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Coronavirus disease 2019 is a new respiratory disease that spreads rapidly caused severe acute respiratory syndrome coronavirus-2 where the severity of symptoms varies from person to person according to different factors, including blood group type. In this study, we investigate the effect of different blood groups type (A, B, AB, and O) on the different severity of clinical outcomes in COVID-19 patients and the risk of SARS-CoV-2 infection. with 100 patients from The initial monitoring and rapid response center for the Corona epidemic- Al-Bayda, were confirmed covid-19 positive by RT-PCR, the different clinical symptoms and blood groups type were questioned and investigated and we have used Analytic to statistics SPSS T.test, we absorption a relationship between the severity of symptoms with the different blood group A, B, AB, and O 48%, 13%, 3%, and 37%, respectively.