensively validated against available measured data within Irish waters. 12-year model outputs from the high resolution model were analysed to determine mean and maximum conditions and operational, high and extreme event conditions for significant wave height, energy period and power. Annual and seasonal analyses are presented. The 12-year annual mean P were 68 kW/m at Berth A (BA) and 57 kW/m at Berth B (BB). The resource shows strong seasonal and annual variations and the winter mean power levels were found to be strongly correlated with the North Atlantic Oscillation (NAO).
Journal Article
Nuclear versus mitochondrial DNA: evidence for hybridization in colobine monkeys
Background
Colobine monkeys constitute a diverse group of primates with major radiations in Africa and Asia. However, phylogenetic relationships among genera are under debate, and recent molecular studies with incomplete taxon-sampling revealed discordant gene trees. To solve the evolutionary history of colobine genera and to determine causes for possible gene tree incongruences, we combined presence/absence analysis of mobile elements with autosomal, X chromosomal, Y chromosomal and mitochondrial sequence data from all recognized colobine genera.
Results
Gene tree topologies and divergence age estimates derived from different markers were similar, but differed in placing
Piliocolobus/Procolobus
and langur genera among colobines. Although insufficient data, homoplasy and incomplete lineage sorting might all have contributed to the discordance among gene trees, hybridization is favored as the main cause of the observed discordance. We propose that African colobines are paraphyletic, but might later have experienced female introgression from
Piliocolobus
/
Procolobus
into
Colobus
. In the late Miocene, colobines invaded Eurasia and diversified into several lineages. Among Asian colobines,
Semnopithecus
diverged first, indicating langur paraphyly. However, unidirectional gene flow from
Semnopithecus
into
Trachypithecus
via male introgression followed by nuclear swamping might have occurred until the earliest Pleistocene.
Conclusions
Overall, our study provides the most comprehensive view on colobine evolution to date and emphasizes that analyses of various molecular markers, such as mobile elements and sequence data from multiple loci, are crucial to better understand evolutionary relationships and to trace hybridization events. Our results also suggest that sex-specific dispersal patterns, promoted by a respective social organization of the species involved, can result in different hybridization scenarios.
Journal Article
A new identification of the monkeys depicted in a Bronze Age wall painting from Akrotiri, Thera
Bronze Age Aegean (ca. 3500–1100 B.C.) wall paintings from the islands of Crete and Thera depict monkeys in a variety of roles such as running wild in nature, possibly following (trained) commands, and participating in sacred activities. These images, while stylistically Aegean, are traditionally considered closely related to—and descendant from—Egyptian, Near Eastern, and Mesopotamian monkey imagery. While monkey depictions in the latter regions may provide species-specific characteristics, Aegean wall paintings typically lack this level of detail. In an attempt to better understand the relationships between the monkeys depicted in Aegean wall paintings and the species that were encountered by the Aegean, Mesopotamian, and Egyptian peoples, a collaborative team of primatologists, a taxonomic illustrator, and an art historian/archaeologist identified species-indicative visual characteristics. This collaborative approach led us to identify a new region that serves as a source for monkey iconography: the Indus River Valley. With an emphasis on the primatological aspect and the growing corpus of possible Indus goods and possible species found in the Aegean, a broader iconographic and socioreligious sphere of interaction emerges. In this expanded system, Mesopotamia functions as an intermediary that enables the movement of goods, raw materials, people, and iconography between the east and west. Mesopotamia may have even afforded an opportunity for Aegean peoples to encounter the creatures themselves, first-hand. Of primary importance to the methodology employed for this project is the cooperation of scholars from disparate disciplines—the stitching together of various projects and experiences in attempt to answer both new and previously unanswerable questions. This type of interdisciplinary approach can be applied to other species, sites, paintings, and objects to hone our understanding of period, place, animal, movement, and trade.
Journal Article
The Curious Douglas-Fir (Pseudotsuga Menziesii) Trees in Schulman Grove, Mesa Verde National Park, Southwestern Colorado, USA
In 1954, archaeologists James Allen Lancaster and Don Watson and dendrochronologist Edmund Schulman asserted that a small grove of Douglas-fir (Pseudotsuga menziesii [Mirbel] Franco var. glauca [Beissener] Franco) trees in Navajo Canyon on the west side of Chapin Mesa in Mesa Verde National Park contained evidence of stone-axe-cut tree limbs. In 1965, archaeologists Robert Nichols and David Smith published an article entitled “Evidence of Prehistoric Cultivation of Douglas-Fir Trees at Mesa Verde,” in which they supported the Lancaster/Watson/Schulman assertion with tree-ring dates from suspected stone-axe-cut limbs. If correct, Nichols and Smith (1965) document the only trees in the entire U.S. Southwest that contain ancient stone-axe-cut stubs and evidence of precolumbian forest management. Rather than accept their interpretations at face value, we attempt to replicate their dates through the (re)analysis of archived and recently collected tree-ring samples, and through a controlled analysis and comparison of archived and published records. We could not confirm their results, and we have no option but to reject their claim that Schulman Grove contains evidence of precolumbian tree manipulation by Ancestral Puebloan inhabitants of Mesa Verde.
Journal Article
Multi-Center Randomized Phase II Study Comparing Cediranib plus Gefitinib with Cediranib plus Placebo in Subjects with Recurrent/Progressive Glioblastoma
Cediranib, an oral pan-vascular endothelial growth factor (VEGF) receptor tyrosine kinase inhibitor, failed to show benefit over lomustine in relapsed glioblastoma. One resistance mechanism for cediranib is up-regulation of epidermal growth factor receptor (EGFR). This study aimed to determine if dual therapy with cediranib and the oral EGFR inhibitor gefitinib improved outcome in recurrent glioblastoma.
This was a multi-center randomized, two-armed, double-blinded phase II study comparing cediranib plus gefitinib versus cediranib plus placebo in subjects with first relapse/first progression of glioblastoma following surgery and chemoradiotherapy. The primary outcome measure was progression free survival (PFS). Secondary outcome measures included overall survival (OS) and radiologic response rate. Recruitment was terminated early following suspension of the cediranib program. 38 subjects (112 planned) were enrolled with 19 subjects in each treatment arm. Median PFS with cediranib plus gefitinib was 3.6 months compared to 2.8 months for cediranib plus placebo (HR; 0.72, 90% CI; 0.41 to 1.26). Median OS was 7.2 months with cediranib plus gefitinib and 5.5 months with cediranib plus placebo (HR; 0.68, 90% CI; 0.39 to 1.19). Eight subjects (42%) had a partial response in the cediranib plus gefitinib arm versus five patients (26%) in the cediranib plus placebo arm.
Cediranib and gefitinib in combination is tolerated in patients with glioblastoma. Incomplete recruitment led to the study being underpowered. However, a trend towards improved survival and response rates with the addition of gefitinib to cediranib was observed. Further studies of the combination incorporating EGFR and VEGF inhibition are warranted.
ClinicalTrials.gov NCT01310855.
Journal Article