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The aim of this study was to ascertain whether there has been an increase in the number of workers with long-term sickness absence due to mental disorders (LTSA-MD) and determine the impact of remote work on new LTSA-MD cases. A web-based questionnaire was sent to 2,552 company offices with 150 or more workers in Osaka Prefecture. Data were obtained on the number of workers with LTSA-MD between April 1, 2019, and March 31, 2020 (fiscal year 2019) and between April 1, 2020, and March 31, 2021 (fiscal year 2020), along with their MD diagnoses (adjustment disorder [AD], depressive disorder [DEP], etc.). The difference in the number of new LTSA-MD, LTSA-AD, and LTSA-DEP cases between the fiscal years was evaluated, as well as the number of LTSA-MD cases per 100 employees. An independent t-test was used to compare the groups. DEP was the most prevalent condition, followed by AD. The number of workers with LTSA-MD nominally decreased from fiscal 2019 to fiscal year 2020, with no significant difference. There were no significant differences between fiscal year 2020 and fiscal year 2019 regarding LTSA-MD, LTSA-AD, and LTSA-DEP in offices with and without a remote work model. The number of non-public workers with LTSA-MD did not increase during the COVID-19 pandemic, with no significant difference observed between offices with and without a remote work model. This provides preliminary evidence of a potential protective effect of remote work against LTSA-DEP.

This study aims to clarify the effect of occupational stress and changes in the work environment on non-healthcare workers’ (HCWs) mental health during the third wave of the COVID-19 pandemic in Japan. A web-based, cross-sectional survey was conducted from 16 to 17 December 2020. Data from 807 non-HCWs were included. We evaluated occupational stress using the Generic Job Stress Questionnaire (GJSQ). Depressive and anxiety symptoms were assessed using the Japanese version of the Patient Health Questionnaire-9 and the Generalized Anxiety Disorder 7-item scale, respectively. We collected demographic variables, work-related variables, and the variables associated with COVID-19. The adjusted odds ratios for depressive and anxiety groups were estimated using multivariate logistic regression analyses, adjusted for all the demographic variables, work-related variables, COVID-19-related variables, and the six subdivided GJSQ subscales. The results confirm a relationship between variance in workload, job future ambiguity, social support from coworkers, having contact with COVID-19 patients, and depressive and anxiety symptoms. Paying attention to job future ambiguity, the variance in workload at the workplace and individual perspectives, promoting contact and support among coworkers using online communication tools, and reducing contact with COVID-19 patients, will be useful for decreasing the depressive and anxiety symptoms among non-HCWs.

The coronavirus disease 2019 (COVID‐19) pandemic and government regulations have affected the daily lives and mental health of individuals worldwide. This study aimed to determine how much the change in time spent on exercise (exercise time), outdoor activities (“going‐out” time), and screen usage (screen time) before and after the COVID‐19 pandemic has affected mental health (depression, anxiety, and insomnia). In June 2021, during the third wave of the COVID‐19 pandemic, a web‐based, cross‐sectional survey was conducted in Japan through an online research company. A total of 824 workers participated in this study. Depression, anxiety, and insomnia were assessed using the Patient Health Questionnaire‐9, General Anxiety Disorder‐7, and Insomnia Severity Index, respectively. The symptoms of depression were associated with age and decreased exercise time. Symptoms of anxiety were associated with not decreased going‐out time. Symptoms of insomnia were associated with reduced exercise time. The results indicated that during the COVID‐19 pandemic, an increase in exercise time could have prevented depression and insomnia. Similarly, a decrease in going‐out time could have prevented anxiety. Furthermore, in the event of future outbreaks of unpredictable infections, such as COVID‐19, decreased going out and increased exercise may help maintain mental health. The study of 824 Japanese workers found reduced exercise tied to depression and insomnia during the COVID‐19 pandemic. Maintained outdoor activity was linked to anxiety. It suggests more exercise and less outdoor time can improve mental health in future pandemics.

The nanoparticle layer detachment during nucleate pool boiling and its influences on heat transfer surface properties were explored experimentally. The material of the heat transfer surface was copper and the nanoparticle layer was formed on the heat transfer surface by nucleate boiling in the water-based TiO 2 nanofluid. It was found that the detachment of the nanoparticle layer during nucleate boiling in pure water is significant. In the present experiment, more than half of nanoparticles deposited on the heated surface were detached before the CHF condition was reached. The thickness and roughness decreased accordingly. However, the wettability and wickability that are the influential parameters on the CHF value were maintained even after the occurrence of nanoparticle layer detachment and deteriorated only after the CHF condition was reached. It is therefore considered that the onset of CHF brings qualitative change to the capillary suction performance of the layer of nanoparticles. In exploring the effect of the nanoparticle layer properties on the nucleate boiling heat transfer, sufficient attention should be paid to the variation of the nanoparticle layer properties during nucleate boiling.

ABSTRACT TMEM41B and VMP1 are endoplasmic reticulum (ER)-localizing multi-spanning membrane proteins required for ER-related cellular processes such as autophagosome formation, lipid droplet homeostasis, and lipoprotein secretion in eukaryotes. Both proteins have a VTT domain, which is similar to the DedA domain found in bacterial DedA family proteins. However, the molecular function and structure of the DedA and VTT domains (collectively referred to as DedA domains) and the evolutionary relationships among the DedA domain-containing proteins are largely unknown. Here, we conduct remote homology search and identify a new clade consisting mainly of bacterial PF06695 proteins of unknown function. Phylogenetic analysis reveals that the TMEM41, VMP1, DedA, and PF06695 families form a superfamily with a common origin, which we term the DedA superfamily. Coevolution-based structural prediction suggests that the DedA domain contains two reentrant loops that face each other in the membrane. This topology is biochemically verified by the substituted cysteine accessibility method. The predicted structure is topologically similar to that of the substrate-binding region of Na+-coupled glutamate transporter solute carrier 1. A potential ion-coupled transport function of the DedA superfamily proteins is discussed. Competing Interest Statement The authors have declared no competing interest.