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"Neal"
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Everfound
In this conclusion to the trilogy, in the limbo that's Everlost, Mary, Nick, Allie and others face the decisions that will determine whether that place and the Earth itself will continue to exist, as well as where their own future lie.
Book
Functional characterization of the switchgrass (Panicum virgatum) R2R3‐MYB transcription factor PvMYB4 for improvement of lignocellulosic feedstocks
• The major obstacle for bioenergy production from switchgrass biomass is the low saccharification efficiency caused by cell wall recalcitrance. Saccharification efficiency is negatively correlated with both lignin content and cell wall ester‐linked p‐coumarate: ferulate (p‐CA : FA) ratio. In this study, we cloned and functionally characterized an R2R3‐MYB transcription factor from switchgrass and evaluated its potential for developing lignocellulosic feedstocks. • The switchgrass PvMYB4 cDNAs were cloned and expressed in Escherichia coli, yeast, tobacco and switchgrass for functional characterization. Analyses included determination of phylogenetic relations, in situ hybridization, electrophoretic mobility shift assays to determine binding sites in target promoters, and protoplast transactivation assays to demonstrate domains active on target promoters. • PvMYB4 binds to the AC‐I, AC‐II and AC‐III elements of monolignol pathway genes and down‐regulates these genes in vivo. Ectopic overexpression of PvMYB4 in transgenic switchgrass resulted in reduced lignin content and ester‐linked p‐CA : FA ratio, reduced plant stature, increased tillering and an approx. threefold increase in sugar release efficiency from cell wall residues. • We describe an alternative strategy for reducing recalcitrance in switchgrass by manipulating the expression of a key transcription factor instead of a lignin biosynthetic gene. PvMYB4‐OX transgenic switchgrass lines can be used as potential germplasm for improvement of lignocellulosic feedstocks and provide a platform for further understanding gene regulatory networks underlying switchgrass cell wall recalcitrance.
Journal Article
Prevalence, age of decision, and interpersonal warmth judgements of childfree adults: Replication and extensions
Childfree individuals, who are also described as ‘childless by choice’ or ‘voluntarily childless’, have decided they do not want biological or adopted children. This is an important population to understand because its members have unique reproductive health and end-of-life needs, and they encounter challenges managing work-life balance and with stereotypes. Prior estimates of childfree adults’ prevalence in the United States, their age of decision, and interpersonal warmth judgements have varied widely over time and by study design. To clarify these characteristics of the contemporary childfree population, we conduct a pre-registered direct replication of a recent population-representative study. All estimates concerning childfree adults replicate, boosting confidence in earlier conclusions that childfree people are numerous and decide early in life, and that parents exhibit strong in-group favoritism while childfree adults do not.
Journal Article
Anathem
Raz, a mathematician, is among a cohort of secluded scientists and philosophers who are called upon to save the world from impending catastrophe.
Book
Prevalence and characteristics of childfree adults in Michigan (USA)
Childfree individuals choose not to have children, which makes them a distinctive group from parents who have had children, not-yet-parents who plan to have children, and childless indivduals who would have liked to have children. Most research on parental status and psychosocial characteristics has not effectively distinguished childfree individuals from other non-parents or has relied on non-representative samples. In this study, we use a representative sample of 981 Michigan adults to estimate the prevalence of childfree individuals, to examine how childfree individuals differ from parents and other types of non-parents in life satisfaction, political ideology, and personality, and to examine whether childfree individuals are viewed as an outgroup. We find that over a quarter of Michigan adults identified as childfree. After controlling for demographic characteristics, we find no differences in life satisfaction and limited differences in personality traits between childfree individuals and parents, not-yet-parents, or childless individuals. However, childfree individuals were more liberal than parents, and those who have or want(ed) children felt substantially less warm toward childfree individuals than childfree individuals felt toward each other. Given the prevalence of childfree individuals, the risks of their outgroup status, and their potential role in politics as a uniquely liberal group, it is important for demographic research to distinguish the childfree from others and to better understand these individuals.
Journal Article
The Shadow Club
When a junior high school boy and his friends decide to form a club of \"second bests\" and play anonymous tricks on each other's arch rivals, the harmless pranks escalate until they become life-threatening.
Book
Addressing Injustice in the Medieval Body Politic
Justice and injustice were subjects of ongoing debate in medieval Europe. Received classical and biblical models both influenced how these qualities of moral and political life were perceived, discussed and acted upon. Important among these influences was the anonymous seventh-century Irish text, On The Twelve Abuses of the Age, a biblically-inspired discussion of the moral duties particular to each sector of society. This volume probes its long influence, and its interaction with the revival of classical ideas. By bringing together scholars of political thought and practice, in lay and religious contexts spanning the seventh to fourteenth centuries, this volume crosses boundaries of periodisation, discipline and approach to reflect upon the medieval evolution of concepts of injustice and means of redress. Contributions address how ideas about justice and injustice were discussed among scholars and theologians, and how those ideas were translated into action through complaint and advice throughout the medieval period.
eBook
American Society of Regional Anesthesia and Pain Medicine Local Anesthetic Systemic Toxicity checklist: 2020 version
The American Society of Regional Anesthesia and Pain Medicine (ASRA) periodically updates its practice advisories and associated cognitive aids. The 2020 version of the ASRA Local Anesthetic Systemic Toxicity checklist was created in response to user feedback, simulation studies and advances in medical knowledge. This report presents the 2020 version and discusses the rationale for its update.
Journal Article