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Background Psychological stress and anxiety have seriously affected the ability of new clinicians to adapt and coordinate their clinical work. Traditional pre-job training is often not very good at assisting new recruits to regulate their emotional problems. Methods This study is a randomized controlled study. A total of 435 newly recruited clinicians participated in the study. 428 clinicians were randomized into a control group ( n  = 214) and an intervention group ( n  = 214). The control group conducted regular pre-job training. Doctors of the intervention group attend a themed course every two weeks on the basis of regular induction training. Their physiological status was evaluated by Perceived Stress Scale (PPS-10), Generalized Anxiety Scale (GAD-7) and Psychological Resilience Scale (CD-RISC-10) 3 months later. Participants in the intervention group received a training satisfaction questionnaire. Results After entering the clinic for 3 months, the PSS-10 and GAD-7 scores of the intervention group were significantly lower than that of the control group. Consistently, the CD-RISC-10 score of new clinicians who received proof-of-concept pre-job training was significantly higher than that of new doctors in the control group. Conclusion New doctors received the proof-of-concept group experienced alleviation in stress and anxiety.

The purpose of this study is to investigate the relationship between physical activity and exercise self-efficacy among college students and to examine the mediating effects of loneliness and body image. Through an analysis of parallel mediating effects, the intrinsic mechanisms underlying these variables are revealed and provide theoretical support for promoting healthy behaviours among college students. The study, conducted in April 2025, employed a cross-sectional design to survey college students across northeast, North, central, East, and South China. A total of 1102 valid questionnaires were collected. The level of physical activity was assessed using the Physical Activity Rating Scale (PARS-3). Exercise self-efficacy was measured using the Exercise Self-Efficacy Scale. Body image was assessed using the Physical Self-Esteem Scale (PSPP), and loneliness was calculated using the UCLA Loneliness Inventory (3rd edition). The data were analysed using SPSS 27 software for descriptive statistics, correlation analyses, and mediation effect analyses. A significant direct positive correlation was found between physical activity and exercise self-efficacy (β = 0.2313, p  < 0.001). Furthermore, loneliness and body image played important mediating roles in the relationship between physical activity and exercise self-efficacy. Specifically, physical activity indirectly improved exercise self-efficacy by reducing loneliness (β=-0.124, p  < 0.001) and enhancing body image (β = 0.383, p  < 0.001). The mediating effect accounted for 32.1% of the total impact, and the mediating effect of body image (28.5%) was significantly more potent than that of loneliness (3.5%). This study reveals the mechanism by which physical activity indirectly increases college students’ sense of exercise self-efficacy by reducing loneliness and improving body image. This finding shows the importance of focusing on individual psychological states when promoting physical activity. Interventions should promote both positive body image and a favourable social environment to improve college students’ exercise self-efficacy and overall psychological well-being.

Since the release of the complete human genome, the priority of human genomic study has now been shifting towards closing gaps in ethnic diversity. Here, we present a fully phased and well-annotated diploid human genome from a Han Chinese male individual (CN1), in which the assemblies of both haploids achieve the telomere-to-telomere (T2T) level. Comparison of this diploid genome with the CHM13 haploid T2T genome revealed significant variations in the centromere. Outside the centromere, we discovered 11,413 structural variations, including numerous novel ones. We also detected thousands of CN1 alleles that have accumulated high substitution rates and a few that have been under positive selection in the East Asian population. Further, we found that CN1 outperforms CHM13 as a reference genome in mapping and variant calling for the East Asian population owing to the distinct structural variants of the two references. Comparison of SNP calling for a large cohort of 8869 Chinese genomes using CN1 and CHM13 as reference respectively showed that the reference bias profoundly impacts rare SNP calling, with nearly 2 million rare SNPs miss-called with different reference genomes. Finally, applying the CN1 as a reference, we discovered 5.80 Mb and 4.21 Mb putative introgression sequences from Neanderthal and Denisovan, respectively, including many East Asian specific ones undetected using CHM13 as the reference. Our analyses reveal the advances of using CN1 as a reference for population genomic studies and paleo-genomic studies. This complete genome will serve as an alternative reference for future genomic studies on the East Asian population.

SH3 and Multiple Ankyrin Repeat Domains 3 ( SHANK3 )-caused autism spectrum disorder (ASD) may present a unique opportunity to clarify the heterogeneous neuropathological mechanisms of ASD. However, the specificity and commonality of disrupted large-scale brain organization in SHANK3- deficient children remain largely unknown. The present study combined genetic tests, neurobehavioral evaluations, and magnetic resonance imaging, aiming to explore the disruptions of both local and networked cortical structural organization in ASD children with and without SHANK3 deficiency. Multiple surface morphological parameters such as cortical thickness (CT) and sulcus depth were estimated, and the graph theory was adopted to characterize the topological properties of structural covariance networks (SCNs). Finally, a correlation analysis between the alterations in brain morphological features and the neurobehavioral evaluations was performed. Compared with typically developed children, increased CT and reduced nodal degree were found in both ASD children with and without SHANK3 defects mainly in the lateral temporal cortex, prefrontal cortex (PFC), temporo-parietal junction (TPJ), superior temporal gyrus (STG), and limbic/paralimbic regions. Besides commonality, our findings showed some distinct abnormalities in ASD children with SHANK3 defects compared to those without. Locally, more changes in the STG and orbitofrontal cortex were exhibited in ASD children with SHANK3 defects, while more changes in the TPJ and inferior parietal lobe (IPL) in those without SHANK3 defects were observed. For the SCNs, a trend toward regular network topology was observed in ASD children with SHANK3 defects, but not in those without. In addition, ASD children with SHANK3 defects showed more alterations of nodal degrees in the anterior and posterior cingulate cortices and right insular, while there were more disruptions in the sensorimotor areas and the left insular and dorsomedial PFC in ASD without SHANK3 defects. Our findings indicate dissociable disruptions of local and networked brain morphological features in ASD children with and without SHANK3 deficiency. Moreover, this monogenic study may provide a valuable path for parsing the heterogeneity of brain disturbances in ASD.