Explore the vast range of titles available.

Colorectal cancer is a common cancer in Indonesia, yet it has been understudied in this resource-constrained setting. We conducted a genome-wide association study focused on evaluation and preliminary discovery of colorectal cancer risk factors in Indonesians. We administered detailed questionnaires and collecting blood samples from 162 colorectal cancer cases throughout Makassar, Indonesia. We also established a control set of 193 healthy individuals frequency matched by age, sex, and ethnicity. A genome-wide association analysis was performed on 84 cases and 89 controls passing quality control. We evaluated known colorectal cancer genetic variants using logistic regression and established a genome-wide polygenic risk model using a Bayesian variable selection technique. We replicate associations for rs9497673, rs6936461 and rs7758229 on chromosome 6; rs11255841 on chromosome 10; and rs4779584, rs11632715, and rs73376930 on chromosome 15. Polygenic modeling identified 10 SNP associated with colorectal cancer risk. This work helps characterize the relationship between variants in the SCL22A3 , SCG5 , GREM1 , and STXBP5-AS1 genes and colorectal cancer in a diverse Indonesian population. With further biobanking and international research collaborations, variants specific to colorectal cancer risk in Indonesians will be identified.

As the fourth most populous country in the world, Indonesia must increase the annual rice production rate to achieve national food security by 2050. One possible solution comes from the nanoscopic level: a genetic variant called Single Nucleotide Polymorphism (SNP), which can express significant yield-associated genes. The prior benchmark of this study utilized a statistical genetics model where no SNP position information and attention mechanism were involved. Hence, we developed a novel deep polygenic neural network, named the NucleoNet model, to address these obstacles. The NucleoNets were constructed with the combination of prominent components that include positional SNP encoding, the context vector, wide models, Elastic Net, and Shannon’s entropy loss. This polygenic modeling obtained up to 2.779 of Mean Squared Error (MSE) with 47.156% of Symmetric Mean Absolute Percentage Error (SMAPE), while revealing 15 new important SNPs. Furthermore, the NucleoNets reduced the MSE score up to 32.28% compared to the Ordinary Least Squares (OLS) model. Through the ablation study, we learned that the combination of Xavier distribution for weights initialization and Normal distribution for biases initialization sparked more various important SNPs throughout 12 chromosomes. Our findings confirmed that the NucleoNet model was successfully outperformed the OLS model and identified important SNPs to Indonesian rice yields.

Jakarta lifted up lockdown after passing more than 50 days of large-scale social activity restriction and initiated phase opening to new normal. To analyse Jakarta’s air quality after passing lockdown, a pipeline of data engineering is needed. By acquiring time series data from openaq.com, a time-series database system is developed with Python programming language and its fundamental libraries namely Pandas, NumPy, SQLite. After PM 2.5 data are pre-processed into average per-hour and grouped by applicable periods (pre-lockdown, lockdown, and phase opening), a pattern of PM 2.5 in South Jakarta is revealed by using data visualization library Matplotlib. The apex of PM 2.5 occurs earlier during lockdown (04:00) and phase opening (02:00) rather than when it was normal or pre-lockdown (08:00) even though the nadir of PM2.5 still occurs at the same time (16:00 – 17:00).

Antimicrobial resistance (AMR) poses one of the major risks for the current and future global public health. Gram-negative pathogens with their unique outer membrane are regularly put on the WHO critical priority list to tackle the AMR challenges. The rapid and collaborative developments of high-efficacy antibiotics against these bacteria are thus highly anticipated. For example, outer membrane proteins of Gram-negative bacteria are currently promising targets for novel antimicrobial drugs. Advances in current computing technology may aid in designing a well-targeted experiment study and understanding the molecular mechanism of the drugs. In this study, we demonstrate how to build a model and a simulation setup of ß-barrel assembly machinery A protein embedded in an outer membrane of Escherichia Coli using two different model resolutions: atomistic and coarse-grained force fields. We employed atomistic parameters from the CHARMM force field and novel lipopolysaccharides parameters in the Martini 3 force field. The built models were shown to be stable as the energy minimization procedure can achieve convergence within an appropriate potential energy range. The modeling pipeline demonstrated in this preliminary study is expected to facilitate the in-silico development of antibiotics for combating different Gram-negative pathogens.

As the global demand for food continue to increase, it is important to find a way to meet the demand without creating any problems to the environment. Cyanobacteria have a prospective to be utilised for the modern agriculture, as they contribute to the improvement of the soil fertility, the crop yield, and they also do not harm the environment. Therefore, it is crucial to understand the species of cyanobacteria or the characteristics that could be used for modern agriculture. The development of Next-Generation Sequencing (NGS) technologies enables us to study the genome of cyanobacteria. Thus, we can study their characteristics by analysing the NGS data. This paper aims to elaborate a pipeline for genomic analysis on cyanobacteria from NGS data. We used a free Linux-based software tool, namely Breseq to process the NGS sequencing raw data. This tool predicts mutations that occur in the genome of the sample, including single- nucleotide variation, insertions, and deletions which could be beneficial for the identification of a new species or a mutant of cyanobacteria which has the right characteristics for modern agriculture utilisation.

Tuberculosis (TB) is one of the highest causes of death in Indonesia. The main reason is lack of the health facilities. Computer-aided diagnosis (CAD) is a tool for early treatment and screening of many diseases, including TB. This paper proposed a design of a CAD system in Indonesia specifically for TB. The design gives the analysis of self-assessment concepts, use-case diagrams, and black-box diagrams. The black box utilizes chest x-ray (CXR) data for the medical image processing (MIP) method, and artificial intelligence (AI) for classification and visualization of the TB. This CAD design of self-assessment of TB has a capability to help the health practitioners read and interpret the diagnosis result more easily.

Indonesia is a country with a tropical climate so that fruit and vegetable plants can grow easily in Indonesia.Fruits have many good nutrients such as vitamins, proteins and others. But the fruit also has a period where the fruit is said to be fresh fruit.During this time there are still many fruit supplier companies that send fruit unfit for consumption due to lack of accuracy in the process of sorting the fruit when the fruit is taken from the plantation and the entry of other fruit into an improper packaging. Thus, it makes detecting food spoilage from the production stage to consumption is very important. We propose a design of computer vision-based technique usingdeep learning with the Convolutional Neural Network (CNN) model to detect fruit freshness. The specially designed CNN model is then evaluated with public datasets of fruits fresh and rotten for classification derived from Kaggle.

Background: In this paper, we examine how social media influencers can influence visit intention, especially in the case of Raffi Ahmad and Nagita Slavina, a top influencer who by 2 September 2021 had reached 21.3 M subscribers on YouTube and 54.9 m followers on Instagram with an engagement rate of 0.42%. The focus of this study is Generation Y or Millennials (born 1981–1996) and Generation Z (born 1997–2012). Design/methodology/approach: Snowball sampling was performed to arrive at a representative group of Millennials. Data analysis was performed using hierarchical likelihood via structural equation modeling. Findings: The study results are helpful for a comprehensive understanding of factors affecting visit intention. Effects of the study results summary, tourists from Generations Y and Z are thriving within the internet of things and the digital age, an era in which information can be accessed via various forms of technology across multiple platforms. Practical implications: We discuss and identify the relative importance of each factor through the use of logistics with variational approximation and structural equation models using hierarchical likelihood. Originality: The technique we use is an integrated and extended version of the structural equation model with hierarchical likelihood estimation and features selection using logistics variational approximation.

Design: Health issues throughout the sustainable development goals have also been integrated into one ultimate goal, which helps to ensure a healthy lifestyle as well as enhances well-being for any and all human beings of all social level. Meanwhile, regarding the clime change, we may take urgent action to its impacts. Purpose: Nowadays, climate change makes it much more difficult to control the pattern of diseases transmitted and sometimes hard to prevent. In line with this, Centres for Disease Control (CDC) Taiwan grouped the spread of disease through its source in the first six main groups. Those are food or waterborne, airborne or droplet, vector-borne, sexually transmitted or blood-borne, contact transmission, and miscellaneous. According to this, academics, government, and the private sector should work together and collaborate to maintain the health issue. This article examines and connects the climate and communicable aspects towards Penta-Helix in Taiwan. Finding: In summary, we have been addressing the knowledge center on the number of private companies throughout the health care sector, the number of healthcare facilities, and the education institutions widely recognized as Penta Helix. In addition, we used hierarchical likelihood structural equation modeling (HSEMs). All the relationship variables among climate, communicable disease, and Penta Helix can be interpreted through the latent variables with GoF 79.24%.

Weeds are one of the organisms that interfere with plant growth. Information about the identity of weeds becomes very important on plantations. Although weeds data digitization has been done a lot, currently there is still not much weeds data information system can be accessed online. Weeds management is often dealt with weeds herbarium or weeds photographs. In an effort to provide a good information system for farmers, this research aims to create a database of various types of weeds and an information system that can be accessed online. The methodology for developing a weed catalog information system uses the Software Development Life Cycle (SDLC). Weed samples in database were collected through systematic random sampling in the form of images and text. The result of this study is a Weeds Electronic Catalog or Weeds e-Catalog that can facilitate the information of weeds identity such as names, classifications, morphology, life cycles, and habitats of various types of weeds that grow on plantation land. Weeds e-Catalog can be used by plantation practitioners and farmers to make decisions in controlling weeds.