Catalogue Search | MBRL
Are you sure you want to remove the book from the shelf?
{{itemTitle}}
3,859
result(s) for
"Palmer, David"
Sort by:
Liquid biopsies: the future of cancer early detection
Cancer is a worldwide pandemic. The burden it imposes grows steadily on a global scale causing emotional, physical, and financial strains on individuals, families, and health care systems. Despite being the second leading cause of death worldwide, many cancers do not have screening programs and many people with a high risk of developing cancer fail to follow the advised medical screening regime due to the nature of the available screening tests and other challenges with compliance. Moreover, many liquid biopsy strategies being developed for early detection of cancer lack the sensitivity required to detect early-stage cancers. Early detection is key for improved quality of life, survival, and to reduce the financial burden of cancer treatments which are greater at later stage detection. This review examines the current liquid biopsy market, focusing in particular on the strengths and drawbacks of techniques in achieving early cancer detection. We explore the clinical utility of liquid biopsy technologies for the earlier detection of solid cancers, with a focus on how a combination of various spectroscopic and -omic methodologies may pave the way for more efficient cancer diagnostics.
Journal Article
The internationalization of East Asian higher education : globalization's impact
\"Several universities throughout East Asia have been developing internationalization policies to meet the increasing demands of globalization. The editors initially viewed these policies as being more about \"Westernization\" and questioned how power and privilege are embedded within these efforts. However, we did not want to be completely skeptical of these globalization efforts. Therefore we set out to explore how globalization is impacting East Asian university systems, society, and culture. The volume investigates East Asian higher education systems in comparison and separate from Western-dominant thoughts, which can ultimately lead to innovative globalization theory and internationalization practice at the higher education level\"--Provided by publisher.
Book
3208 Experience and preliminary results of establishing a research recruitment database for FND
Background/ObjectivesFunctional neurological disorder (FND) is a common, disabling, and usually chronic neurological condition. After a long period of neglect, research interest in the area has grown rapidly in recent years. People with FND (pwFND) often express interest in enrolling in any research studies on the condition, and recruitment is frequently a rate limiting factor in studies.The traditional method of recruiting for studies: advertising and relying on prospective participants to make contact, is imperfect. It puts an onus on patients to monitor multiple sources for notification of new studies, meaning that people who might have enrolled in a study may not find out about it, or enrol later than they otherwise might have. Research recruitment databases have been shown to reduce this problem in other conditions.MethodsWe established a research recruitment database, FND Research Connect (www.fnd-research.org) where pwFND can prospectively register to be contacted about studies for which they meet inclusion criteria, and to have the information they provide for screening purposes used in an anonymised form for epidemiological research.ResultsOn a ‘soft’ initial release to Australia only, 284 pwFND enrolled for the database in the first month. One study is already being prepared for publication using data from the database. Worldwide release is planned for early March 2024.Conclusion/DiscussionFND Research Connect appears to provide a meaningful increase in the ease with which pwFND can find studies, and FND researchers can recruit for studies.
Journal Article
Magnetic resonance imaging as a readout of CLN5 gene therapy efficacy in sheep
Purpose: Neuronal ceroid lipofuscinoses (NCL; Batten disease) are a group of rare inherited neurodegenerative disorders caused by mutations in one of 13 ceroid lipofuscinosis neuronal (CLN) genes. The diseases share a common set of symptoms, including motor and cognitive dysfunction, progressive loss of vision, and seizure activity. A naturally occurring model of CLN5 NCL exists in New Zealand Borderdale sheep, which exhibit similar clinical disease and post-mortem pathology to the human disease. Recent trials of concurrent intracerebroventricular and intravitreal gene therapy in sheep with CLN5 disease confirmed the therapeutic efficacy of this approach. Given the documented natural history of brain volume changes, detected by MRI, in sheep with CLN5 disease, the current study sought to utilize MRI as both a longitudinal readout and cross-sectional measure of therapeutic efficacy in treated sheep. Method: Sheep treated at a pre-symptomatic timepoint underwent five T1-weighted structural MRI scans between 5 and 18 months of age. Sheep treated at early and advanced symptomatic disease stages underwent a single MRI at 18 months of age. All scans from treated sheep were compared to historical healthy control and affected untreated sheep at each age. Finding: Pre-symptomatic treated sheep showed growth in intracranial volume at a comparable rate to healthy control sheep over the course of the study. Whilst grey matter volume decreased and cerebrospinal fluid volume increased in treated sheep, this was to a much smaller degree than in untreated affected sheep. The majority of the cortical regions assessed showed stable volumes over the course of the study, with the notable exception of the cerebellum. Both early and advanced symptomatic treated sheep showed intracranial volumes comparable to untreated affected sheep at 18 months of age. However, when individual tissue types were assessed, grey and white matter were significantly larger, and cerebrospinal fluid was significantly smaller in early symptomatic sheep compared to untreated affected sheep, while the same volumes in advanced symptomatic treated sheep were comparable to untreated affected sheep. Cortical regions assessed showed an age-at-treatment and dose effect. Conclusion: This study has demonstrated that MRI, a clinically relevant outcome measure, can be successfully utilized to assess therapeutic efficacy in a large animal model of CLN5 NCL, both in a longitudinal study and a cross-sectional study when robust natural history data is available for comparison
Journal Article
Development of high-throughput ATR-FTIR technology for rapid triage of brain cancer
Non-specific symptoms, as well as the lack of a cost-effective test to triage patients in primary care, has resulted in increased time-to-diagnosis and a poor prognosis for brain cancer patients. A rapid, cost-effective, triage test could significantly improve this patient pathway. A blood test using attenuated total reflection (ATR)-Fourier transform infrared (FTIR) spectroscopy for the detection of brain cancer, alongside machine learning technology, is advancing towards clinical translation. However, whilst the methodology is simple and does not require extensive sample preparation, the throughput of such an approach is limited. Here we describe the development of instrumentation for the analysis of serum that is able to differentiate cancer and control patients at a sensitivity and specificity of 93.2% and 92.8%. Furthermore, preliminary data from the first prospective clinical validation study of its kind are presented, demonstrating how this innovative technology can triage patients and allow rapid access to imaging.
Diagnosing brain cancer is frequently difficult and requires specialist equipment. Here, the authors develop their previous attenuated total reflectance-Fourier transform infrared spectroscopy method and incoporate the use of disposable silicon wafers for diagnosing brain cancer using serum samples.
Journal Article
Trusted Community Spaces for Suicide Prevention: Evaluating the Ambassador Barbers, Salons, and Tattoo Studios Project in the London Borough of Bexley, UK
Men account for the majority of suicides in the United Kingdom, yet many delay seeking help due to gendered norms that discourage emotional disclosure and position vulnerability as socially risky. Everyday environments where men routinely engage in familiar, informal conversation may, therefore, offer opportunities for earlier intervention. This evaluation examined the Mind in Bexley Ambassador Project, which trained barbers, hair stylists, and tattoo artists to recognize emotional distress, initiate supportive dialogue, and signpost to local services. A total of 61 ambassadors completed training, including 24 barbers, 32 hair stylists, and 5 tattoo artists. Quantitative confidence measures, activity logs, and qualitative interviews assessed feasibility, acceptability, and early outcomes. Ambassadors reported increased confidence in recognizing distress, asking directly about suicide, and referring to support, with 1,818 mental health-related conversations and 265 signposting interactions (including provision of service-information leaflets) recorded over 7 months. Emotional disclosure typically emerged gradually across repeat appointments, where trust and familiarity were already established. Brief, evidence-informed training supported ambassadors to respond more intentionally and confidently to distress without altering the informal character of these grooming environments. The intervention legitimized and strengthened existing relational practices, positioning barbershops, salons, and tattoo studios as low-threshold, socially safe settings where distress may be recognized and voiced before reaching a crisis point. Embedding proportionate training, reflective supervision, and clear referral pathways into such everyday spaces offers a scalable and culturally congruent approach to suicide prevention for men.
Journal Article