Explore the vast range of titles available.

Background Huntington’s disease (HD) is a progressive neurodegenerative disease, characterised by motor disturbances and non-motor (i.e., psychiatric) symptoms. Motor symptoms are the hallmark features of HD and take many forms. Their emergence is related to alterations in striatal dopaminergic neurotransmission: dopamine levels increase in the early stages of the disease, while more advanced stages are characterised by reduced dopamine levels. Such a biphasic change potentially explains the alterations in motor symptoms: increased dopamine-production induces hyperkinetic movements early in the disease course, while depleted dopamine storage leads to hypokinetic symptoms in the advanced phase. Dopamine D2-D3 partial agonists could be a promising treatment option in HD, as they have the potential to either elevate or lower the surrounding dopamine levels if the levels are too low or too high, respectively, potentially offering symptom-relief across the illness-course. Therefore, the present study aimed at exploring the effects of cariprazine, a dopamine D2-D3 partial agonist with high affinity to D3 receptors, on motor symptoms associated with HD. Methods This was a single-centre, retrospective study where sixteen patients received off-label cariprazine treatment for 12 weeks (1.5-3 mg/day). Motor symptoms were evaluated using the Motor Assessment of the Unified Huntington’s Disease Rating Scale. Least Square (LS) Mean Changes from Baseline (BL) to Week 8 and Week 12 in the Total Motor Score (TMS) were analysed using the Mixed Model for Repeated Measures method. In addition, improvement from BL to Week 8 and 12 was calculated for all motor items. Results Data of 16 patients were collected, but data of only 15 patients were analysed as one patient dropped out due to non-compliance. Significant changes were observed from BL to Week 8 (LS Mean Change: -9.4, p < 0.0001) and to Week 12 (LS Mean Change: -12.8, p < 0.0001) in the TMS. The improvement was captured in the majority of motor functions, excluding bradykinesia and gait. Mild akathisia was the most commonly reported side-effect, affecting 3 patients. Conclusion This is the first study investigating the effectiveness of a D2-D3 partial agonist, cariprazine, in the treatment of HD. The findings of this study revealed that cariprazine was effective in the treatment of a wide range of motor symptoms associated with HD.

Schizophrenia is a chronic and severe mental disorder characterized by positive, negative, and cognitive symptoms. Negative symptoms are usually present from the prodromal phase; early diagnosis and management of negative symptoms is a major health concern since an insidious onset dominated by negative symptoms is associated with a worse outcome. Antipsychotic medications, which are effective for treating positive symptoms, are generally ineffective for treating negative or cognitive symptoms. We present a 23-year-old woman showing severe symptoms at her first visit to our department. The patient's parents reported that their daughter had experienced several years of psychosocial decline and putative psychiatric symptoms, but no medical attention had been previously sought; as such, the diagnosis of schizophrenia with predominantly negative symptoms was very much delayed. Early onset of schizophrenia, longer duration of untreated psychosis, and severe negative symptoms, which have limited treatment options, suggested a poor prognosis. We initiated monotherapy with cariprazine, a novel antipsychotic that has recently been proven efficacious in treating schizophrenia with predominantly negative symptoms. This report describes a 52-week cariprazine treatment regimen and follows the patient's impressive clinical improvement confirmed by PANSS and CGI scores, and psychological tests.

Freshwater aquaculture has a significant role in fish production and biodiversity conservation. Due to climate change, however, the sustenance of fish farms became more challenging, endangering both people and natural values. The establishment of multi-purpose fishpond systems, utilizing ecosystem services besides fish production, could serve as a long-term solution for this problem. However, the lack of knowledge about fishponds’ ecosystem services creates an obstacle in the process. We would like to lower this barrier by mapping 13 different ecosystem services of White Lake, one of the most prominent fishpond systems in Hungary. The results of two different participatory mapping techniques indicated that standing waters, reedy areas, and canals, possessed the highest potential values in the provision of the listed ecosystem services, marking them as the most important areas for future developments. In the case of current sources, local experts linked the highest values to reedy areas and lookout towers. Participatory mapping also indicated that microclimate regulation and bird watching were the most widely used ecosystem services after fish production. By collecting and visualizing experts’ spatial data about White Lakes’ ecosystem services, our unique paper has the potential to serve future decision-making and provide a basis for further studies on this topic.

In the past few decades, multiple theoretical studies have highlighted the diverse capabilities of freshwater fishpond systems in the provision of water-related ecosystem services (ESs). However, practical studies to confirm this statement are still lacking in the scientific literature compared to other ecosystems. In this paper, we reveal the ESs of three semi-intensively managed fishpond systems in Hungary and assess the knowledge and perceptions of local experts about them and their main interactions. Between 2017 and 2019, we performed participatory research on the fishpond systems of Biharugra, Akasztó, and Szeged, conducting a total of 22 structured interviews with experts from all related stakeholder groups. Based on the interviews, we identified 16 actively used ESs (4 provisioning, 7 regulating, and 5 cultural ESs) and also revealed 19 main forms of impacts (14 positive and 5 negative) related to them. Despite their different perceptions and demands associated with fish farms, almost every expert articulated the role of semi-intensive fish farming in the sustenance of water-related natural values and ecosystem services, endangered by the ongoing effects of global warming. Besides confirming the theoretical statements of previous studies, these findings could also provide information for subsequent land-use planning, with the aim of creating more sustainable, multifunctionally used fishpond systems.