Explore the vast range of titles available.

The current work sets out to design and develop a carbamazepine (CBZ) extended-release tablet in the treatment of epilepsy using wet granulation technology. The tablets were prepared using HPMC K 100M and ethyl cellulose as hydrophilic and hydrophobic polymers, respectively. The effect of the concentration of the polymer was studied. The studies indicated that the drug release can be modulated by varying the concentration of the polymer. Tapped density, bulk density, angle of repose, Hausner's ratio, and Carr's index were all calculated for powder blends. The prepared trial batches of tablets were first characterized for hardness, friability, weight variation, and drug content to select an optimized batch. An in-vitro dissolution study of the optimized batch (F4) was carried out in distilled water using a USP Type I (basket type) dissolution apparatus at 100rpm. The optimized formulation (F4) showed a drug content of 99.51%. In-vitro drug release of optimized formulation was found to be 88.10% in 24hours. The optimised formulation demonstrated release for up to 24 hours. The optimised formulation's stability was studied for three months at 40±2ºC/75±5% RH, 30±2ºC/65±5% RH, and 25±2ºC/60±5% RH, and the prepared tablets showed no remarkable effect from the stability study. The results suggest that the developed extended-release tablets of CBZ (400 mg) could perform as therapeutically equivalent alternatives to conventional dosage forms, leading to better patient compliance.

Quantum-mechanically indistinguishable photons produced by independent (or equivalently, mutually phase incoherent) light sources are essential for distributed quantum information processing applications. We demonstrate heralded generation of such photons in two spatially separate telecom-fiber spools, each driven by pulsed pump waves that are measured to have no mutual phase coherence. Through Hong-Ou-Mandel experiments, we measure the quantum interference visibility of those photons to be . Our experimental results are well predicted by a quantum multimode theory we developed for such systems without the need for any fitting parameter.

Modal analysis is extensively used to identify the dynamic properties of a structure in terms of the dynamic characteristics: natural frequency, damping factor and mode shape. In this research, modal analysis has been carried out on a radial flow impeller of a centrifugal pump. The 3-D model of the impeller was built in CAD software Creo Parametric 1.0 from a 2-D drawing and that model was imported in FEA software package ANSYS for conducting modal analysis. The model was meshed effectively using SOLID187 elements. The first twenty natural frequency and mode shapes were extracted and nodal diameter was identified for each mode shape. The experimental modal analysis was conducted using impact hammer and the first twenty natural frequencies were identified using FFT analyzer. The natural frequencies of both the methods were compared and it was found that there is a good agreement between these results, thus the FE model is validated. The results are discussed and conclusions drawn.

Saliva is one of the most abundant secretions in the human body and its collection is easy and noninvasive. The aim of this study was to find a medium that can be used to diagnose and monitor diabetes. In this, saliva could play a major role. To substantiate the role of saliva as a diagnostic tool, we compared saliva samples with blood glucose and glycated hemoglobin (HbA(1c)) in healthy and diabetic subjects. Included in the study were 106 patients, newly diagnosed with type 2 diabetes mellitus and 15 healthy control subjects. The patients and control subjects were asked to come to the clinic in the morning, after an 8-hour fast. At that time, 5 mL of venous blood was collected, 2 mL of which was collected in an ethylenediaminetetraacetic acid (EDTA)-containing blood collection tube and sent for HbA(1c) estimation. Unstimulated saliva was collected from both groups as well. The saliva and sera from the blood samples were subjected to glucose estimation. The correlation coefficient between serum glucose and salivary glucose in the control group was calculated and the r value was found to be 0.5216, which was statistically significant (P < 0.05). The correlation coefficient between serum glucose and salivary glucose in the patient group was also calculated and the r value was found to be 0.7686, which was highly significant (P < 0.01). Finally, the correlation coefficient between HbA(1c) level and salivary glucose in the patient group was calculated and the r value was found to be 0.5662, which was also highly significant (P < 0.01).

Today, in the era of minimally invasive surgery, paediatric laparoscopy has become widely popular. Extra-adrenal pheochromocytoma is a very rare entity, especially in the paediatric age group and utility of the laparoscopic approach is not established in this population. Early diagnosis and surgical excision are integral part of treatment of childhood pheochromocytoma. We present a case study of a child with hormonally active extra-adrenal pheochromocytoma that was resected laparoscopically. Laparoscopic approach provides excellent exposure with magnification and allows proper identification of the tumour and its relation to surrounding structures; complete resection of tumour was achieved with adequate vascular control. With our initial experience, we suggest laparoscopic resection is an appropriate and feasible tool in such cases.

Although the structural gene for diphtheria toxin, tox, is carried by a family of closely related corynebacteriophages, the regulation of tox expression is controlled, to a large extent, by its bacterial host Corynebacterium diphtheriae. Optimal yields of tox gene products are obtained only when iron becomes the growth-rate-limiting substrate. Previous studies suggest that regulation of tox expression is mediated through an iron-binding aporepressor. To facilitate molecular cloning of the tox regulatory element from genomic libraries of C. diphtheriae, we constructed a tox promoter/operator (toxPO)-lacZ transcriptional fusion in Escherichia coli strain DH5α. We report the molecular cloning and nucleic acid sequence of a diphtheria tox iron-dependent regulatory element, dtxR, and demonstrate that expression of β-galactosidase from the toxPO-lacZ fusion is regulated by dtxR-encoded protein in an iron-sensitive manner. In addition, we show that expression of the toxPO-lacZ fusion is not affected by the E. coli iron-regulatory protein Fur and that the dtxR protein does not inhibit expression of fur-regulated outer-membrane proteins.

SBND is the near detector of the Short-Baseline Neutrino program at Fermilab. Its location near to the Booster Neutrino Beam source and relatively large mass will allow the study of neutrino interactions on argon with unprecedented statistics. This paper describes the expected performance of the SBND photon detection system, using a simulated sample of beam neutrinos and cosmogenic particles. Its design is a dual readout concept combining a system of 120 photomultiplier tubes, used for triggering, with a system of 192 X-ARAPUCA devices, located behind the anode wire planes. Furthermore, covering the cathode plane with highly-reflective panels coated with a wavelength-shifting compound recovers part of the light emitted towards the cathode, where no optical detectors exist. We show how this new design provides a high light yield and a more uniform detection efficiency, an excellent timing resolution and an independent 3D-position reconstruction using only the scintillation light. Finally, the whole reconstruction chain is applied to recover the temporal structure of the beam spill, which is resolved with a resolution on the order of nanoseconds.

A significant challenge in measurements of neutrino oscillations is reconstructing the incoming neutrino energies. While modern fully-active tracking calorimeters such as liquid argon time projection chambers in principle allow the measurement of all final state particles above some detection threshold, undetected neutrons remain a considerable source of missing energy with little to no data constraining their production rates and kinematics. We present the first demonstration of tagging neutrino-induced neutrons in liquid argon time projection chambers using secondary protons emitted from neutron-argon interactions in the MicroBooNE detector. We describe the method developed to identify neutrino-induced neutrons and demonstrate its performance using neutrons produced in muon-neutrino charged current interactions. The method is validated using a small subset of MicroBooNE’s total dataset. The selection yields a sample with 60 % of selected tracks corresponding to neutron-induced secondary protons. At this purity, the integrated efficiency is 8.4% for neutrons that produce a detectable proton.

This paper examines the contribution of faculty members of the universities in Gujarat particularly in the areas of Physics and multidisciplinary. For the study data collected from web of science for the period of span under the study. Various search strategies were applied to collect the data and Scientometric techniques used to achieve research objectives. The study found cited items, citing articles, h- index of universities and faculties in the subject area. The study further recommended for the establishment of citation database for the publication in Indian languages to provide such platform for scholarly communication in Indian languages to keep a pace with the latest research trends.

The Short-Baseline Near Detector (SBND), the near detector in the Short-Baseline Neutrino Program at Fermi National Accelerator Laboratory, is located just 110 m from the Booster Neutrino Beam target. Thanks to this close proximity, relative to its 4 m \\(\\) 4 m front face, neutrinos enter SBND over a range of angles from \\(0^\\) to approximately \\(1.6^\\), enabling the detector to sample variations in the neutrino flux as a function of angle-a technique known as PRISM, referred to here as SBND-PRISM. In this paper, we show how muon- and electron-neutrino fluxes vary as a function of the neutrino beam axis angle and how this can be exploited to expand the physics potential of SBND. We make use of a model that predicts an angle-dependent electron-neutrino excess signal to illustrate this effect, such as \\(_ _e\\) oscillations. We present how SBND-PRISM provides a method to add robustness against uncertainties in cross-section modeling and, more generally, uncertainties that do not depend on the spatial position of neutrino interaction inside the detector. The fluxes, along with their associated covariance matrices, are made publicly available with this publication.