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A 12‐year‐old, neutered female, domestic medium hair cat was evaluated for a nonhealing, oral mucosal ulceration. The cat had a history of idiopathic hypercalcemia that had been treated with a bisphosphonate for 41 months. Oral examination identified exposed maxillary bone adjacent to a previous extraction site. Histopathology of the exposed bone and associated mucosa was most consistent with medication‐related osteonecrosis of the jaw. Treatment involved both medical and surgical interventions. Oral mucosal healing occurred after 6 months of treatment.

Encouraging vaccination is a pressing policy problem. To assess whether text-based reminders can encourage pharmacy vaccination and what kinds of messages work best, we conducted a megastudy. We randomly assigned 689,693 Walmart pharmacy patients to receive one of 22 different text reminders using a variety of different behavioral science principles to nudge flu vaccination or to a business-as-usual control condition that received no messages. We found that the reminder texts that we tested increased pharmacy vaccination rates by an average of 2.0 percentage points, or 6.8%, over a 3-mo follow-up period. The most-effective messages reminded patients that a flu shot was waiting for them and delivered reminders on multiple days. The top-performing intervention included two texts delivered 3 d apart and communicated to patients that a vaccine was “waiting for you.” Neither experts nor lay people anticipated that this would be the best-performing treatment, underscoring the value of simultaneously testing many different nudges in a highly powered megastudy

Background: Folate metabolism pathway genes have been examined for association with neural tube defects (NTDs) because folic acid supplementation reduces the risk of this debilitating birth defect. Most studies addressed these genes individually, often with different populations providing conflicting results. Objectives: Our study evaluates several folate pathway genes for association with human NTDs, incorporating an environmental cofactor: maternal folate supplementation. Methods: In 304 Caucasian American NTD families with myelomeningocele or anencephaly, we examined 28 polymorphisms in 11 genes: folate receptor 1, folate receptor 2, solute carrier family 19 member 1, transcobalamin II, methylenetetrahydrofolate dehydrogenase 1, serine hydroxymethyltransferase 1, 5,10-methylenetetrahydrofolate reductase (MTHFR), 5-methyltetrahydrofolate-homocysteine methyltransferase, 5-methyltetrahydrofolate-homocysteine methyltransferase reductase, betaine-homocysteine methyltransferase (BHMT), and cystathionine-beta-synthase. Results: Only single nucleotide polymorphisms (SNPs) in BHMT were significantly associated in the overall data set; this significance was strongest when mothers took folate-containing nutritional supplements before conception. The BHMT SNP rs3733890 was more significant when the data were stratified by preferential transmission of the MTHFR rs1801133 thermolabile T allele from parent to offspring. Other SNPs in folate pathway genes were marginally significant in some analyses when stratified by maternal supplementation, MTHFR, or BHMT allele transmission. Conclusions: BHMT rs3733890 is significantly associated in our data set, whereas MTHFR rs 1801133 is not a major risk factor. Further investigation of folate and methionine cycle genes will require extensive SNP genotyping and/or resequencing to identify novel variants, inclusion of environmental factors, and investigation of gene-gene interactions in large data sets.

Combining Atacama Large Millimeter/sub-millimeter Array CO(2-1) mapping and JWST near- and mid-infrared imaging, we characterize the relationship between CO(2-1) and polycyclic aromatic hydrocarbon (PAH) emission at ~100 pc resolution in 66 nearby star-forming galaxies, expanding the sample size from previous ~100 pc resolution studies by more than an order of magnitude. Focusing on regions of galaxies where most of the gas is likely to be molecular, we find strong correlations between CO(2-1) and 3.3 micron, 7.7 micron, and 11.3 micron PAH emission, estimated from JWST's F335M, F770W, and F1130W filters. We derive power law relations between CO(2-1) and PAH emission, which have indices in the range 0.8-1.2, implying relatively weak variations in the observed CO-to-PAH ratios across the regions that we study. We find that CO-to-PAH ratios and scaling relationships near HII regions are similar to those in diffuse sight lines. The main difference between the two types of regions is that sight lines near HII regions show higher intensities in all tracers. Galaxy centers, on the other hand, show higher overall intensities and enhanced CO-to-PAH ratios compared to galaxy disks. Individual galaxies show 0.19 dex scatter in the normalization of CO at fixed I_PAH and this normalization anti-correlates with specific star formation rate (SFR/M*) and correlates with stellar mass. We provide a prescription that accounts for these galaxy-to-galaxy variations and represents our best current empirical predictor to estimate CO(2-1) intensity from PAH emission, which allows one to take advantage of JWST's excellent sensitivity and resolution to trace cold gas.