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Existing ice particle jet surface treatment technology is prone to ice particle adhesion during application, significantly affecting surface treatment efficiency. Based on the basic structure of the jet pump, the ice particle air jet surface treatment technology is proposed for the instant preparation and utilization of ice particles, solving the problem of ice particle adhesion and clogging. To achieve efficient utilization of ice particles and high-speed jetting, an integrated jet structure for ice particle ejection and acceleration was developed. The influence of the working nozzle position ( L d ), expansion ratio ( n ), and acceleration nozzle diameter ratio ( D n ) length-to-diameter ratio ( L n ) on the ice particle ejection and acceleration was systematically studied. The structural parameters of the ejector were determined using the impact kinetic energy of ice particles as the comprehensive evaluation index, and the surface treatment test was conducted to verify the results. The study shows that under 2 MPa air pressure, the ejector nozzle parameters of n  = 1.5, D n  = 4.0, L d  = 4, and L n  = 0 mm can effectively eject and accelerate the ice particles. The aluminum alloy plate depainting test obtained a larger paint removal radius and resulted in a smoother aluminum alloy plate surface, reducing the surface roughness from 3.194 ± 0.489 μm to 1.156 ± 0.136 μm. The immediate preparation and utilization of ice particles solved the problems of adhesion and storage in the engineering application of ice particle air jet technology, providing a feasible technical method in the field of material surface treatment.

Arsenic exposure model of offspring mice was established and intervened with 6-chlorobenzo[d]isoxazol-3-ol (CBIO), a D-amino acid oxidase (DAAO) inhibitor, to explore the role of DAAO in cognitive impairment of offspring mice induced by arsenic during early developmental stage. Female mice and their pups treated with 0 or 60 mg/L sodium arsenite (NaAsO 2 ) via drinkable water from the first day of gestation till the end of lactation. On the 28th day after birth, the offspring mice in the drinking distilled water group were randomly divided into control and 1 mg/mL CBIO group. The offspring mice in the arsenic group were divided into 60 mg/L NaAsO 2 group and 60 mg/L NaAsO 2  + 1 mg/mL CBIO group, CBIO was administered to the lateral ventricle for one week. Additionally, D-serine and L-serine concentrations were detected by UHPLC-MS/MS, Real-time RT-PCR and Western blot were applied to measure DAAO, serine racemase (SR), N-methyl-D-aspartate receptor (NMDAR), synaptophysin (SYP) and postsynaptic density (PSD95) levels in the hippocampus. Results disclosed that arsenic could reduce the levels of D-serine, L-serine, SR and NMDAR, while upregulate DAAO levels, however, inhibiting DAAO levels could increase D-serine and NR1 levels. These findings indicated that DAAO might be involved in cognitive impairment of offspring mice induced by arsenic during early developmental stage by affecting D-serine metabolism.

In China, six species of Statherotmantis Diakonoff, 1973 were previously recorded. In the present study, four other species were recognized using morphology and DNA barcording analysis. Among these, three of which, S. miniscula sp. n., S. calva sp. n., and S. longiuscula sp. n., are described as new. In addition, one species, S. laetana Kuznetzov, 1988, is a new record for China. Adults and genitalia are illustrated, and keys to identify the Chinese species of Statherotmantis are provided. In the present study, three new species and one new record are recognized using morphology and DNA barcording analysis.

To investigate the control factors of mine disasters induced by high ground pressure, this paper takes a longwall face of Pingdingshan No. 10 coal mine as the engineering background. By employing the analytical model and numerical simulation methods, this study quantified the movement characteristics of the hard roof strata and the evolution of mining-induced stress. The control mechanisms of various geological factors on the distribution of the abutment pressure were evaluated. The results indicate that (1) the PFC-FLAC coupled numerical model can effectively simulate and predict the characteristics of roof collapse and the distribution characteristics of abutment pressure. (2) The first weighting distance, the peak of the abutment pressure, and the influence range of the abutment pressure can be measured by the proposed model, whereas the periodic weighting barely can be observed. (3) The tensile strength and thickness of the hard roof directly control the peak value of the abutment pressure and the first weighting distance. As the strength and thickness of the hard roof increase, both the peak value and influence distance of the abutment pressure significantly increase. When the tensile strength of the hard roof reaches a high value, the development of fractures in the hard roof shows a clear periodicity pattern. The vertical stress significantly affects the movement and fracturing of the overburden, while the horizontal stress has a limited impact on the movement and fracturing of the overburden. The proposed methods provide technical guidance and theoretical support for controlling ground pressure in deep-buried longwall faces.

In recent years, tunnel-boring machines (TBMs) have been widely applied in deep coal mining. Turning is an inevitable challenge in TBM tunneling, and a TBM turning roadway exhibits greater instability than a straight roadway, as engineering experience has indicated. This study aimed to explore the failure mechanism and evaluate the support performance of a deep-turning roadway. Several numerical models were established to investigate the deformation of the roadway, the stress distribution, and the failure zone of the surrounding rocks under different tunneling conditions. The results show that the tunneling depth influences the failure pattern of the turning roadway: deep tunneling with high in situ stress can cause asymmetric failure of the turning roadway, while shallow tunneling with low in situ stress does not. Moreover, the change in turning radius, namely the change in roadway geometry, does not influence the stability of the turning roadway. In addition, the support actions for both the straight and turning roadways do not differ significantly, and the amount of controlled deformation of the surrounding rocks is proportional to their natural deformation.

Recently, the increase in marine temperatures has become an important global marine environmental issue. The ability of energy supply in marine animals plays a crucial role in avoiding the stress of elevated temperatures. The investigation into anaerobic metabolism, an essential mechanism for regulating energy provision under heat stress, is limited in mollusks. In this study, key enzymes of four anaerobic metabolic pathways were identified in the genome of scallop Chlamys farreri, respectively including five opine dehydrogenases (CfOpDHs), two aspartate aminotransferases (CfASTs) divided into cytoplasmic (CfAST1) and mitochondrial subtype (CfAST2), and two phosphoenolpyruvate carboxykinases (CfPEPCKs) divided into a primitive type (CfPEPCK2) and a cytoplasmic subtype (CfPEPCK1). It was surprising that lactate dehydrogenase (LDH), a key enzyme in the anaerobic metabolism of the glucose–lactate pathway in vertebrates, was absent in the genome of scallops. Phylogenetic analysis verified that CfOpDHs clustered according to the phylogenetic relationships of the organisms rather than substrate specificity. Furthermore, CfOpDHs, CfASTs, and CfPEPCKs displayed distinct expression patterns throughout the developmental process and showed a prominent expression in muscle, foot, kidney, male gonad, and ganglia tissues. Notably, CfASTs displayed the highest level of expression among these genes during the developmental process and in adult tissues. Under heat stress, the expression of CfASTs exhibited a general downregulation trend in the six tissues examined. The expression of CfOpDHs also displayed a downregulation trend in most tissues, except CfOpDH1/3 in striated muscle showing significant up-regulation at some time points. Remarkably, CfPEPCK1 was significantly upregulated in all six tested tissues at almost all time points. Therefore, we speculated that the glucose–succinate pathway, catalyzed by CfPEPCK1, serves as the primary anaerobic metabolic pathway in mollusks experiencing heat stress, with CfOpDH3 catalyzing the glucose–opine pathway in striated muscle as supplementary. Additionally, the high and stable expression level of CfASTs is crucial for the maintenance of the essential functions of aspartate aminotransferase (AST). This study provides a comprehensive and systematic analysis of the key enzymes involved in anaerobic metabolism pathways, which holds significant importance in understanding the mechanism of energy supply in mollusks.

Recently, the increase in marine temperatures has become an important global marine environmental issue. The ability of energy supply in marine animals plays a crucial role in avoiding the stress of elevated temperatures. The investigation into anaerobic metabolism, an essential mechanism for regulating energy provision under heat stress, is limited in mollusks. In this study, key enzymes of four anaerobic metabolic pathways were identified in the genome of scallop Chlamys farreri, respectively including five opine dehydrogenases (CfOpDHs), two aspartate aminotransferases (CfASTs) divided into cytoplasmic (CfAST1) and mitochondrial subtype (CfAST2), and two phosphoenolpyruvate carboxykinases (CfPEPCKs) divided into a primitive type (CfPEPCK2) and a cytoplasmic subtype (CfPEPCK1). It was surprising that lactate dehydrogenase (LDH), a key enzyme in the anaerobic metabolism of the glucose–lactate pathway in vertebrates, was absent in the genome of scallops. Phylogenetic analysis verified that CfOpDHs clustered according to the phylogenetic relationships of the organisms rather than substrate specificity. Furthermore, CfOpDHs, CfASTs, and CfPEPCKs displayed distinct expression patterns throughout the developmental process and showed a prominent expression in muscle, foot, kidney, male gonad, and ganglia tissues. Notably, CfASTs displayed the highest level of expression among these genes during the developmental process and in adult tissues. Under heat stress, the expression of CfASTs exhibited a general downregulation trend in the six tissues examined. The expression of CfOpDHs also displayed a downregulation trend in most tissues, except CfOpDH1/3 in striated muscle showing significant up-regulation at some time points. Remarkably, CfPEPCK1 was significantly upregulated in all six tested tissues at almost all time points. Therefore, we speculated that the glucose–succinate pathway, catalyzed by CfPEPCK1, serves as the primary anaerobic metabolic pathway in mollusks experiencing heat stress, with CfOpDH3 catalyzing the glucose–opine pathway in striated muscle as supplementary. Additionally, the high and stable expression level of CfASTs is crucial for the maintenance of the essential functions of aspartate aminotransferase (AST). This study provides a comprehensive and systematic analysis of the key enzymes involved in anaerobic metabolism pathways, which holds significant importance in understanding the mechanism of energy supply in mollusks.

Coal is the main energy source in China. In the process of coal resource mining, the surrounding rock of roadways is often in the complex stress environment of “three heights and one disturbance”. At the same time, rocks in the stratum are often in a three-way unequal pressure state under the action of geological structure, and conventional rock mechanics tests cannot study the mechanical properties of rocks under actual stress conditions; thus, this is based on the self-developed true triaxial multifunctional fluid–structure coupling test system to study the damage mechanical Properties of Sandstone. The results are shown as follows: With an increase in loading rate, the peak damage Dcr of sandstone decreases, but the initial damage Da increases in the elastic stage, and the brittleness of sandstone weakens. With the increase in the unloading rate, Dcr increases, but Da decreases in the elastic stage, and the sandstone brittleness increases first, then decreases. In addition, the peak maximum principal strain ε1maxfirst decreases rapidly and then slowly; the peak minimum principal strain ε3max increases first, then decreases slowly, and increases slowly; the peak intermediate principal strain ε2max decreases slowly; and the peak volume strain εvmax increases rapidly first and then slowly with increases in the loading rate. With an increase in the unloading rate, ε1max increases rapidly first, then decreases slowly, then increases rapidly and finally increases slowly; ε3max first decreases slowly, then increases slowly, and finally decreases slowly; and ε2max increases slowly then decreases slowly. εvmax decreases rapidly first and then increases slowly with increasing loading rate.

To investigate the variations in wave velocity fields between impact and outburst coal seams, we analyzed the fluctuations in wave velocity under loading conditions for both coal types. A comprehensive methodology was developed to correct coal wave velocities in response to stress and gas presence, which was then applied to field assessments of hazardous regions. Our findings reveal significant differences in wave velocity alterations between impact and outburst coal seams during loading-induced failure. Gas pressure exhibits a negative correlation with wave velocity in outburst coal (correlation coefficient R2 = 0.86), whereas wave velocity in impact coal demonstrates a positive correlation with stress (R2 = 0.63). A robust methodology for correcting coal wave velocities in response to stress and gas presence was established to enable more accurate measurement of wave velocity changes. In field applications, seismic wave computed tomography identified stress anomalies that closelycorresponded with geological structures and mining operations, effectively pinpointing hazardous zones. The abnormal wave velocity coefficient ranges for outburst coal seams and impact coal seams are −0.6 to 0.25 and −0.35 to 0.16, respectively, which correspond well with the field stress distribution.

Stomach adenocarcinoma (STAD) is one of the most commonly diagnosed cancers. This study analyzed the subtypes and characteristics of STAD subtypes by analyzing hypoxia pathway-related lncRNAs. Potential hub lncRNAs were found and a prognostic model was constructed. Expression profiling data and clinical information of STAD were obtained from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO). Metabolic pathway scores were calculated using single-sample gene set enrichment analysis (ssGSEA) method. Tumor immune microenvironment scores of the samples were assessed by ESTIMATE, MCP-counter, and ssGSEA. Functional analysis of lncRNAs, construction of risk models, and drug sensitivity analysis were performed. Pathway analysis revealed that the hypoxia pathway was a prognostic risk factor. Molecular subtypes were developed based on the hypoxia score-related lncRNAs. Three molecular subtypes (C1, C2, and C3) for gastric STAD were determined. The worst prognosis was in the C2, which was also characterized by the maximum hypoxia pathway-related scores and the maximum immune score. A majority of the immune checkpoints and chemokines were high-expressed in the C2 subtype. Mutations in the C2 subtype were significantly lower than the C1 and C3 subtypes. The subtypes differed in terms of functional and metabolic pathways. Eight hub indicator lncRNAs (MSC-AS1, AC037198.1, LINC00968, AL139393.3, LINC02544, BOLA3-AS1, MIR1915HG, and AC107021.2) capable of predicting patient prognosis were identified. Three hypoxia lncRNA-related molecular subtypes characterized by different prognostic and immune conditions were identified. The results maybe can provide a theoretical basis to improve the clinical diagnosis and treatment of STAD.