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The healthcare landscape in South Africa is challenging with a complex patient population and a stressed healthcare system. Negative pressure therapy‐based systems such as negative pressure wound therapy with instillation and dwell (NPWTi‐d) and closed incision negative pressure therapy (ciNPT) can help manage wounds or incisions. However, guidelines for South Africa‐specific use are limited. An in‐person meeting was held with 10 experts to develop South Africa‐specific therapy use recommendations for NPWTi‐d and ciNPT. Panel members recommended NPWTi‐d use for wounds in need of cleansing. Normal saline and a 10‐min dwell time were recommended with the caveat that the instillation solutions and dwell times can be changed based on the wound bed condition and the features of the instillation solution. A negative pressure cycle of 2–3 h and a negative pressure of −125 mmHg were also recommended for NPWTi‐d. In patients, incisions, and surgical procedures at high risk of developing surgical site complications, ciNPT use was recommended. These general recommendations serve as a framework for NPWTi‐d and/or ciNPT use in South Africa and should be updated as more region‐specific evidence becomes available.