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An ontological model of an operational theory is considered to be universally noncontextual if both preparation and measurement noncontextuality assumptions are satisfied in that model. In this report, we first generalize the logical proofs of quantum preparation and measurement contextuality for qubit system for any odd number of preparations and measurements. Based on the logical proof, we derive testable universally non-contextual inequalities violated by quantum theory. We then propose a class of two-party communication games and show that the average success probability of winning such games is solely linked to suitable Bell expression whose local bound is greater than universal non-contextual bound. Thus, for a given state, even if quantum theory does not exhibit non-locality, it may still reveal non-classicality by violating the universal non-contextual bound. Further, we consider a different communication game to demonstrate that for a given choices of observables in quantum theory, even if there is no logical proof of preparation and measurement contextuality exist, the universal quantum contextuality can be revealed through that communication game. Such a game thus test a weaker form of universal non-contextuality with minimal assumption.

Semi-device-independent certification of an unsharp instrument has recently been demonstrated (2019 New J. Phys. 21 083034) based on the sequential sharing of quantum advantages in a prepare-measure communication game by assuming the system to be qubit. In this work, we provide device-independent (DI) self-testing of the unsharp instrument through the quantum violation of two Bell inequalities where the devices are uncharacterized and the dimension of the system remains unspecified. We introduce an elegant sum-of-squares approach to derive the dimension-independent optimal quantum violation of Bell inequalities which plays a crucial role. Note that the standard Bell test cannot self-test the post-measurement states and consequently cannot self-test unsharp instrument. The sequential Bell test possess the potential to self-test an unsharp instrument. We demonstrate that there exists a trade-off between the maximum sequential quantum violations of the Clauser–Horne–Shimony–Holt inequality, and they form an optimal pair that enables the DI self-testing of the entangled state, the observables, and the unsharpness parameter. Further, we extend our study to the case of elegant Bell inequality and we argue that it has two classical bounds—the local bound and the non-trivial preparation non-contextual bound, lower than the local bound. Based on the sharing of preparation contextuality by three independent sequential observers, we demonstrate the DI self-testing of two unsharpness parameters. Since an actual experimental scenario involves losses and imperfection, we demonstrate robustness of our certification to noise.

In a bipartite Bell scenario involving two local measurements per party and two outcomes per measurement, the measurement incompatibility in one wing is both necessary and sufficient to reveal the nonlocality. However, such a one-to-one correspondence fails when one of the observers performs more than two measurements. In such a scenario, the measurement incompatibility is necessary but not sufficient to reveal the nonlocality. In this work, within the formalism of general probabilistic theory (GPT), we demonstrate that unlike the nonlocality, the incompatibility of N arbitrary measurements in one wing is both necessary and sufficient for revealing the generalised contextuality for the sub-system in the other wing. Further, we formulate an elegant form of inequality for any GPT that is necessary for N -wise compatibility of N arbitrary observables. Moreover, we argue that any theory that violates the proposed inequality possess a degree of incompatibility that can be quantified through the amount of violation. We claim that it is the generalised contextuality that provides a restriction to the allowed degree of measurement incompatibility of any viable theory of nature and thereby super-select the quantum theory. Finally, we discuss the geometrical implications of our results.

We present a self-testing protocol in a constrained prepare-measure scenario, based on a communication game known as parity-oblivious multiplexing (POM) task. In this scenario, a parity-oblivious constraint is imposed on the preparations, allowing us to define a classical bound derived from a preparation noncontextual ontological model. We demonstrate that the optimal quantum value exceeds preparation noncontextual bound and therefore enables self-testing of the preparations and the measurement devices. Contrasting the prevailing consensus that the self-testing in prepare-measure scenario inevitably requires an upper bound on the dimension of the quantum system, we derive the optimal quantum success probability of the POM task devoid of assuming the dimension of the quantum system. Furthermore, by proving the existence of a unitary, we show that the optimal preparations and measurements in an unknown but finite dimensional Hilbert space, responsible for the observed input–output correlations, can be mapped, via a unitary, onto a known finite-dimensional quantum system. Our results thus pave the way for scalable, single system based certification protocols in the prepare-measure scenario.

Objectives To summarise evidence on the association between white rice consumption and risk of type 2 diabetes and to quantify the potential dose-response relation.Design Meta-analysis of prospective cohort studies.Data sources Searches of Medline and Embase databases for articles published up to January 2012 using keywords that included both rice intake and diabetes; further searches of references of included original studies.Study selection Included studies were prospective cohort studies that reported risk estimates for type 2 diabetes by rice intake levels.Data synthesis Relative risks were pooled using a random effects model; dose-response relations were evaluated using data from all rice intake categories in each study.Results Four articles were identified that included seven distinct prospective cohort analyses in Asian and Western populations for this study. A total of 13 284 incident cases of type 2 diabetes were ascertained among 352 384 participants with follow-up periods ranging from 4 to 22 years. Asian (Chinese and Japanese) populations had much higher white rice consumption levels than did Western populations (average intake levels were three to four servings/day versus one to two servings/week). The pooled relative risk was 1.55 (95% confidence interval 1.20 to 2.01) comparing the highest with the lowest category of white rice intake in Asian populations, whereas the corresponding relative risk was 1.12 (0.94 to 1.33) in Western populations (P for interaction=0.038). In the total population, the dose-response meta-analysis indicated that for each serving per day increment of white rice intake, the relative risk of type 2 diabetes was 1.11 (1.08 to 1.14) (P for linear trend<0.001).Conclusion Higher consumption of white rice is associated with a significantly increased risk of type 2 diabetes, especially in Asian (Chinese and Japanese) populations.

Acute respiratory distress syndrome is the most severe form of acute lung injury (ALI) and is associated with significant mortality. Lipopolysaccharide (LPS)-induced injury is a valuable murine model of ALI but there is a paucity of data on lung regeneration and the role of angiogenic signaling involving vascular endothelial growth factor (VEGF). Eight-week-old male C57BL/6J mice were randomized to receive intratracheal instillation of either LPS or isovolumetric phosphate buffered saline as a vehicle control. Mice were observed at a single follow-up time-point that was either short-term (24 h or 4 days) or long-term (7 days or 4 weeks). On pulmonary function testing, LPS-treated mice had increased compliance at 4 weeks post-instillation, which correlated with decreased vascularization and with time-dependent, progressive decrease in alveolarization. Treadmill exercise tolerance testing demonstrated impaired performance at 24 h, 4 days and 4 weeks following LPS exposure. On lung protein analysis, LPS instillation decreased VEGF expression at up to 4 weeks, and decreased activation of its key receptor, VEGFR2 at 7 days and 4 weeks post-instillation. Together, these data provide insight on long-term pulmonary functional outcomes 4 weeks after ALI and identify angiogenic proteins as possible therapeutic targets following lung injury.

The layered square-planar nickelates, Nd n +1 Ni n O 2 n +2 , are an appealing system to tune the electronic properties of square-planar nickelates via dimensionality; indeed, superconductivity was recently observed in Nd 6 Ni 5 O 12 thin films. Here, we investigate the role of epitaxial strain in the competing requirements for the synthesis of the n  = 3 Ruddlesden-Popper compound, Nd 4 Ni 3 O 10 , and subsequent reduction to the square-planar phase, Nd 4 Ni 3 O 8 . We synthesize our highest quality Nd 4 Ni 3 O 10 films under compressive strain on LaAlO 3 (001), while Nd 4 Ni 3 O 10 on NdGaO 3 (110) exhibits tensile strain-induced rock salt faults but retains bulk-like transport properties. A high density of extended defects forms in Nd 4 Ni 3 O 10 on SrTiO 3 (001). Films reduced on LaAlO 3 become insulating and form compressive strain-induced c -axis canting defects, while Nd 4 Ni 3 O 8 films on NdGaO 3 are metallic. This work provides a pathway to the synthesis of Nd n +1 Ni n O 2 n +2 thin films and sets limits on the ability to strain engineer these compounds via epitaxy. The discovery of superconductivity in the infinite-layer nickelates reignites an interest in the nickelates as cuprate analogues. Here, the authors investigate the role of epitaxial strain in the synthesis of the n=3 layered nickelate, Nd 4 Ni 3 O 8 .

An amendment to this paper has been published and can be accessed via a link at the top of the paper.An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Neural substrates of emotion dysregulation in adolescent suicide attempters remain unexamined. We used functional magnetic resonance imaging to measure neural activity to neutral, mild or intense (i.e., 0%, 50% or 100% intensity) emotion face morphs in two separate emotion-processing runs (angry and happy) in three adolescent groups: (1) history of suicide attempt and depression (ATT, n=14) ; (2) history of depression alone (NAT, n=15) ; and (3) healthy controls (HC, n=15). Post-hoc analyses were conducted on interactions from 3 group x 3 condition (intensities) whole-brain analyses (p<0.05, corrected) for each emotion run. To 50% intensity angry faces, ATT showed significantly greater activity than NAT in anterior cingulate gyral–dorsolateral prefrontal cortical attentional control circuitry, primary sensory and temporal cortices; and significantly greater activity than HC in the primary sensory cortex, while NAT had significantly lower activity than HC in the anterior cingulate gyrus and ventromedial prefrontal cortex. To neutral faces during the angry emotion processing run, ATT had significantly lower activity than NAT in the fusiform gyrus. ATT also showed significantly lower activity than HC to 100% intensity happy faces in the primary sensory cortex, and to neutral faces in the happy run in the anterior cingulate and left medial frontal gyri (all p<0.006,corrected). Psychophysiological interaction analyses revealed significantly reduced anterior cingulate gyral–insula functional connectivity to 50% intensity angry faces in ATT v. NAT or HC. Elevated activity in attention control circuitry, and reduced anterior cingulate gyral–insula functional connectivity, to 50% intensity angry faces in ATT than other groups suggest that ATT may show inefficient recruitment of attentional control neural circuitry when regulating attention to mild intensity angry faces, which may represent a potential biological marker for suicide risk.

Background/Objectives: Evidence regarding the consumption of soy foods and isoflavones in relation to risk of type 2 diabetes (T2D) is scarce. Our study was to evaluate the association between soy food and isoflavone consumption and risk of T2D in US men and women. Subjects/Methods: We followed 63 115 women in the Nurses’ Health Study (1998–2012), 79 061 women in the Nurses’ Health Study II (1999–2013) and 21 281 men in the Health Professionals Follow-Up Study (2002–2010). Diet was assessed by a validated food-frequency questionnaire and was updated every 4 years. Self-reports of incident T2D were confirmed by a validated supplementary questionnaire. Results: During 1 966 321 person-years of follow-up, 9185 incident T2D cases were documented. After multivariate adjustment for covariates, consumption of soy foods (tofu and soy milk) was not associated with a lower T2D risk. Compared with non-consumers of soy foods, the hazard ratio (HR) was 1.00 (95% confidence interval (CI): 0.93, 1.07) for <1 serving/week and 0.93 (95% CI: 0.83, 1.03) for ⩾1 serving/week of soy foods ( P for trend=0.14). In contrast, intake of total isoflavones was inversely associated with T2D risk. Comparing extreme quintiles of isoflavones, the HR was 0.89 (95% CI: 0.83, 0.96; P for trend=0.009). Inverse associations were also found for consumption of major individual isoflavones, including daidzein and genistein, with risk of T2D. Conclusions: Intake of isoflavones was associated with a modestly lower T2D risk in US men and women who typically consumed low-to-moderate amounts of soy foods. These findings warrant replications in other populations with similar soy intake levels.