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Nuclear reactors are a source of electron antineutrinos due to the presence of unstable fission products that undergo β - decay. They will be exploited by the JUNO experiment to determine the neutrino mass ordering and to get very precise measurements of the neutrino oscillation parameters. This requires the reactor antineutrino spectrum to be characterized as precisely as possible both through high-resolution measurements, as foreseen by the TAO experiment, and detailed simulation models. In this paper, we present a benchmark analysis utilizing Serpent Monte Carlo simulations in comparison with real pressurized water reactor spent fuel data. Our objective is to study the accuracy of fission fraction predictions as a function of different reactor simulation approximations. Then, using the BetaShape software, we construct reactor antineutrino spectrum using the summation method, thereby assessing the influence of simulation uncertainties on it.

The main source of systematic uncertainty on neutrino cross section measurements at the GeV scale originates from the poor knowledge of the initial flux. The reduction of this uncertainty to 1% can be achieved through the monitoring of charged leptons produced in association with neutrinos. The goal of the ENUBET ERC project is to prove the feasibility of such a monitored neutrino beam. In this contribution, the final results of the ERC project, together with the complete assessment of the feasibility of its concept, are presented. An overview of the detector technology for a next generation of high precision neutrino-nucleus cross section measurements, to be performed with the ENUBET neutrino beam, is also given.

BackgroundNoninsertional Achilles tendinopathy is a degenerative overuse disorder. No method has been universally successful in treating this condition. Topically applied nitric oxide has been shown, in animal models, to be effective for the treatment of fractures and cutaneous wounds through mechanisms that may include stimulation of collagen synthesis in fibroblasts. The goal of the present study was to determine if topical glyceryl trinitrate improves clinical outcome measures in patients with Achilles tendinopathy.MethodsA prospective, randomized, double-blind, placebo-controlled trial involving a total of sixty-five patients (eighty-four Achilles tendons) was performed to compare continuous application of topical glyceryl trinitrate (at a dosage of 1.25 mg per twenty-four hours) with rehabilitation alone for the treatment of noninsertional Achilles tendinopathy.ResultsCompared with the control group, the glyceryl trinitrate group showed reduced pain with activity at twelve weeks (p = 0.02) and twenty-four weeks (p = 0.03), reduced night pain at twelve weeks (p = 0.04), reduced tenderness at twelve weeks (p = 0.02), decreased pain scores after the hop test at twenty-four weeks (p = 0.005), and increased ankle plantar flexor mean total work compared with the baseline level at twenty-four weeks (p = 0.04). Twenty-eight (78%) of thirty-six tendons in the glyceryl trinitrate group were asymptomatic with activities of daily living at six months, compared with twenty (49%) of forty-one tendons in the placebo group (p = 0.001, chi-square analysis). The mean effect size for all outcome measures was 0.14.ConculsionsTopical glyceryl trinitrate significantly reduced pain with activity and at night, improved functional measures, and improved outcomes in patients with Achilles tendinopathy.Level of EvidenceTherapeutic study, Level I-1a (randomized controlled trial [significant difference]). See Instructions to Authors for a complete description of levels of evidence.

The ENUBET ERC project, also included in the CERN Neutrino Platform as NP06/ENUBET, is developing a new neutrino beam based on conventional techniques in which the flux and the flavor composition are known with unprecedented precision ( O (1%)). Such a goal is accomplished monitoring the associated charged leptons produced in the decay region of the ENUBET facility. Positrons and muons from kaon decays are measured by a segmented calorimeter instrumenting the walls of the decay tunnel, while muon stations after the hadron dump can be used to monitor the neutrino component from pion decays. Furthermore, the narrow momentum width (<10%) of the beam provides a precise measurement ( O (10%)) of the neutrino energy on an event by event basis, thanks to its correlation with the radial position of the interaction at the neutrino detector. ENUBET is therefore an ideal facility for a high precision neutrino cross-section measurement at the GeV scale, that could enhance the discovery potential of the next-generation of long baseline experiments. It is also a powerful tool for testing the sterile neutrino hypothesis and to investigate possible non-standard interactions.

Childhood maltreatment, through epigenetic modification of the glucocorticoid receptor gene ( NR3C1 ), influences the hypothalamic–pituitary–adrenal axis (HPA axis). We investigated whether childhood maltreatment and its severity were associated with increased methylation of the exon 1 F NR3C1 promoter, in 101 borderline personality disorder (BPD) and 99 major depressive disorder (MDD) subjects with, respectively, a high and low rate of childhood maltreatment, and 15 MDD subjects with comorbid post-traumatic stress disorder (PTSD). Childhood sexual abuse, its severity and the number of type of maltreatments positively correlated with NR3C1 methylation ( P =6.16 × 10 −8 , 5.18 × 10 −7 and 1.25 × 10 −9 , respectively). In BPD, repetition of abuses and sexual abuse with penetration correlated with a higher methylation percentage. Peripheral blood might therefore serve as a proxy for environmental effects on epigenetic processes. These findings suggest that early life events may permanently impact on the HPA axis though epigenetic modifications of the NR3C1 . This is a mechanism by which childhood maltreatment may lead to adulthood psychopathology.

Fast-bowlers in cricket subject their spines to repetitive stress. The aim of this study was to review the prevalence of lumbar spine injuries among fast-bowlers. Medline and embase searches were performed. Further, the authors canvassed the reference list of available articles and used other search engines such as Google Scholar to identify a total of nine studies. The prevalence of lumbar disc degeneration in fast-bowlers ranges from 21-65% with an incidence rate of 15% per year, and the prevalence of lumbar spine bony abnormalities ranges from 24-81%. Factors associated with lumbar spine injury in fast-bowlers are classified into un-modifiable (age) and modifiable (more intense bowling workload and mixed-bowling technique). Fast-bowlers have a high prevalence of lumbar spine injuries. Appropriate interventions, such as educational sessions, may be able to modify risk factors such as bowling workload and bowling technique and thus reduce injury prevalence.

The NESSiE Collaboration has been setup to undertake a conclusive experiment to clarify the muon-neutrino disappearance measurements at short baselines in order to put severe constraints to models with more than the three-standard neutrinos. To this aim the current FNAL-Booster neutrino beam for a Short-Baseline experiment was carefully evaluated by considering the use of magnetic spectrometers at two sites, near and far ones. The detector locations were studied, together with the achievable performances of two OPERA-like spectrometers. The study was constrained by the availability of existing hardware and a time-schedule compatible with the undergoing project of multi-site Liquid–Argon detectors at FNAL. The settled physics case and the kind of proposed experiment on the Booster neutrino beam would definitively clarify the existing tension between the ν μ disappearance and the ν e appearance/disappearance at the eV mass scale. In the context of neutrino oscillations the measurement of ν μ disappearance is a robust and fast approach to either reject or discover new neutrino states at the eV mass scale. We discuss an experimental program able to extend by more than one order of magnitude (for neutrino disappearance) and by almost one order of magnitude (for antineutrino disappearance) the present range of sensitivity for the mixing angle between standard and sterile neutrinos. These extensions are larger than those achieved in any other proposal presented so far.

Shashlik calorimeters equipped with a compact readout based on Silicon PhotoMultipliers can be longitudinally segmented by directly coupling the WLS fibers with the photosensors thus embedding the readout in the bulk of the calorimeter. Results on energy resolution and particle identification for such calorimeters are presented. The SiPMs for the readout have also been characterized after being exposed to neutron fluences up to 2×1011 n/cm2 (1 MeV eq.). Alternative options for the active material were also investigated; we studied in particular polysiloxane as a substitute for plastic scintillator.

Introduction:Non-steroidal anti-inflammatory drugs (NSAID) are commonly used in sports medicine. NSAID have known anti-inflammatory, analgesic, antipyretic and antithrombotic effects, although their in-vivo effects in treating musculoskeletal injuries in humans remain largely unknown. NSAID analgesic action is not significantly greater than paracetamol for musculoskeletal injury but they have a higher risk profile, with side-effects including asthma exacerbation, gastrointestinal and renal side-effects, hypertension and other cardiovascular diseases.Discussion:The authors recommend an approach to NSAID use in sports medicine whereby simple analgesia is preferentially used when analgesia is the primary desired outcome. However, based both on the current pathophysiological understanding of most injury presentations and the frequency that inflammation may actually be a component of the injury complex, it is premature to suppose that NSAID are not useful to the physician managing sports injuries. The prescribing of NSAID should be cautious and both situation and pathology specific. Both dose and duration minimisation should be prioritised and combined with simple principles of protection, rest, ice, compression, elevation (PRICE), which should allow NSAID-sparing. NSAID use should always be coupled with appropriate physical rehabilitation.Conclusion:NSAID are probably most useful for treating nerve and soft-tissue impingements, inflammatory arthropathies and tenosynovitis. They are not generally indicated for isolated chronic tendinopathy, or for fractures. The use of NSAID in treating muscle injury is controversial. Conditions in which NSAID use requires more careful assessment include ligament injury, joint injury, osteoarthritis, haematoma and postoperatively.

The next generation of neutrino experiments requires measurements of absolute neutrino cross sections at the GeV scale with high precision (∼1%) presently limited by the uncertainties on neutrino flux. Monitoring the lepton production in the decay tunnel of neutrino beams is the most straightforward way to measure the neutrino flux at source. The ENUBET Collaboration develops novel technologies to monitor positrons from K+ → νee+π0 decays on an event by event basis. This technique can achieve a precision in the νe flux below 1% and enable a new generation of cross section and short baseline experiments. In this paper, we present the achievements of the first year of the Project on beamline simulation, rate and dose assessment, detector prototyping and evaluation of the physics reach.