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"Neal, S"
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Your body in balance : the new science of food, hormones, and health
\"Barnard provides readers with a way to use food to protect against chronic and terminal health problems caused by the excess hormones that are lurking in our diets\"-- Provided by publisher.
Book
Aplastic Anemia
Once a uniformly fatal disease, aplastic anemia is now curable with allogeneic transplantation in 80% of children and 40% of adults, and immunosuppression with or without eltrombopag can induce long remissions in most adults.
Journal Article
Absolute Green Lantern/Green Arrow
\"This stunning Absolute Edition of Green Lantern/Green Arrow collect the early 1970s, featuring classic team-ups written by Dennis O'Neil with art by Neal Adams! In these stories, Green Lantern Hal Jordan continued his usual cosmic-spanning adventures, as he used his amazing Power Ring to police Sector 2814 against universe-threatening menaces. Meanwhile, on Earth, Oliver Queen, the archer known as Green Arrow, was confronting menaces of a different kind: racism, poverty, drugs, and other social ills! This Absolute Edition will include additional script and character development pages as well as character sketches\"-- Provided by publisher.
Book
Somatic Mutations in “Benign” Disease
DNA mutations occur in nearly every tissue throughout the human life span and accumulate at various rates in different tissues according to intrinsic and extrinsic factors. If a mutated clone acquires features that confer a competitive advantage, clonal dominance can emerge. Such alterations can have functional consequences and cause disease.
Journal Article
Violent ends : a novel in seventeen points of view
Relates how one boy--who had friends, enjoyed reading, playing saxophone in the band, and had never been in trouble before--became a monster capable of entering his high school with a loaded gun and firing on his classmates, as told from the viewpoints of several victims. Each perspective is written by a different writer of young adult fiction.
Book
Comparison of transcriptomes from two chemosensory organs in four decapod crustaceans reveals hundreds of candidate chemoreceptor proteins
Crustaceans express genes for at least three classes of putative chemosensory proteins. These are: Ionotropic Receptors (IRs), derived from the heterotetrameric ionotropic glutamate receptors (iGluRs); Transient Receptor Potential (TRP) channels, a diverse set of sensor-channels that include several families of chemoreceptor channels; and Gustatory Receptor Like receptors (GRLs), ionotropic receptors that are homologues of Gustatory Receptors (GRs) of insects and are expressed sparingly in most crustaceans so far studied. IRs are typically numerically the most dominant of these receptor proteins in crustaceans and include two classes: co-receptor IRs, which are necessary for making a functional receptor-channel; and tuning IRs, whose specific combination in the IR subunits in the heterotetramer confers chemical specificity. Previous work showed that the transcriptomes from two major chemosensory organs-the lateral flagellum of the antennule (LF) and the tips of the legs (dactyls)-of the Caribbean spiny lobster Panulirus argus express four co-receptor IRs and over 100 tuning IRs. In this paper, we examined and compared the transcriptomes from the LF and dactyls of P. argus and three other decapod crustaceans-the clawed lobster Homarus americanus, red swamp crayfish Procambarus clarkii, and the blue crab Callinectes sapidus. Each species has at least ca. 100 to 250 IRs, 1 to 4 GRLs, and ca. 15 TRP channels including those shown to be involved in chemoreception in other species. The IRs show different degrees of phylogenetic conservation: some are arthropod-conserved, others are pancrustacean-conserved, others appear to be crustacean-conserved, and some appear to be species-specific. Many IRs appear to be more highly expressed in the LF than dactyl. Our results show that decapod crustaceans express an abundance of genes for chemoreceptor proteins of different types, phylogenetic conservation, and expression patterns. An understanding of their functional roles awaits determining their expression patterns in individual chemosensory neurons and the central projections of those neurons.
Journal Article
Ulcerative colitis mucosal transcriptomes reveal mitochondriopathy and personalized mechanisms underlying disease severity and treatment response
Molecular mechanisms driving disease course and response to therapy in ulcerative colitis (UC) are not well understood. Here, we use RNAseq to define pre-treatment rectal gene expression, and fecal microbiota profiles, in 206 pediatric UC patients receiving standardised therapy. We validate our key findings in adult and paediatric UC cohorts of 408 participants. We observe a marked suppression of mitochondrial genes and function across cohorts in active UC, and that increasing disease severity is notable for enrichment of adenoma/adenocarcinoma and innate immune genes. A subset of severity genes improves prediction of corticosteroid-induced remission in the discovery cohort; this gene signature is also associated with response to anti-TNFα and anti-α
4
β
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integrin in adults. The severity and therapeutic response gene signatures were in turn associated with shifts in microbes previously implicated in mucosal homeostasis. Our data provide insights into UC pathogenesis, and may prioritise future therapies for nonresponders to current approaches.
The severity of ulcerative colitis, and response to treatment, is highly variable. Here, the authors examine rectal gene expression signatures and faecal microbiomes of children and adults with the disease and provide new insights in to pathogenesis.
Journal Article
Philosophical in Confronting Rejection: language confusion in the correspondence between editor and author
Publication of scientific and biomedical manuscripts in “high impact factor” (IF) journals is important in advancing careers, obtaining funding, and developing a field of research. Rejection by prestigious journals is not infrequent and usually painful, especially to young investigators. Reasons provided by an editor are often confusing. We assess the language of the rejection letter from a specific philosophical stance, originated by Ludwig Wittgenstein. Wittgenstein’s late writings on language as usage and as inherent to human activity have profoundly influenced many of the humanities but have been less frequently applied to the sciences. However, Wittgenstein’s ideas about language have relevance for understanding editorial correspondence and also, more broadly, for our thinking about scientific work and “science.”
Journal Article
Single-cell RNA sequencing coupled to TCR profiling of large granular lymphocyte leukemia T cells
T-cell large granular lymphocyte leukemia (T-LGLL) is a lymphoproliferative disease and bone marrow failure syndrome which responds to immunosuppressive therapies. We show single-cell TCR coupled with RNA sequencing of CD3
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T cells from 13 patients, sampled before and after alemtuzumab treatments. Effector memory T cells and loss of T cell receptor (TCR) repertoire diversity are prevalent in T-LGLL. Shared TCRA and TCRB clonotypes are absent. Deregulation of cell survival and apoptosis gene programs, and marked downregulation of apoptosis genes in CD8
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clones, are prominent features of T-LGLL cells. Apoptosis genes are upregulated after alemtuzumab treatment, especially in responders than non-responders; baseline expression levels of apoptosis genes are predictive of hematologic response. Alemtuzumab does not attenuate TCR clonality, and TCR diversity is further skewed after treatment. Inferences made from analysis of single cell data inform understanding of the pathophysiologic mechanisms of clonal expansion and persistence in T-LGLL.
T cell large granular lymphocyte leukemia (T-LGLL) and the cellular phenotype underlying response to therapy is not well understood. Here the authors use single cell sequencing to better understand changes in T cell clonal frequency and gene expression before and after therapy in T-LGLL.
Journal Article