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"Nicholas, James C"
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Market Based Approaches to Environmental Preservation: To Environmental Mitigation Fees and Beyond
Impact fees are widely accepted and utilized across the United States as a technique to generate revenue for capital infrastructure improvements necessitated by new development. This article looks at the origination of impact fees, their legal framework, the extension of the concept towards environmental protection, and an alternative economic approach in environmental protection, \"market based regulation.\" Based upon techniques utilized primarily in the arenas of wetlands and air quality regulation, a concept of utilizing economic incentives for broader environmental protection is explored. Considerations of the legal framework evolved through impacts fees are then applied to possible implementation aspects of the concept.
Journal Article
On the Progression of Impact Fees
This article examines various methods of assessing impact fees to cover infrastructure costs in terms of their socioeconomic consequences, and proposes an approach that appears to be more equitable than currently used techniques.
Journal Article
An epigenomic approach to therapy for tamoxifen-resistant breast cancer
Tamoxifen has been a frontline treatment for estrogen receptor alpha （ERα）-positive breast tumors in premenopausal women. However, resistance to tamoxifen occurs in many patients. ER still plays a critical role in the growth of breast cancer cells with acquired tamoxifen resistance, suggesting that ERa remains a valid target for treatment of tamoxifen-resistant （Tam-R） breast cancer. In an effort to identify novel regulators of ERa signaling, through a small-scale siRNA screen against histone methyl modifiers, we found WHSC1, a histone H3K36 methyltransferase, as a positive regulator of ERa signaling in breast cancer cells. We demonstrated that WHSC1 is recruited to the ERa gene by the BET protein BRD3/4, and facilitates ERa gene expression. The small-molecule BET protein inhibitor JQ1 potently suppressed the classic ERa signaling pathway and the growth of Tam-R breast cancer cells in culture. Using a Tam-R breast cancer xenograft mouse model, we demonstrated in vivo anti-breast cancer activity by JQ1 and a strong long-lasting effect of combination therapy with JQ1 and the ER degrader fnlvestrant. Taken together, we provide evidence that the epigenomic proteins BRD3/4 and WHSC1 are essential regulators of estrogen receptor signaling and are novel therapeutic targets for treatment of Tam-R breast cancer.
Journal Article
Loving Growth Management in the Time of Recession1
In the past, projected revenues and infrastructure needs returned to anticipated levels in a relatively short time and often rose even above those used as the basis for the capital improvement program and its anticipated revenue. [...] growth management programs must play a larger role in ameliorating the \"normal\" business cycles.
Journal Article
TDR handbook
How TDRs work -- Comparing TDRs to other preservation solutions -- The economics of TDRs -- Purchase of development rights -- Density transfer charges -- TDRs and the planning connection -- The seven steps of TDR planning -- Designing sending areas -- Designing receiving areas -- Legal issues -- A review of state statutes -- TDR program administration -- Programs with purpose -- Farmland preservation case studies -- Farmland and environmental preservation case studies -- Environmental preservation case studies -- Rural character preservation case studies -- Historic preservation case studies -- Urban design and revitalization case studies -- The promise and future of TDRs
Book
Workforce and Affordable Housing: Local Government Inclusionary Housing Programs and the Courts
The current surplus of housing should not disguise the fact that there is a
chronic national affordable housing supply crisis. Aside from building
public housing with decidedly mixed success, local governments have addressed
the problem by means of mandatory affordable housing set-asides
for new construction or the application of affordable housing fees to private
developments during the land use entitlement process. However, measures meant to address the dearth of affordable
housing have struggled in the courts, which have repeatedly pointed
to three flaws in these programs: a lack of local authority, a lack of nexus between
the proposed development and the need for affordable housing, and
affordable housing requirements disproportionate to the need created by the development project.
Journal Article