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In recent years, researchers have often encountered the significance of the aberrant metabolism of tumor cells in the pathogenesis of malignant neoplasms. This phenomenon, known as the Warburg effect, provides a number of advantages in the survival of neoplastic cells, and its application is considered a potential strategy in the search for antitumor agents. With the aim of developing a promising platform for designing antitumor therapeutics, we synthesized a library of conjugates of 3,5-bis(arylidene)-4-piperidone and sesquiterpene lactones. To gain insight into the determinants of the biological activity of the prepared compounds, we showed that the conjugates of 3,5-bis(arylidene)-4-piperidone and sesquiterpene lactones, which are cytotoxic agents, demonstrate selective activity toward a number of tumor cell lines with glycolysis-inhibiting ability. Moreover, the results of molecular and in silico screening allowed us to identify these compounds as potential inhibitors of the pyruvate kinase M2 oncoprotein, which is the rate-determining enzyme of glycolysis. Thus, the results of our work indicate that the synthesized conjugates of 3,5-bis(arylidene)-4-piperidone and sesquiterpene lactones can be considered a promising platform for designing selective cytotoxic agents against the glycolysis process, which opens new possibilities for researchers involved in the search for antitumor therapeutics among compounds containing piperidone platforms.

In the construction materials industry, expensive refractories (fire clay, silica, high-aluminous, etc.), are used as the main lining materials which despite their high fire resistance are inefficient for the use in thermal aggregates with an operation temperature up to 1300 °C. The purpose of the research was to develop heat-resistant concrete on the basis of sodium silicate binder and liquid glass with application of ferrochrome slag. Studies on the use of ferrochrome slag to obtain heat-resistant concrete are quite limited. It is common to apply self-scattered ferrochrome slag as a hardener when liquid glass is used. Carbonaceous ferrochrome slag is used when getting sodium silicate binder and as a filler together with other fire-resistant materials. Therefore, development of low-component heat-resistant concrete, which contains in the binder and filler the same raw materials with uniform-phase structure, represents a certain scientific and practical interest. On the basis of carbonaceous ferrochrome slag, sodium silicate binder and heat-resistant concrete with uniform-phase structure have been developed. Also a heat-resistant concrete mix has been developed with an application of liquid glass and without any special hardener. Curing of concrete on sodium silicate binder was carried out by drying in the range of temperatures of 100-200 °C, curing of concrete on liquid glass was done with drying in the range of temperatures of 105±5 °C. Compression strength of concrete on sodium silicate binder after drying was 26.2 MPa, compression strength of concrete on liquid glass was 25.8 MPa.

The use of metallothermy (MT) and self-propagating high-temperature synthesis (SHS) is considered for processing different geological and technogenic materials. Traditional MT and SHS processes for production of various metals and nonmetal materials are widely known. Another rapidly developing direction is that connected with the use of ores, concentrates, minerals, and technogenic waste products as one of the components of a thermite mixture, both for the treatment of mineral raw by means of MT or SHS resulting in semi-products and for technological, analytical, and ecological purposes.