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"Olsen, A."
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Burden of Clostridium difficile on the Healthcare System
There are few high-quality studies of the costs of Clostridium difficile infection (CDI), and the majority of studies focus on the costs of CDI in acute-care facilities. Analysis of the best available data, from 2008, indicates that CDI may have resulted in $4.8 billion in excess costs in US acute-care facilities. Other areas of CDI-attributable excess costs that need to be investigated are costs of increased discharges to long-term care facilities, of CDI with onset in long-term care facilities, of recurrent CDI, and of additional adverse events caused by CDI.
Journal Article
World flutelore : folktales, myths, and other stories of magical flute power
In many places around the world, flutes and the sounds of flutes are powerful magical forces for seduction and love, protection, vegetal and human fertility, birth and death, and other aspects of human and non-human behaviour. This book explores the cultural significance of flutes, flute playing, and flute players from around the world as interpreted from folktales, myths, and other stories - in a word, 'flutelore'.
Book
The Recent LMC–SMC Collision: Timing and Impact Parameter Constraints from Comparison of Gaia LMC Disk Kinematics and N-body Simulations
We present analysis of the proper-motion (PM) field of the red clump stars in the Large Magellanic Cloud (LMC) disk using the Gaia Early Data Release 3 catalog. Using a kinematic model based on old stars with 3D velocity measurements, we construct the residual PM field by subtracting the center-of-mass motion and internal rotation motion components. The residual PM field reveals asymmetric patterns, including larger residual PMs in the southern disk. Comparisons of the observed residual PM field with those of five numerical simulations of an LMC analog that is subject to the tidal fields of the Milky Way and the Small Magellanic Cloud (SMC) show that the present-day LMC is not in dynamical equilibrium. We find that both the observed level of disk heating (PM residual rms of 0.057 ± 0.002 mas yr−1) and kinematic asymmetry are not reproduced by Milky Way tides or if the SMC impact parameter is larger than the size of the LMC disk. This measured level of disk heating provides a novel and important method to validate numerical simulations of the LMC–SMC interaction history. Our results alone put constraints on an impact parameter ≲10 kpc and impact timing <250 Myr. When adopting the impact timing constraint of ∼140–160 Myr ago from previous studies, our results suggest that the most recent SMC encounter must have occurred with an impact parameter of ∼5 kpc. We also find consistent radial trends in the kinematically and geometrically derived disk inclination and line-of-node position angles, indicating a common origin.
Journal Article
Precise Measurements of the LMC Bar’s Geometry with Gaia DR3 and a Novel Solution to Crowding-induced Incompleteness in Star Counting
We present new measurements of the 2D geometry of the LMC’s stellar bar with precise astrometric observations of red clump stars in Gaia DR3. We develop a novel solution to tackle crowding-induced incompleteness in Gaia data sets with the Gaia BP-RP color excess. Utilizing the color excess information, we derive a 2D completeness map of the LMC’s disk. We find that incompleteness biases the bar measurements and induces large uncertainties. With the completeness-corrected 2D red clump map, we precisely measure the LMC bar’s properties using Fourier decomposition. The bar radius (semimajor axis) is Rbar=2.13−0.04+0.03 kpc, and its position angle is 121.°26 ± 0.°21. The bar’s strength as quantified by the Fourier bi-symmetric amplitude is S bar = 0.27, indicating that the LMC has a significant bar perturbation. We find the bar has an axis ratio of 0.54 ± 0.03, and is offset with respect to the center of the outer disk isophote at R ≈ 5 kpc by 0.76 ± 0.01 kpc. These LMC bar properties agree with a hydrodynamic model where the SMC has undergone a recent direct collision with the LMC. We compare the LMC’s bar properties with other barred galaxies in the local Universe, and discover that the LMC is similar to other barred galaxies in terms of bar-galaxy scaling relations. We discuss how our completeness correction framework can be applied to other systems in the Local Group.
Journal Article
Metabolic syndrome, metabolic comorbid conditions and risk of early-onset colorectal cancer
ObjectiveFactors that lead to metabolic dysregulation are associated with increased risk of early-onset colorectal cancer (CRC diagnosed under age 50). However, the association between metabolic syndrome (MetS) and early-onset CRC remains unexamined.DesignWe conducted a nested case–control study among participants aged 18–64 in the IBM MarketScan Commercial Database (2006–2015). Incident CRC was identified using pathologist-coded International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) codes, and controls were frequency matched. MetS was defined as presence of ≥3 conditions among obesity, hypertension, hyperlipidaemia and hyperglycaemia/type 2 diabetes, based on ICD-9-CM and use of medications. Multivariable logistic regressions were used to estimate ORs and 95% CIs.ResultsMetS was associated with increased risk of early-onset CRC (n=4673; multivariable adjusted OR 1.25; 95% CI 1.09 to 1.43), similar to CRC diagnosed at age 50–64 (n=14 928; OR 1.21; 95% CI 1.15 to 1.27). Compared with individuals without a metabolic comorbid condition, those with 1, 2 or ≥3 conditions had a 9% (1.09; 95% CI 1.00 to 1.17), 12% (1.12; 95% CI 1.01 to 1.24) and 31% (1.31; 95% CI 1.13 to 1.51) higher risk of early-onset CRC (ptrend <0.001). No associations were observed for one or two metabolic comorbid conditions and CRC diagnosed at age 50–64. These positive associations were driven by proximal (OR per condition 1.14; 95% CI 1.06 to 1.23) and distal colon cancer (OR 1.09; 95% CI 1.00 to 1.18), but not rectal cancer (OR 1.03; 95% CI 0.97 to 1.09).ConclusionsMetabolic dysregulation was associated with increased risk of early-onset CRC, driven by proximal and distal colon cancer, thus at least in part contribute to the rising incidence of early-onset CRC.
Journal Article
Who donates in campaigns? : the importance of message, messenger, medium, and structure
\"Campaigns cost money--a lot of money. In 2012, Mitt Romney, Barack Obama, and their allies collectively spent more than $2 billion in the race for the presidency, with both sides spending more than $1 billion. Looking just at money raised by the campaigns from individual donors, the Obama campaign outraised the Republicans by over $500 million in 2008 and over $250 million in 2012.1\"-- Provided by publisher.
Book
Trends in Global Tropospheric Ozone Inferred from a Composite Record of TOMS/OMI/MLS/OMPS Satellite Measurements and the MERRA-2 GMI Simulation
Past studies have suggested that ozone in the troposphere has increased globally throughout much of the 20th century due to increases in anthropogenic emissions and transport. We show, by combining satellite measurements with a chemical transport model, that during the last four decades tropospheric ozone does indeed indicate increases that are global in nature, yet still highly regional. Satellite ozone measurements from Nimbus-7 and Earth Probe Total Ozone Mapping Spectrometer (TOMS) are merged with ozone measurements from the Aura Ozone Monitoring Instrument/Microwave Limb Sounder (OMI/MLS) to determine trends in tropospheric ozone for 1979–2016. Both TOMS (1979–2005) and OMI/MLS (2005–2016) depict large increases in tropospheric ozone from the Near East to India and East Asia and further eastward over the Pacific Ocean. The 38-year merged satellite record shows total net change over this region of about +6 to +7 Dobson units (DU) (i.e., ∼15 %–20 % of average background ozone), with the largest increase (∼4 DU) occurring during the 2005–2016 Aura period. The Global Modeling Initiative (GMI) chemical transport model with time-varying emissions is used to aid in the interpretation of tropospheric ozone trends for 1980–2016. The GMI simulation for the combined record also depicts the greatest increases of +6 to +7 DU over India and East Asia, very similar to the satellite measurements. In regions of significant increases in tropospheric column ozone (TCO) the trends are a factor of 2–2.5 larger for the Aura record when compared to the earlier TOMS record; for India and East Asia the trends in TCO for both GMI and satellite measurements are ∼+3 DU decade(exp −1) or greater during 2005–2016 compared to about +1.2 to +1.4 DU decade(exp −1) for 1979–2005. The GMI simulation and satellite data also reveal a tropospheric ozone increases in ∼+4 to +5 DU for the 38-year record over central Africa and the tropical Atlantic Ocean. Both the GMI simulation and satellite-measured tropospheric ozone during the latter Aura time period show increases of ∼+3 DU decade−1 over the N Atlantic and NE Pacific.
Journal Article