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Posterior tibial tendon (PTT) dysfunction is three times more common in females, and some patients may have a predisposition without a clinically evident cause, suggesting that individual characteristics play an important role in tendinopathy. The present study investigated the association of rs4986938 (+ 1730G > A; AluI RFLP) and rs1256049 (− 1082G > A; RsaI RFLP) single nucleotide polymorphisms (SNPs) of estrogen receptor-beta (ER-β) gene with PTT dysfunction. A total of 400 participants were recruited. The PTT dysfunction group: these patients underwent surgery, with PTT tendinopathy confirmed by histopathology and magnetic resonance image (MRI). The control group was composed of participants with no clinical or MRI evidence of PTT dysfunction. Each group was composed of 100 postmenopausal women, 50 premenopausal women, and 50 men. Genomic DNA was extracted from saliva samples, and genotypes were obtained by polymerase chain reaction restriction fragment length polymorphism (PCR–RFLP). Concerning the ER-β SNP rs4986938, there were significant differences in the frequencies of alleles between test and control groups of all the cases, only postmenopausal women and only men (p < 0.0001, p = 0.0016 and p = 0.0001). Considering the PTT dysfunction group and comparing postmenopausal women versus premenopausal women adding men, the analysis showed significant differences in the allelic distribution (p = 0.0450): the allele A in postmenopausal women is a risk factor. The ER-β SNP rs1256049 did not show differences in the frequencies of alleles and genotypes between groups. The ER-β SNP rs4986938, but not ER -β SNPs rs1256049, may contribute to PTT insufficiency in the Brazilian population, with additional risk in postmenopausal women. Addition, in men the genetic factor could be more determinant.

HERMES-Pathfinder is a space-borne mission based on a constellation of six nano-satellites flying in a low-Earth orbit. The 3U CubeSats, to be launched in early 2025, host miniaturized instruments with a hybrid Silicon Drift Detector/scintillator photodetector system, sensitive to both X-rays and gamma-rays. A seventh payload unit is installed onboard SpIRIT, an Australian-Italian nano-satellite developed by a consortium led by the University of Melbourne and launched in December 2023. The project aims at demonstrating the feasibility of Gamma-Ray Burst detection and localization using miniaturized instruments onboard nano-satellites. The HERMES flight model payloads were exposed to multiple well-known radioactive sources for spectroscopic calibration under controlled laboratory conditions. The analysis of the calibration data allows both to determine the detector parameters, necessary to map instrumental units to accurate energy measurements, and to assess the performance of the instruments. We report on these efforts and quantify features such as spectroscopic resolution and energy thresholds, at different temperatures and for all payloads of the constellation. Finally we review the performance of the HERMES payload as a photon counter, and discuss the strengths and the limitations of the architecture.

Background Posterior tibial tendon (PTT) insufficiency is considered as the main cause of adult acquired flat foot and is three times more frequent in females. High estrogen levels exert a positive effect on the overall collagen synthesis in tendons. We have previously demonstrated the association between some genetic single-nucleotide polymorphism (SNP) and tendinopathy. In the present study, we investigated the association of PvuII c454-397T>C (NCBI ID: rs2234693) and XbaI c454-351A>G (NCBI ID: rs9340799) SNPs in estrogen receptor alfa (ER-α) gene with PPT dysfunction. Methods A total of 92 female subjects with PTT dysfunction, with histopathological examination of the tendon and magnetic resonance image (MRI) evidence of tendinopathy, were compared to 92 asymptomatic females who presented an intact PPT at MRI for PvuII and XbaI SNPs in the ER-α gene. Genomic DNA was extracted from saliva and genotypes were obtained by polymerase chain reaction restriction fragment length polymorphism. Results The analysis of PvuII SNPs showed no significant differences in the frequency of alleles and genotypes between control and PTT dysfunction groups. The XbaI SNPs in the ER-α gene showed significant differences in the frequency of genotypes between control and test groups ( p  = 0.01; OR 95% 1.14 (0.55–2.33). Conclusions The XbaI SNP in the ERα gene may contribute to tendinopathy, and the A/A genotype could be a risk factor for PTT tendinopathy in this population. The PvuII SNP studied was not associated with PTT tendinopathy.

Purpose We investigated the frequency of cervical intraepithelial neoplasia (CIN) grade II or worse in low-income Brazilian women with persistent low-grade squamous intraepithelial lesions (LSIL). Methods A retrospective review of medical records was performed for all patients who underwent a loop electrosurgical excision procedure (LEEP) with \"see and treat\" strategy for persistent LSIL seen on Papanicolaou (Pap) smears (persisting >12 months in at least two consecutive tests, over a 50-month period. We assessed the colposcopy and histopathology results at the time of the procedure and at follow-up, using Pap and histopathology. Results Of 106 women, 48 (45.3 %) had no dysplasia by histopathology, 18 (17.0 %) had CIN I, 29 (27.4 %) had CIN II and 10 (9.4 %) had CIN III. Among the patients with CIN, 38 (66.7 %) performed the follow-up. Of these, only 4 (10.5 %) were classified as follow-up (+), all had CIN I. Women with initial CIN I had 16.7 % ( n  = 2) recurrences; those with initial CIN II had 5.9 % ( n  = 1); and those with initial CIN III had 11.1 % ( n  = 1) ( p  > 0.05). Conclusions A very high proportion of the women with persistent LSIL had CIN II/III on post-LEEP histopathology. Recurrence rates were equal to than those that originally caused the patients to be subjected to LEEP (LSIL). The benefits of the \"see and treat\" protocol by LEEP for persistent LSIL outweigh the risk of overtreatment, principally in low-resource settings where poor patient compliance is expected, as in Brazil.

Posterior tibial tendon (PTT) insufficiency is considered as the main cause of adult acquired flat foot and is three times more frequent in females. High estrogen levels exert a positive effect on the overall collagen synthesis in tendons. We have previously demonstrated the association between some genetic single-nucleotide polymorphism (SNP) and tendinopathy. In the present study, we investigated the association of PvuII c454-397T>C (NCBI ID: rs2234693) and XbaI c454-351A>G (NCBI ID: rs9340799) SNPs in estrogen receptor alfa (ER-[alpha]) gene with PPT dysfunction. A total of 92 female subjects with PTT dysfunction, with histopathological examination of the tendon and magnetic resonance image (MRI) evidence of tendinopathy, were compared to 92 asymptomatic females who presented an intact PPT at MRI for PvuII and XbaI SNPs in the ER-[alpha] gene. Genomic DNA was extracted from saliva and genotypes were obtained by polymerase chain reaction restriction fragment length polymorphism. The analysis of PvuII SNPs showed no significant differences in the frequency of alleles and genotypes between control and PTT dysfunction groups. The XbaI SNPs in the ER-[alpha] gene showed significant differences in the frequency of genotypes between control and test groups (p = 0.01; OR 95% 1.14 (0.55-2.33). The XbaI SNP in the ER[alpha] gene may contribute to tendinopathy, and the A/A genotype could be a risk factor for PTT tendinopathy in this population. The PvuII SNP studied was not associated with PTT tendinopathy.

Objectives To evaluate the histology of the loop electrosurgical excision procedure (LEEP) surgical tissues of patients with ASC-H and post-LEEP recurrence. Methods Medical records of patients with ASC-H treated with LEEP between January 2004 and March 2008 in the town of União da Vitória, Paraná, seat of the Sixth Public Health Region of Paraná (CISVALI), were evaluated. The LEEP was carried out solely for ASC-H immediately after colposcopy, but without a histological diagnosis. Results Most patients were less than 40 years old (71.1%), with the largest group 20–39 years old ( p  < 0.0001). Twenty-eight patients (73.3%) showed histological lesions. Cervical intraepithelial neoplasias (CIN) I was present in 7 (18.4%), CIN II and CIN III in 9 (23.7%) each, microinvasive squamous cell carcinoma (SCMCA) in 2 (5.3%), and SCMCA plus in situ adenocarcinoma in 1 (2.2%). In 32 patients (84.2%), there was no involvement of the margins, including 100% with no dysplasia histology and CIN I, 80.0% of those with CIN II, and 88.9% of those with CIN III. Two patients (5.3%) had endocervical involvement, all of them with CIN II. Four patients (10.5%) had ectocervical and endocervical involvement, one of them with CIN III, and three of them with carcinomas. All patients with follow-up (+) were ASC-US, with no patients with dysplasia or CIN I. Conclusions A very high portion of the women with ASC-H had lesions on post-LEEP histological examination, principally CIN II and III. These data show the benefits of treatment for ASC-H by LEEP immediately after colposcopy but without any previous histology.

HERMES (High Energy Rapid Modular Ensemble of Satellites) Pathfinder mission aims to observe and localize Gamma Ray Bursts (GRBs) and other transients using a constellation of nanosatellites in low-Earth orbit (LEO). Scheduled for launch in early 2025, the 3U CubeSats will host miniaturized instruments featuring a hybrid Silicon Drift Detector (SDD) and GAGG:Ce scintillator photodetector system, sensitive to X-rays and gamma-rays across a wide energy range. Each HERMES payload contains 120 SDD cells, each with a sensitive area of 45 mm^2, organized into 12 matrices, reading out 60 12.1x6.94x15.0 mm^3 GAGG:Ce scintillators. Photons interacting with an SDD are identified as X-ray events (2-60 keV), while photons in the 20-2000 keV range absorbed by the crystals produce scintillation light, which is read by two SDDs, allowing event discrimination. The detector system, including front-end and back-end electronics, a power supply unit, a chip-scale atomic clock, and a payload data handling unit, fits within a 10x10x10 cm^3 volume, weighs 1.5 kg, and has a maximum power consumption of about 2 W. This paper outlines the development of the HERMES constellation, the design and selection of the payload detectors, and laboratory testing, presenting the results of detector calibrations and environmental tests to provide a comprehensive status update of the mission.

The High Energy Rapid Modular Ensemble of Satellites (HERMES) instrument is a compact X/\\(\\gamma\\)-ray spectrometer operating on board the 6U (11 kg) SpIRIT CubeSat. The payload is particularly well suited for the observation of cosmic transients such as Gamma-Ray Bursts and bright pulsars thanks to its unique broadband sensitivity from a few keV to a few MeV and the temporal resolution down to half a microsecond. We report here the detection of the \\(\\sim\\)33~ms Crab pulsar double-peaked pulse profile obtained by considering the canonical Crab ephemerides as provided by the Jodrell Bank catalog. We collected approximately 5.7\\(\\cdot\\)10\\(^4\\) photons from 730~s of observations, in the 3 keV -- 2 MeV energy band, during a single operation, and achieved a 5\\(\\sigma\\) pulse profile significance in the 3--11.5 keV energy band with binning at the ms scale. The results demonstrate that SpIRIT/HERMES can achieve millisecond timing accuracy at high energies and, thanks to its wide field of view and broad energy band, has the potential to contribute to GRB monitoring in the near future. Such capabilities were previously the domain of flagship observatories, underscoring the performance of the HERMES instrument with its compact form factor.

Gamma Ray Bursts (GRBs) bridge relativistic astrophysics and multi-messenger astronomy. Space-based gamma/X-ray wide field detectors have proven essential to detect and localize the highly variable GRB prompt emission, which is also a counterpart of gravitational wave events. We study the capabilities to detect long and short GRBs by the High Energy Rapid Modular Ensemble of Satellites (HERMES) Pathfinder (HP) and SpIRIT, namely a swarm of six 3U CubeSats to be launched in early 2025, and a 6U CubeSat launched on December 1st 2023. We also study the capabilities of two advanced configurations of swarms of >8 satellites with improved detector performances (HERMES Constellations). The HERMES detectors, sensitive down to ~2-3 keV, will be able to detect faint/soft GRBs which comprise X-ray flashes and high redshift bursts. By combining state-of-the-art long and short GRB population models with a description of the single module performance, we estimate that HP will detect ~195^{+22}_{-21} long GRBs (3.4^{+0.3}_{-0.8} at redshift z>6) and ~19^{+5}_{-3} short GRBs per year. The larger HERMES Constellations under study can detect between ~1300 and ~3000 long GRBs per year and between ~160 and ~400 short GRBs per year, depending on the chosen configuration, with a rate of long GRBs above z>6 between 30 and 75 per year. Finally, we explore the capabilities of HERMES to detect short GRBs as electromagnetic counterparts of binary neutron star (BNS) mergers detected as gravitational signals by current and future ground-based interferometers. Under the assumption that the GRB jets are structured, we estimate that HP can provide up to 1 (14) yr^{-1} joint detections during the fifth LIGO-Virgo-KAGRA observing run (Einstein Telescope single triangle 10 km arm configuration). These numbers become 4 (100) yr^{-1}, respectively, for the HERMES Constellation configuration.

The High Energy Rapid Modular Ensemble of Satellites (HERMES) Technological and Scientific pathfinder is a space borne mission based on a constellation of LEO nanosatellites. The payloads of these CubeSats consist of miniaturized detectors designed for bright high-energy transients such as Gamma-Ray Bursts (GRBs). This platform aims to impact Gamma Ray Burst (GRB) science and enhance the detection of Gravitational Wave (GW) electromagnetic counterparts. This goal will be achieved with a field of view of several steradians, arcmin precision and state of the art timing accuracy. The localization performance for the whole constellation is proportional to the number of components and inversely proportional to the average baseline between them, and therefore is expected to increase as more. In this paper we describe the Payload Data Handling Unit (PDHU) for the HERMES-TP and HERMES SP mission. The PDHU is the main interface between the payload and the satellite bus. The PDHU is also in charge of the on-board control and monitoring of the scintillating crystal detectors. We will explain the TM/TC design and the distinct modes of operation. We also discuss the on-board data processing carried out by the PDHU and its impact on the output data of the detector.