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"Pallotta, Jerry"
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The icky bug alphabet book
Introduces the characteristics and activities of insects and other crawly creatures from A to Z, beginning with the ant and concluding with the zebra butterfly.
Book
Summer Reading: Books Too Good to Miss
The books reviewed in this column make great additions to summer reading lists. Reading over the summer is an excellent way for students to maintain their skills, and these books will hold their interest and entertain them.
Journal Article
The frog alphabet book : --and other awesome amphibians
Introduces the letters of the alphabet by describing a frog or other amphibian for each letter, from the Amazon horned frog to the Zig zag salamander.
Book
Metastatic medulloblastoma remodels the local leptomeningeal microenvironment to promote further metastatic colonization and growth
Leptomeningeal metastases are the major source of morbidity and mortality for patients with medulloblastoma. The biology of the leptomeningeal metastases and the local tumour microenvironment are poorly characterized. Here we show that metastasis-associated meningeal fibroblasts (MB-MAFs) are transcriptionally distinct and signal extensively to tumour cells and the tumour microenvironment. Metastatic cells secrete platelet-derived growth factor (PDGF) ligands into the local microenvironment to chemotactically recruit meningeal fibroblasts. Meningeal fibroblasts are reprogrammed to become MB-MAFs, expressing distinct transcriptomes and secretomes, including bone morphogenetic proteins. Active bone morphogenetic protein signalling and co-implantation of tumour cells with MB-MAFs enhances the colonization of the leptomeninges by medulloblastoma cells and promotes the growth of established metastases. Furthermore, treatment of patient-derived xenograft mice with a PDGF-receptor-α neutralizing antibody enhances overall survival in vivo. Collectively, our results define a targetable intercellular communication cascade in the metastatic niche to treat leptomeningeal disease.
Abeysundara, Rasnitsyn, Fong et al. report that the presence of leptomeningeal metastatic tumour cells leads to the recruitment and remodelling of fibroblasts, which, in turn, facilitate the colonization and outgrowth of medulloblastoma cells in the leptomeninges.
Journal Article
The extinct alphabet book
Each letter of the alphabet features information about a creature that no longer exists.
Book
The ocean alphabet board book
Introduces the letters A to Z by describing fish and other creatures living in the North Atlantic Ocean.
Book
Lobster vs. crab
Contains facts about lobsters and crabs, comparing such aspects as their sizes and abilities, and what the outcome would be if they were to fight each other.
Book
The ocean alphabet book
Introduces the letters A to Z by describing fish and other creatures living in the North Atlantic Ocean.
Book
The boat alphabet book
An alphabet book presenting unusual facts about a variety of boats from aircraft carriers to zodiacs.
Book