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New whole‐rock major and trace element geochemistry from the Leka Ophiolite Complex in Norway is presented and compared to the geochemical evolution and proposed tectonomagmatic processes recorded in the Izu‐Bonin‐Mariana system. These data demonstrate that the Leka Ophiolite Complex formed as forearc lithosphere during subduction initiation. A new high‐precision zircon U‐Pb date on forearc basalt constrains the timing of subduction initiation in the “Leka sector” of the Iapetus Ocean to 491.36 ± 0.17 Ma. The tectonomagmatic record of the Leka Ophiolite Complex captures only the earliest stages of subduction initiation and is thereby distinct from some other Appalachian–Caledonian ophiolites of similar age. The diversity of Appalachian–Caledonian ophiolite records may represent differing preservation and exposure of a variable forearc lithosphere. Plain Language Summary The Leka Ophiolite Complex (LOC) represents a preserved fragment of oceanic crust that formed during subduction in the Iapetus Ocean. Geochemical information recorded in the LOC rocks shows that it formed during the initial phase of subduction. The age of subduction initiation in the Iapetus Ocean is estimated at 491.36 million years ago based on isotopic dating of minerals within the LOC rocks. Other fragments of preserved oceanic crust with similar ages are found in the Appalachian–Caledonian mountains; however, their geochemical information suggests that they may have formed during different stages of the subduction zone development. We consider the variations in the oceanic crustal record to reflect selective preservation of different parts of the variable oceanic crust formed during the development of a subduction zone in the Iapetus Ocean. Key Points The Leka Ophiolite Complex (LOC) preserves a record of geochemical variation from forearc basaltic to boninitic magmatism, reflecting formation during initiation and early evolution of a subduction zone A 491.36 ± 0.17 Ma U–Pb zircon date for an LOC forearc basalt is considered to date subduction initiation in the “Leka sector” of the Iapetus Ocean Differences between the LOC pseudostratigraphy and the model Izu‐Bonin‐Mariana forearc may result from selective preservation of the spatially variable forearc lithosphere in addition to the specific history of formation, obduction, deformation, and uplift/erosion records

Central aims of IODP Expedition 352 were to delineate and characterize the magmatic stratigraphy in the Bonin forearc to define key magmatic processes associated with subduction initiation and their potential links to ophiolites. Expedition 352 penetrated 1.2 km of magmatic basement at four sites and recovered three principal lithologies: tholeiitic forearc basalt (FAB), high-Mg andesite, and boninite, with subordinate andesite. Boninites are subdivided into basaltic, low-Si, and high-Si varieties. The purpose of this study is to determine conditions of crystal growth and differentiation for Expedition 352 lavas and compare and contrast these conditions with those recorded in lavas from mid-ocean ridges, forearcs, and ophiolites. Cr# (cationic Cr/Cr+Al) vs. TiO relations in spinel and clinopyroxene demonstrate a trend of source depletion with time for the Expedition 352 forearc basalt to boninite sequence that is similar to sequences in the Oman and other suprasubduction zone ophiolites. Clinopyroxene thermobarometry results indicate that FAB crystallized at temperatures (1142–1190 °C) within the range of MORB (1133–1240 °C). When taking into consideration liquid lines of descent of boninite, orthopyroxene barometry and olivine thermometry of Expedition 352 boninites demonstrate that they crystallized at temperatures marginally lower than those of FAB, between ~1119 and ~1202 °C and at relatively lower pressure (~0.2–0.4 vs. 0.5–4.6 kbar for FAB). Elevated temperatures of boninite orthopyroxene (~1214 °C for low-Si boninite and 1231–1264 °C for high-Si boninite) may suggest latent heat produced by the rapid crystallization of orthopyroxene. The lower pressure of crystallization of the boninite may be explained by their lower density and hence higher ascent rate, and shorter distance of travel from place of magma formation to site of crystallization, which allowed the more buoyant and faster ascending boninites to rise to shallower levels before crystallizing, thus preserving their high temperatures.

Mafic complexes in the central Sierra Nevada batholith record valuable geochemical information regarding the role mafic magmas play in arc magmatism and the generation of continental crust. In the intrusive suite of Yosemite Valley, major and trace element compositions of the hornblende-bearing gabbroic rocks from the Rockslides mafic complex and of the mafic dikes in the North America Wall are compositionally similar to high-alumina basalt. Of these rocks, two samples have higher Ni and Cr abundances as well as higher ε Nd values than previously recognized for the intrusive suite. Plagioclase crystals in rocks from the North America Wall and the Rockslides have prominent calcic cores and sharply defined sodic rims, a texture commonly associated with mixing of mafic and felsic magmas. In situ analyses of 87 Sr/ 86 Sr in plagioclase show no significant isotopic difference from the cores to the rims of these grains. We propose that the high 87 Sr/ 86 Sr (~0.7067) and low ε Nd (~−3.4) of bulk rocks, the homogeneity of 87 Sr/ 86 Sr in plagioclase, and the high δ 18 O values of bulk rocks (6.6–7.3 ‰) and zircon (Lackey et al. in J Petrol 49:1397–1426, 2008 ) demonstrate that continental crust was assimilated into the sublithospheric mantle-derived basaltic precursors of the mafic rocks in Yosemite Valley. Contamination (20–40 %) likely occurred in the lower crust as the magma differentiated to high-alumina basalt prior to plagioclase (and zircon) crystallization. As a consequence, the isotopic signatures recorded by whole rocks, plagioclase, and zircon do not represent the composition of the underlying lithospheric mantle. We conclude that the mafic and associated felsic members of the intrusive suite of Yosemite Valley represent 60–80 % new additions to the crust and include significant quantities of recycled ancient crust.

This dissertation presents new geochemical data investigating the origin of the chemically dissimilar Kenya and Afar mantle plumes and the contributions of these plumes to volcanism beneath Ethiopia. This study focuses primarily on mafic lavas from three localities on the poorly characterized eastern Ethiopian plateau but also includes lavas from the northwest Ethiopian plateau as well as Re-Os isotopic data from various key locations throughout the East Africa Rift System. The location of the samples sites provides a framework for a spatial and temporal assessment of the influence the Afar and Kenya plumes have on volcanism. We are also able to evaluate the role of the lithospheric mantle including its contribution to melt production and its influence on upwelling mantle plume material. Expansion of the data set to include northwest Ethiopian plateau lavas and key volcanic sites throughout the region allow us to consider the origin of HIMU mantle component observed in Kenya plume lavas but absent from Afar plume products. Geochemical data demonstrate the sources contributing to volcanism on the eastern Ethiopian plateau vary over space and time. Northernmost Oligocene-Miocene lavas from Asbe Tefari are chemically similar to well characterized high-TiO 2 Afar plume flood basalts from northwest Ethiopia. These lavas are chemically evolved and record contributions from the continental crust. Debre Sahil and Bale Mountains lavas are respectively located 85 km and 230 km to the southwest. Unlike Asbe Tefari basalts, Miocene Debre Sahil and Bale Mountains lavas are chemically similar to Kenya plume lavas produced in Turkana (northern Kenya). Pliocene-Recent Bale Mountains lavas do not resemble their Miocene predecessors but are compositionally similar to Quaternary lavas found within the Main Ethiopian Rift indicating a change in source beneath the Bale Mountains over time. Miocene-Recent alkaline lavas from Debre Sahil and Bale Mountains were derived near the base of the subcontinental lithospheric mantle and record its variable influence. In contrast, transitional Miocene lavas were generated with the asthenosphere and did not experience lithospheric contamination, thus recording Kenya plume compositions. The Kenya and Afar mantle plumes are consistent isotopically with low 3He/4He HIMU and high 3He/4He “C” mantle components, respectively. Re-Os isotopic data demonstrate the Kenya plume is the product of mixing recycling ~ 2 Ga oceanic crust with typical enriched mantle plume material, producing 187Os/188 Os = 0.1450-0.1483 similar to other global HIMU OIB. The Afar plume has typical enriched plume values (187Os/188Os = 0.1239-0.1311). Sr-Nd-Pb isotopic data from eastern plateau lava are consistent with major and trace element geochemical data. Asbe Tefari record “C” like Afar contributions. Miocene Debre Sahil and Bale Mountain lavas have a HIMU-flavor, though transitional Bale Mountains lavas display a more dilute signature due to chemical heterogeneities within the Kenya plume or mixing with Afar plume material prior to eruption. Pliocene-Recent Bale Mountains lavas record Afar contributions consistent with Main Ethiopian Rift lavas. Hf isotopic data demonstrate HIMU-Kenya plume lavas likely incorporated a recycled oceanic crust while lavas with Afar plume signature have signatures consistent with peridotite melting. Transitional Bale Mountains lavas and high-TiO2 lavas from northwest Ethiopia have high-Ni olivine, indicative of pyroxenite melting. In contrast, alkaline HIMU-flavored lavas Debre Sahil, Bale Mountains, and Turkana have low-Ni olivine. We suggest that recycled oceanic crust is present in both Afar and Kenya plumes. The thick lithosphere beneath the Ethiopian plateau promotes the reaction between eclogite melt and peridotite solid to form pyroxenite while thin lithosphere beneath Turkana allows peridotite to melt and mix with eclogite melt instead of forming pyroxenite. Pyroxenite melts will record isotopic signatures similar to the parent peridotite while eclogite-peridotite melt mixes will have a stronger recycled (HIMU) component.

The East African Rift System was initiated by the impingement of the Afar mantle plume on the base of the non-cratonic continental lithosphere (assembled during the Pan-African Orogeny), producing over 300,000 kmof continental flood basalts approx.30 Ma ago. The contribution of the subcontinental lithospheric mantle (SCLM) to this voluminous period of volcanism is implied based on basaltic geochemical and isotopic data. However, the role of percolating melts on the SCLM composition is less clear. Metasomatism is capable of hybridizing or overprinting the geochemical signature of the SCLM. In addition, models suggest that adding fluids to lithospheric mantle affects its stability. We investigated the nature of the SCLM using Fourier transform infrared spectrometry (FTIR) to measure water content in mantle xenoliths entrained in young (1 Ma) basaltic lavas from the Ethiopian volcanic province. The mantle xenoliths consist dominantly of spinel lherzolites and are composed of nominally anhydrous minerals, which can contain trace water as H in mineral defects. Eleven mantle xenoliths come from the Injibara-Gojam region and two from the Mega-Sidamo region. Water abundances of olivines in six samples are 1-5ppm H2O while the rest are below the limit of detection (<0.5 ppm H2O); orthopyroxene and clinopyroxene contain 80-238 and 111-340 ppm wt H2O, respectively. Two xenoliths have higher water contents - a websterite (470 ppm) and dunite (229 ppm), consistent with involvement of ascending melts. The low water content of the upper SCLM beneath Ethiopia is as dry as the oceanic mantle except for small domains represented by percolating melts. Consequently, rifting of the East African lithosphere may not have been facilitated by a hydrated upper mantle.

Climate change is impacting the function and distribution of habitats used by marine, coastal, and diadromous species. These impacts often exacerbate the anthropogenic stressors that habitats face, particularly in the coastal environment. We conducted a climate vulnerability assessment of 52 marine, estuarine, and riverine habitats in the Northeast U.S. to develop an ecosystem-scale understanding of the impact of climate change on these habitats. The trait-based assessment considers the overall vulnerability of a habitat to climate change to be a function of two main components, sensitivity and exposure, and relies on a process of expert elicitation. The climate vulnerability ranks ranged from low to very high, with living habitats identified as the most vulnerable. Over half of the habitats examined in this study are expected to be impacted negatively by climate change, while four habitats are expected to have positive effects. Coastal habitats were also identified as highly vulnerable, in part due to the influence of non-climate anthropogenic stressors. The results of this assessment provide regional managers and scientists with a tool to inform habitat conservation, restoration, and research priorities, fisheries and protected species management, and coastal and ocean planning.

Pandemic politics highlight how predictions need to be transparent and humble to invite insight, not blame. Pandemic politics highlight how predictions need to be transparent and humble to invite insight, not blame.

Background The availability of thousands of complete rice genome sequences from diverse varieties and accessions has laid the foundation for in-depth exploration of the rice genome. One drawback to these collections is that most of these rice varieties have long life cycles, and/or low transformation efficiencies, which limits their usefulness as model organisms for functional genomics studies. In contrast, the rice variety Kitaake has a rapid life cycle (9 weeks seed to seed) and is easy to transform and propagate. For these reasons, Kitaake has emerged as a model for studies of diverse monocotyledonous species. Results Here, we report the de novo genome sequencing and analysis of Oryza sativa ssp. japonica variety KitaakeX, a Kitaake plant carrying the rice XA21 immune receptor. Our KitaakeX sequence assembly contains 377.6 Mb, consisting of 33 scaffolds (476 contigs) with a contig N50 of 1.4 Mb. Complementing the assembly are detailed gene annotations of 35,594 protein coding genes. We identified 331,335 genomic variations between KitaakeX and Nipponbare (ssp. japonica ), and 2,785,991 variations between KitaakeX and Zhenshan97 (ssp. indica ). We also compared Kitaake resequencing reads to the KitaakeX assembly and identified 219 small variations. The high-quality genome of the model rice plant KitaakeX will accelerate rice functional genomics. Conclusions The high quality, de novo assembly of the KitaakeX genome will serve as a useful reference genome for rice and will accelerate functional genomics studies of rice and other species.

The UK Biobank is a prospective study of 502,543 individuals, combining extensive phenotypic and genotypic data with streamlined access for researchers around the world 1 . Here we describe the release of exome-sequence data for the first 49,960 study participants, revealing approximately 4 million coding variants (of which around 98.6% have a frequency of less than 1%). The data include 198,269 autosomal predicted loss-of-function (LOF) variants, a more than 14-fold increase compared to the imputed sequence. Nearly all genes (more than 97%) had at least one carrier with a LOF variant, and most genes (more than 69%) had at least ten carriers with a LOF variant. We illustrate the power of characterizing LOF variants in this population through association analyses across 1,730 phenotypes. In addition to replicating established associations, we found novel LOF variants with large effects on disease traits, including PIEZO1 on varicose veins, COL6A1 on corneal resistance, MEPE on bone density, and IQGAP2 and GMPR on blood cell traits. We further demonstrate the value of exome sequencing by surveying the prevalence of pathogenic variants of clinical importance, and show that 2% of this population has a medically actionable variant. Furthermore, we characterize the penetrance of cancer in carriers of pathogenic BRCA1 and BRCA2 variants. Exome sequences from the first 49,960 participants highlight the promise of genome sequencing in large population-based studies and are now accessible to the scientific community. Exome sequences from the first 49,960 participants in the UK Biobank highlight the promise of genome sequencing in large population-based studies and are now accessible to the scientific community.

Winkler et al . show that the glucose transporter GLUT1 in brain endothelium is necessary for the maintenance of proper brain capillary networks and blood-brain barrier integrity. The study also shows that loss of GLUT1 in a mouse model of Alzheimer's disease accelerates BBB breakdown, perfusion and metabolic stress resulting in behavioral deficits, elevated amyloid beta levels and neurodegeneration. The glucose transporter GLUT1 at the blood-brain barrier (BBB) mediates glucose transport into the brain. Alzheimer's disease is characterized by early reductions in glucose transport associated with diminished GLUT1 expression at the BBB. Whether GLUT1 reduction influences disease pathogenesis remains, however, elusive. Here we show that GLUT1 deficiency in mice overexpressing amyloid β-peptide (Aβ) precursor protein leads to early cerebral microvascular degeneration, blood flow reductions and dysregulation and BBB breakdown, and to accelerated amyloid β-peptide (Aβ) pathology, reduced Aβ clearance, diminished neuronal activity, behavioral deficits, and progressive neuronal loss and neurodegeneration that develop after initial cerebrovascular degenerative changes. We also show that GLUT1 deficiency in endothelium, but not in astrocytes, initiates the vascular phenotype as shown by BBB breakdown. Thus, reduced BBB GLUT1 expression worsens Alzheimer's disease cerebrovascular degeneration, neuropathology and cognitive function, suggesting that GLUT1 may represent a therapeutic target for Alzheimer's disease vasculo-neuronal dysfunction and degeneration.