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Climate extremes such as droughts and heatwaves have a large impact on terrestrial carbon uptake by reducing gross primary production (GPP). While the evidence for increasing frequency and intensity of climate extremes over the last decades is growing, potential systematic adverse shifts in GPP have not been assessed. Using observationally-constrained and process-based model data, we estimate that particularly northern midlatitude ecosystems experienced a +10.6% increase in negative GPP extremes in the period 2000–2016 compared to 1982–1998. We attribute this increase predominantly to a greater impact of warm droughts, in particular over northern temperate grasslands (+95.0% corresponding mean increase) and croplands (+84.0%), in and after the peak growing season. These results highlight the growing vulnerability of ecosystem productivity to warm droughts, implying increased adverse impacts of these climate extremes on terrestrial carbon sinks as well as a rising pressure on global food security.The authors show increased negative extremes in gross primary productivity in northern midlatitude ecosystems, particularly over grasslands and croplands, attributed to impacts of warm droughts. This highlights the vulnerability of terrestrial carbon sinks and food security to increasing extreme events.

This article examines the subject of Ottoman shipping in the Indian Ocean in the two and a half centuries after 1650. With reference to both Ottoman and European sources, it first grapples with the empirical problems involved in studying the subject. It then explores how a combination of trade dynamics in the Gulf and the economic preferences of both Ottoman state and private actors attenuated the expansion of Ottoman shipping. Taken together, these factors confirm that the comparative dearth of Ottoman vessels in the Indian Ocean trade was a product of geopolitical and ecological contingency rather than entrepreneurial neglect or state aversion. Even so, as shown by two case studies, Ottoman subjects of one type or another were found in ports from Surat to Batavia at various moments before 1800. The analysis then turns to later nineteenth-century attempts by Ottoman state actors to augment Ottoman shipping. These efforts were inhibited by the contrasting incentives of private Ottoman seafarers, the dominance of European and Indian ships in the empire’s trade with India, the dislocation of nominal Ottoman territories in the Gulf, and the political economy of the Ottoman Gulf itself. Despite the fact that state-sponsored shipping came to grief, the presence of Ottoman ships in the Indian Ocean invites reflections on the highly mutable character of Ottoman identity and sovereignty, as well as the empire’s relative position in the wider commercial world of the Indian Ocean, across these centuries.

This article examines Ottoman–Portuguese commercial agreements in Basra during the century after 1622 and the legal ambiguities that they engendered. On two separate occasions, the Portuguese established a factory in Basra: first in 1624 during the reign of the Afrāsiāb pasha (who governed in the name of the Ottomans from 1612 to 1667) and once again in 1690 when the city was ruled again by Ottoman governors (Ottoman direct rule was restored in 1667). Yet there were myriad issues that supplied cause for disputation between the two parties, not least the legal status of the factory itself. On the face of it, both the Portuguese and the Ottoman functionaries in Basra operated according to divergent models of extraterritorial trading privileges. After a century of expansion on the coasts of Africa and the Indian Ocean, the Portuguese had grown accustomed to the model of the factory (feitoria), in both those places in which the Portuguese governed in their own name and those in which they traded at the sufferance of African and Asian rulers. On the other hand, over the course of the sixteenth and seventeenth centuries, the Ottomans had granted so-called capitulations to European powers in the Mediterranean, which were governed by norms that were distinct from the factory model of Africa and Asia. Basra brought these two models into interaction and disrupted the straightforward implementation of either model. Frequent moments of misunderstanding and manoeuvring between the two sides were the result.

The epithelial-to-mesenchymal transition (EMT) and the unjamming transition (UJT) each comprises a gateway to cellular migration, plasticity and remodeling, but the extent to which these core programs are distinct, overlapping, or identical has remained undefined. Here, we triggered partial EMT (pEMT) or UJT in differentiated primary human bronchial epithelial cells. After triggering UJT, cell-cell junctions, apico-basal polarity, and barrier function remain intact, cells elongate and align into cooperative migratory packs, and mesenchymal markers of EMT remain unapparent. After triggering pEMT these and other metrics of UJT versus pEMT diverge. A computational model attributes effects of pEMT mainly to diminished junctional tension but attributes those of UJT mainly to augmented cellular propulsion. Through the actions of UJT and pEMT working independently, sequentially, or interactively, those tissues that are subject to development, injury, or disease become endowed with rich mechanisms for cellular migration, plasticity, self-repair, and regeneration. During repair, development, or cancer metastasis, epithelial cells can become migratory through partial or full epithelial to mesenchymal transition (EMT). Here, the authors report that differentiated epithelial collectives may undergo cooperative and collective migration without evidence of partial EMT through an unjamming transition (UJT).

Legume seed protein is an important source of nutrition, but generally it is less digestible than animal protein. Poor protein digestibility in legume seeds and seedlings may partly reflect defenses against herbivores. Protein changes during germination typically increase proteolysis and digestibility, by lowering the levels of anti-nutrient protease inhibitors, activating proteases, and breaking down storage proteins (including allergens). Germinating legume sprouts also show striking increases in free amino acids (especially asparagine), but their roles in host defense or other processes are not known. While the net effect of germination is generally to increase the digestibility of legume seed proteins, the extent of improvement in digestibility is species- and strain-dependent. Further research is needed to highlight which changes contribute most to improved digestibility of sprouted seeds. Such knowledge could guide the selection of varieties that are more digestible and also guide the development of food preparations that are more digestible, potentially combining germination with other factors altering digestibility, such as heating and fermentation. Techniques to characterize the shifts in protein make-up, activity and degradation during germination need to draw on traditional analytical approaches, complemented by proteomic and peptidomic analysis of mass spectrometry-identified peptide breakdown products.

This essay makes a case for studying spirituality through the lens of the spirit of authenticity in human subjectivity. It does so in the context of the need today to give greater priority to reaching out to spiritual seekers who are not at home with Christian spirituality and who would be put off, therefore, by approaches of an explicitly Christian kind. Authentic subjectivity, however, also provides the basis for the Christian spirituality scholar-practitioner to draw on explicit Christian resources, when it serves their context, interlocutors, and more-than-human world.

•Visual working memory recruits a frontoparietal-inferotemporal network during delay.•Sustained delay-period activity is not evident in early visual cortex.•Patterns of delay activity depend on different aspects of visual working memory. Visual working memory refers to the temporary maintenance and manipulation of task-related visual information. Recent debate on the underlying neural substrates of visual working memory has focused on the delay period of relevant tasks. Persistent neural activity throughout the delay period has been recognized as a correlate of working memory, yet regions demonstrating sustained hemodynamic responses show inconsistency across individual studies. To develop a more precise understanding of delay-period activations during visual working memory, we conducted a coordinate-based meta-analysis on 30 fMRI experiments involving 515 healthy adults with a mean age of 25.65 years. The main analysis revealed a widespread frontoparietal network associated with delay-period activity, as well as activation in the right inferior temporal cortex. These findings were replicated using different meta-analytical algorithms and were shown to be robust against between-study heterogeneity and publication bias. Further meta-analyses on different subgroups of experiments with specific task demands and stimulus types revealed similar delay-period networks, with activations distributed across the frontal and parietal cortices. The roles of prefrontal regions, posterior parietal regions, and inferior temporal areas are reviewed and discussed in the context of content-specific storage. We conclude that cognitive operations that occur during the unfilled delay period in visual working memory tasks can be flexibly expressed across a frontoparietal-temporal network depending on experimental parameters.

Abstract Childhood-onset schizophrenia (COS) is a rare and severe form of schizophrenia with an estimated prevalence of 1/10,000. Schizophrenia and Autism spectrum disorder (ASD) have shared phenotypic features and shared genetic etiology. There is growing research surrounding the co-occurrence of psychomotor syndromes like catatonia with neurodevelopmental disorders like ASD or psychiatric disorders like schizophrenia. In 2013, Shorter and Wachtel described a phenomenon of the ‘Iron Triangle’ where COS, ASD, and catatonia often co-occur. The Iron Triangle theory is based on observation of historical case literature, which showed that all three diagnoses in the Iron Triangle were routinely assigned to children and adolescents. The pattern of this “Iron Triangle” suggests there may be a single underlying pathology resulting in a unique mixed form of catatonia, autism, and psychosis. We describe the case of a boy with sequential development of COS, ASD, and catatonia who also has syndromic facial and musculoskeletal features. This case highlights overlapping diagnostic features of these three disorders and can help us better understand how “hidden” features of catatonia may occur in patients with COS or ASD but go unrecognized, because they are grouped as features under autism/schizophrenia rather than a distinct diagnosis of catatonia. Further study is warranted to elucidate if this phenotypic pattern constitutes a new single diagnosis that is not well understood, an endophenotype of schizophrenia, or if this is the result of phenomenological overlap between catatonia, ASD, and COS.

Despite the importance of grains and legumes in the human diet, little is known regarding peptide release and the temporal changes of protease activities during seed germination. LC/MS-MS peptidomic analysis of two cultivars of germinating chickpea followed by computational analyses indicated cleavage dominated by proteases with a single position preference (mainly before (P1) or after cleavage (P1’): L at P2 (cysEP-like); R or K at P1 (vignain-like), N or Q at P1 (legumain-like); and previously unidentified K, R, A and S at P1’; A at P2’). While P1 N cleavages were relatively constant, P1’ K/R preferences were high in soaked garbanzo (kabuli) seeds, declined by four days, and returned at six days, but were much rarer in the brown (desi) cultivar. Late Embryogenesis Associated (LEA) peptides were markedly released during early germination. Vicilin peptides rich in glutamic acid near their N-termini markedly increased with germination, consistent with strong proteolytic resistance, even to human digestion, as indicated by analyses of separate datasets. Thus, this first peptidomics study of seed germination proteolytic profiles unveils a complex cultivar-specific programme of sequential activation and inactivation of a series of proteases, associated with the differential release of peptides from different protein groups.