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This study aims to enhance the understanding of individual-level factors that influence rural women's intentions to engage in sustainable entrepreneurship in India. This study explores the direct impact of perceived capability, social perception, and individual competencies on women's sustainable entrepreneurial intention (SEI). In addition, this study investigated how these variables indirectly affect perceived opportunities. A quantitative methodology was used, with randomly distributed questionnaires among rural women in India. A total of 1250 responses were collected and analyzed using structural equation modeling (SEM) with partial least squares (PLS). The results revealed that perceived capability (β = 0.103), individual competencies (β = 0.052), and social perception (β = 0.226) significantly and positively influenced the SEI. Furthermore, this study indicates that perceived opportunity serves as a mediator in the relationships between perceived capability, social perception, individual competencies, and SEI of women. The proposed model explained 50.9% of the variance in SEI. This study contributes to the existing literature by empirically analyzing the connection between the individual characteristics of women and their intentions to pursue sustainable entrepreneurship, focusing specifically on rural women in India.

The main impetus of the research is to inquire into the fintech adoption behaviour of India's GenY population. The focus of this research paper is to enlarge the scope of the planned behaviour theory by including other exogenous variables, information quality (IQ), and readiness to pay for privileges. Responses from the 349 selected higher education students based on judgmental sampling were collected from various institutes of repute in India. The suggested framework was evaluated using the Smart PLS 4 software bootstrapping method. It was found that multiple hypotheses framed in the study exert notable impact besides the belief that there is a direct linkage between observed behavioural control (OBC) and actual intention (AI). The paper confirms the application of the theory of planned behaviour for the effective implementation of fintech in India. It was observed that information quality is one of the crucial elements which influences the fintech adoption behaviour. The research enriches past studies by expanding the blueprint of a theory of planned behaviour by identifying the information quality factor as the influencing intent and behaviour. The reliability and validity of the suggested framework were analyzed after keeping in mind the impact of a business environment's constantly changing dynamic forces. The study identified the primary constructs affecting the fintech adoption behaviour with a particular focus on the GEN Y population of India. It will also help the financial technocrats to optimally utilize the immense underlying capabilities of the fintech users and strategically launch more user-friendly products and services.

Rationale The relationship between subjective drug experience and antidepressant outcomes for ketamine derivatives is poorly understood but of high clinical relevance. Esketamine is the patented (S)-enantiomer of ketamine and has regulatory approval for psychiatric applications. Objectives We examined the relationship between acute dissociation, as measured by the Clinician-Administered Dissociative States Scale (CADSS), and antidepressant efficacy, as measured by the Montgomery-Åsberg Depression Rating Scale (MADRS), for esketamine across the 4-week induction phase of treatment. Methods This post hoc analysis combined data ( N  = 576) from the TRANSFORM-1 and TRANSFORM-2 clinical trials of esketamine for treatment-resistant depression. Linear mixed models were performed using total MADRS score as the outcome variable with the following independent variables: baseline MADRS score, treatment condition × time interaction, and CADSS × time interaction. To assess whether initial dissociation predicted rapid antidepressant benefit with esketamine, a separately planned regression was performed with day 2 MADRS as the outcome variable with the following dependent variables: baseline MADRS, treatment condition, and day 1 CADSS. Results The linear mixed model did not show any effect of a CADSS × time interaction ( p  = 0.7). Looking solely at the effect of day 1 CADSS on day 2 MADRS revealed that each additional CADSS point was associated with a − .04 [95% CI − .08, − .002] ( p  = .04) decrease in MADRS score. Conclusions We found no evidence of a clinically significant positive or negative association between dissociation and antidepressant effect for esketamine. Our findings suggest that subsequent inquiry in this area will benefit from improved characterization of drug experiences relevant to therapeutic outcomes.

ObjectiveHuman intestinal epithelial organoids (IEOs) are increasingly being recognised as a highly promising translational research tool. However, our understanding of their epigenetic molecular characteristics and behaviour in culture remains limited.DesignWe performed genome-wide DNA methylation and transcriptomic profiling of human IEOs derived from paediatric/adult and fetal small and large bowel as well as matching purified human gut epithelium. Furthermore, organoids were subjected to in vitro differentiation and genome editing using CRISPR/Cas9 technology.ResultsWe discovered stable epigenetic signatures which define regional differences in gut epithelial function, including induction of segment-specific genes during cellular differentiation. Established DNA methylation profiles were independent of cellular environment since organoids retained their regional DNA methylation over prolonged culture periods. In contrast to paediatric and adult organoids, fetal gut-derived organoids showed distinct dynamic changes of DNA methylation and gene expression in culture, indicative of an in vitro maturation. By applying CRISPR/Cas9 genome editing to fetal organoids, we demonstrate that this process is partly regulated by TET1, an enzyme involved in the DNA demethylation process. Lastly, generating IEOs from a child diagnosed with gastric heterotopia revealed persistent and distinct disease-associated DNA methylation differences, highlighting the use of organoids as disease-specific research models.ConclusionsOur study demonstrates striking similarities of epigenetic signatures in mucosa-derived IEOs with matching primary epithelium. Moreover, these results suggest that intestinal stem cell-intrinsic DNA methylation patterns establish and maintain regional gut specification and are involved in early epithelial development and disease.

The world is full of data which is increasing by leaps and bounds. In health care, big data is becoming common with increased electronic health data accumulation and/or accessibility to public data previously held under lock and key. At the same time, health data visualization applications have become popular over recent years. Against this background, a review was done to summarize the application of data visualization in public health & the challenges faced. Peer-reviewed original research articles and review articles searched in Google Scholar and Pubmed databases that were indexed in the last ten years period, using the keywords \"Big data\" or \"data visualization\" or \"Interactive visualization techniques.\" Other related information in books, blogs, and published documents were searched in Google search engine using the same keywords. Contents from the downloaded documents were presented and discussed under three headings viz. (a) the visualizations that are still current and how they have evolved further, (b) tools or methods that can be used by end-users to make their own modifications, (c) the platforms to disseminate them. Usage of different plots in public health is explained with suitable examples using the data from public health datasets. From the discussion it can be understood that when big data is visualized well, it can identify implementation gaps and disparities and accelerate implementation strategies to reach the population groups in most need for interventions. As health administrator may come from diverse specialties, robust training and career development for big data in public health is the need of the hour.

The Martian satellite Phobos is criss-crossed by linear grooves and crater chains whose origin is unexplained. Anomalous grooves are relatively young, and crosscut tidally predicted stress fields as Phobos spirals towards Mars. Here we report strong correspondence between these anomalous features and reaccretion patterns of sesquinary ejecta from impacts on Phobos. Escaping ejecta persistently imprint Phobos with linear, low-velocity crater chains (catenae) that match the geometry and morphology of prominent features that do not fit the tidal model. We prove that these cannot be older than Phobos’ current orbit inside Mars’ Roche limit. Distinctive reimpact patterns allow sesquinary craters to be traced back to their source, for the first time across any planetary body, creating a novel way to probe planetary surface characteristics. For example, we show that catena-producing craters likely formed in the gravity regime, providing constraints on the ejecta velocity field and knowledge of source crater material properties. The origin of the numerous linear grooves and craters that litter the Martian moon Phobos' surface remains enigmatic. Here, by modelling low-velocity escaping ejecta from impacts to Phobos, the authors show that several of these chains can be explained by reimpacting sesquinary ejecta shortly after ejection.

Entrepreneurship worldwide faces persistent challenges such as unequal access to resources, institutional disparities, and inconsistent policy frameworks. Higher education institutions (HEIs) face the critical challenge of fostering sustainable entrepreneurial intentions among students, particularly in developing economies where institutional and resource constraints limit entrepreneurship’s potential to contribute to the Sustainable Development Goals (SDGs). This study investigates the influence of universities, sustainable business values, and key antecedents of the Theory of Planned Behavior (TPB) on sustainable entrepreneurial intentions among students in Indian higher education institutions. Employing a cross-sectional design, data were gathered through a structured questionnaire administered to students enrolled in entrepreneurship education programs. The analysis was conducted using Partial Least Squares Structural Equation Modeling (PLS-SEM) to explore path relationships and test the hypothesized model. This study provides a theoretical contribution to the field of sustainable entrepreneurship education and sustainable entrepreneurial intention by offering valuable insights into the impact of behavioral factors on EI development among students in higher education institutions. These insights emphasize the need for integrating comprehensive, sustainability-focused content into entrepreneurship curricula to equip future entrepreneurs with the knowledge and skills essential for addressing environmental, social, and economic challenges. The practical implications of this research are twofold. First, it provides universities and policymakers with actionable insights to design and implement more effective and sustainability-centered entrepreneurship programs. Second, by fostering sustainable entrepreneurial mindsets, the study contributes to the promotion of responsible business practices and the stimulation of new venture creation, thereby supporting broader economic development goals in emerging economies.

MXenes are a new family of two-dimensional (2D) nanomaterials. They are inorganic compounds of metal carbides/nitrides/carbonitrides. Titanium carbide MXene (Ti3C2-MXene) was the first 2D nanomaterial reported in the MXene family in 2011. Owing to the good physical properties of Ti3C2-MXenes (e.g., conductivity, hydrophilicity, film-forming ability, elasticity) various applications in wearable sensors, energy harvesters, supercapacitors, electronic devices, etc., have been demonstrated. This paper presents the development of a piezoresistive Ti3C2-MXene sensor followed by experimental investigations of its dynamic response behavior when subjected to structural impacts. For the experimental investigations, an inclined ball impact test setup is constructed. Stainless steel balls of different masses and radii are used to apply repeatable impacts on a vertical cantilever plate. The Ti3C2-MXene sensor is attached to this cantilever plate along with a commercial piezoceramic sensor, and their responses for the structural impacts are compared. It is observed from the experiments that the average response times of the Ti3C2-MXene sensor and piezoceramic sensor are 1.28±0.24μs and 31.19±24.61μs, respectively. The fast response time of the Ti3C2-MXene sensor makes it a promising candidate for monitoring structural impacts.

This study investigated the influence of experiential learning (EL) on entrepreneurial intention (EI) of the students through the lens of perceived behavioural control (PBC). To present a comprehensive perspective, we have explored the direct influence of the antecedents associated with the theory of planned behavior (TPB). The data for were collected via a structured questionnaire from 1,250 final-year management science students. The study employed the partial least squares structural equation modelling method approach for data analysis. The results confirm positive relationships between EL and EI (β = 0.266). In addition, PBC mediates and enhances the relationship between EL and EI (β = 0.30). The result also showed that the TPB antecedents, namely entrepreneurial attitude, subjective norms, and PBC, significantly and positively influence students' EIs. The proposed model explains a 64% variance in EIs. Moreover, the influence of EL on EI gets stronger when PBC acts as a mediator. Therefore, it is necessary to concentrate on PBC and EL.The study has valuable insights and practical and theoretical implications forhigher education institutions, and policymakers on making more informed resource allocations and fostering an environment conducive to entrepreneurship.

•Semistructured interviews of patients with cancer consuming medical cannabis were analyzed using applied thematic analysis.•Preparation type, administration route, and dosing of medical cannabis vary dramatically among patients with cancer.•This study suggests the need for cannabis therapeutics educational programs and standardization of dispensary products. Medical cannabis (MC) is used by 1 in 3 patients with cancer. Scientific work suggests a disconnect between patients’ cannabis therapeutics practices and oncologists’ clinical preferences. This qualitative study explores the preferences of patients with cancer as they relate to MC formulations, administration routes, and dosing. Semistructured interviews were conducted with patients with cancer consuming MC in 8 states and examined using thematic analysis. Among study participants (N = 24), the mean age was 54 years, 67% were female, and 51% had metastatic disease. A powerful theme identified across interviews was of myriad MC dispensary product formulations, triggering astonishment and burden. Common strategies among participants included purchasing and sampling multiple store-bought formulations, modifying dispensary products, and altering intended routes of administration. Preferred dispensary products were not consistently available. Top-cited modes of administration included oral, followed by topical, sublingual, vaporization, combustion, and rectal suppository. Three-quarters of participants alternated between modes. Medical cannabis dosing imprecision represented another powerful theme due to the lack of dispensary quality assurance and accuracy in home measurements. This investigation suggests that MC preparations, dosing, and administration routes vary among patients with cancer, and that common consumption patterns (for instance, reliance on multiple routes of cannabis administration) are not rooted in science. Although these findings should be further interrogated, they suggest a need for lay-facing cannabis therapeutics education and standardization of dispensary products to strengthen cannabis-related care.