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The radioactive nuclide 225 Ac is one of the few promising candidates for cancer treatment by targeted- α -therapy, but worldwide production of 225 Ac faces significant limitations. In this work, the Isotope Separation On-Line method was used to produce actinium by irradiating targets made of uranium carbide and thorium carbide with 1.4-GeV protons. Actinium fluoride molecules were formed, ionized through electron impact, then extracted and mass-separated as a beam of molecular ions. The composition of the mass-selected ion beam was verified using time-of-flight mass spectrometry, α - and γ -ray decay spectrometry. Extracted quantities of 225 Ac 19 F 2 + particles per μ C of incident protons were 3.9 ( 3 ) × 10 7 from a uranium carbide target and 4.3 ( 4 ) × 10 7 for a thorium carbide target. Using a magnetic mass separator, the long-lived contamination 227 Ac is suppressed to < 5.47 × 10 - 7 (95% confidence interval) with respect to 225 Ac by activity. Measured rates scale to collections of 108 kBq μ A - 1 h - 1 of directly produced 225 Ac 19 F 2 + .

Objectives Differences between country-specific guidelines for economic evaluations complicate the execution of international economic evaluations. The aim of this study was to develop cross-European recommendations for the identification, measurement and valuation of resource use and lost productivity in economic evaluations using a Delphi procedure. Methods A comprehensive literature search was conducted to identify European guidelines on the execution of economic evaluations or costing studies as part of economic evaluations. Guideline recommendations were extracted by two independent reviewers and formed the basis for the first round of the Delphi study, which was conducted among European health economic experts. During three written rounds, consensus (agreement of 67% or higher) was sought on items concerning the identification, measurement and valuation of costs. Results Recommendations from 18 guidelines were extracted. Consensus among 26 panellists from 17 European countries was reached on 61 of 68 items. The recommendations from the Delphi study are to adopt a societal perspective, to use patient report for measuring resource use and lost productivity, to value both constructs with use of country-specific standardized/ unit costs and to use country-specific discounting rates. Conclusion This study provides consensus-based cross-European recommendations on how to measure and value resource use and lost productivity in economic evaluations. These recommendations are expected to support researchers, healthcare professionals, and policymakers in executing and appraising economic evaluations performed in international contexts.

Beta - neutrino correlation measurements are key in the research of physics beyond the Standard Model. In pure Fermi beta transitions, the beta-neutrino correlation coefficient, aβν, is sensitive to the presence of scalar currents. The present limits were established by experimental studies of various nuclear systems with allowed Fermi transitions. A new experiment to improve the constraints on scalar currents is being developed, by the WISArD collaboration at ISOLDE/CERN, where the aim is to measure the energy shift of the β-delayed protons emitted from the isobaric analogue state of the 32Ar ground state. To enhance the sensitivity, protons and positrons are guided by a strong magnetic field and measured in coincidence between the two detection configurations located on both sides of a catcher foil in which the radioactive samples are implanted. Kinematic energy shifts of the protons in coincidence with positrons, in the same or opposite hemisphere of the catcher foil, will be more or less pronounced as a function of the possible scalar current component of the weak interaction. Details of the apparatus and preliminary results of the experiment are presented.

The aim of this study is to further develop a preliminary framework into a model that can translate mechanisms into output and impact, based on the views of those working in practice and the relations between the mechanisms: a model that can inform practitioners and organizations on what has to be in place to shape a learning and innovating environment in nursing. A Learning and Innovation Network (LIN) is a network of healthcare professionals, students and education representatives who come together to be part of a nursing community to integrate education, research and practice to contribute to quality of care. In a previous study a preliminary framework was developed through a concept analysis based on publications. The preliminary framework describes input, throughput and output factors in a linear model that does not explain what the components entail in practice and how the components work together. Focus groups. We designed a Theory of Change (ToC) in four phases. This was based on a focus group interview with lecturer practitioners (Phase 1); a first concept ToC based on thematic analysis of the focus group interview (Phase 2); three paired interviews where the ToC was presented to other lecturer practitioners to complement and verify the ToC model (Phase 3); and adjustment of the model based on the feedback of phase 3 (Phase 4). The developed ToC model describes important preconditions that have to be in place to start a LIN: a shared vision, a facilitating support system and a diversity of participants who are open to change. It describes the mechanisms by which a wide range of activities can lead to an improvement of the quality of care through collaboration between practice, education and research by working, learning, performing practice based research and implementing new methods together. This study gives a comprehensive overview of the concept of the ‘Learning and Innovation Network’ (LIN); how the activities in the LIN can lead to impact; and under what conditions. Previously published findings supported elements of the ToC model. The overarching ToC model and the detailed appendix offer a theoretical and practice-based model for practitioners, managers and policy makers.

The radioactive nuclide .sup.225Ac is one of the few promising candidates for cancer treatment by targeted- [Formula omitted]-therapy, but worldwide production of .sup.225Ac faces significant limitations. In this work, the Isotope Separation On-Line method was used to produce actinium by irradiating targets made of uranium carbide and thorium carbide with 1.4-GeV protons. Actinium fluoride molecules were formed, ionized through electron impact, then extracted and mass-separated as a beam of molecular ions. The composition of the mass-selected ion beam was verified using time-of-flight mass spectrometry, [Formula omitted]- and [Formula omitted]-ray decay spectrometry. Extracted quantities of [Formula omitted] particles per [Formula omitted]C of incident protons were [Formula omitted] from a uranium carbide target and [Formula omitted] for a thorium carbide target. Using a magnetic mass separator, the long-lived contamination .sup.227 Ac is suppressed to [Formula omitted] (95% confidence interval) with respect to .sup.225Ac by activity. Measured rates scale to collections of 108 kBq [Formula omitted]A [Formula omitted]h [Formula omitted] of directly produced [Formula omitted].

Eugenic Fantasies is an innovative work that combines interpretive strategies from the fields of psychoanalysis, anthropology, and literary studies to create a new model for theorizing race.

Highly accurate and precise electronic structure calculations of heavy radioactive atoms and their molecules are important for several research areas, including chemical, nuclear, and particle physics. Ab initio quantum chemistry can elucidate structural details in these systems that emerge from the interplay of relativistic and electron correlation effects, but the large number of electrons complicates the calculations, and the scarcity of experiments prevents insightful theory-experiment comparisons. Here we report the spectroscopy of the 14 lowest excited electronic states in the radioactive molecule radium monofluoride (RaF), which is proposed as a sensitive probe for searches of new physics. The observed excitation energies are compared with state-of-the-art relativistic Fock-space coupled cluster calculations, which achieve an agreement of ≥99.64% (within  ~12 meV) with experiment for all states. Guided by theory, a firm assignment of the angular momentum and term symbol is made for 10 states and a tentative assignment for 4 states. The role of high-order electron correlation and quantum electrodynamics effects in the excitation energies is studied and found to be important for all states. Heavy-atom molecules can possess complicated electronic structures due to pronounced electron correlation and relativistic effects. Here, the authors describe electronic states of RaF in detail by combining accurate spectroscopy and theory approaches.

The radioactive nuclide Ac is one of the few promising candidates for cancer treatment by targeted- -therapy, but worldwide production of Ac faces significant limitations. In this work, the Isotope Separation On-Line method was used to produce actinium by irradiating targets made of uranium carbide and thorium carbide with 1.4-GeV protons. Actinium fluoride molecules were formed, ionized through electron impact, then extracted and mass-separated as a beam of molecular ions. The composition of the mass-selected ion beam was verified using time-of-flight mass spectrometry, - and -ray decay spectrometry. Extracted quantities of particles per C of incident protons were from a uranium carbide target and for a thorium carbide target. Using a magnetic mass separator, the long-lived contamination Ac is suppressed to (95% confidence interval) with respect to Ac by activity. Measured rates scale to collections of 108 kBq A h of directly produced .

Although aromatic compounds are most often present in the environment as components of complex mixtures, biodegradation studies commonly focus on the degradation of individual compounds. The present study was performed to investigate the range of aromatic substrates utilized by biphenyl- and naphthalene-degrading environmental isolates and to ascertain the effects of co-occurring substrates during the degradation of mono-aromatic compounds. Bacterial strains were isolated on the basis of their ability to utilize either biphenyl or naphthalene as a sole source of carbon. Growth and transformation assays were conducted on each isolate to determine the range of substrates degraded. One isolate, Pseudomonas putida BP18, was tested for the ability to biodegrade benzene, toluene, ethylbenzene and xylene isomers (BTEX) individually and as components of mixtures. Overall, the results indicate that organisms capable of growth on multi-ring aromatic compounds may be particularly versatile in terms of aromatic hydrocarbon biodegradation. Furthermore, growth and transformation assays performed with strain BP18 suggest that the biodegradation of BTEX and biphenyl by this strain is linked to a catabolic pathway with overlapping specificities. The broad substrate specificity of these environmental isolates has important implications for bioremediation efforts in the field.

Accelerator-based techniques are one of the leading ways to produce radioactive nuclei. In this work, the Isotope Separation On-Line method was employed at the CERN-ISOLDE facility to produce neptunium and plutonium from a uranium carbide target material using 1.4-GeV protons. Neptunium and plutonium were laser-ionized and extracted as 30-keV ion beams. A Multi-Reflection Time-of-Flight mass spectrometer was used for ion identification by means of time-of-flight measurements as well as for isobaric separation. Isotope shifts were investigated for the 395.6-nm ground state transition in \\(^{236,237,239}\\)Np and the 413.4-nm ground state transition in \\(^{236,239,240}\\)Pu. Rates of \\(^{235-241}\\)Np and \\(^{234-241}\\)Pu ions were measured and compared with predictions of in-target production mechanisms simulated with GEANT4 and FLUKA to elucidate the processes by which these nuclei, which contain more protons than the target nucleus, are formed. \\(^{241}\\)Pu is the heaviest nuclide produced and identified at a proton-accelerator-driven facility to date. We report the availability of neptunium and plutonium as two additional elements at CERN-ISOLDE and discuss the limit of accelerator-based isotope production at high-energy proton accelerator facilities for nuclides in the actinide region.