Explore the vast range of titles available.

We document that an increase in short-horizon investors is associated with cuts to long-term investment and increased short-term earnings. This leads to temporary boosts in equity valuations that reverse over time. To estimate these effects, we use difference-in-differences regressions around firms’ additions to the Russell 2000, comparing firms with large and small increases in short-term ownership. We proxy for the presence of short-term investors using ownership by transient institutions. Our results suggest that short-term pressures by investors can lead to myopic firm behavior. This paper was accepted by Shiva Rajgopal, accounting .

This study proposes that the performance of mutual fund managers is linked to how efficiently they allocate attention across assets in their investment set. Motivated by existing models of optimal portfolio choice and rational inattention, we posit that the efficiency of attention allocation increases when a manager chooses larger (smaller) active positions in assets that need more (less) information acquisition effort to resolve uncertainty about future payoffs. We show that the efficiency of attention allocation has a significantly positive impact on future fund performance. Efficient attention allocation has a lesser impact on performance as the total demands on a manager's limited attention increase.

This study proposes that the performance of mutual fund managers is linked to how efficiently they allocate attention across assets in their investment set. Motivated by existing models of optimal portfolio choice and rational inattention, we posit that the efficiency of attention allocation increases when a manager chooses larger (smaller) active positions in assets that need more (less) information acquisition effort to resolve uncertainty about future payoffs. We show that the efficiency of attention allocation has a significantly positive impact on future fund performance. Efficient attention allocation has a lesser impact on performance as the total demands on a manager's limited attention increase.

The electrical discharge machining commonly used nonconventional machining process for making dies. TheH11 die steels are commonly used for making forging and casting dies. In the present research, the effect of Al2O3 powder in de-ionized water as dielectric fluid, pulse on time, current, voltage on metal removal rate (MRR) have been investigated. The result shows that MRR increases with increase in pulse on time and current. Also, The MRR increases with the presence of Al2O3 powder in de-ionized water.

In the first chapter, I examine the effect of information networks on the trading behavior of mutual funds and on stock returns. An information or stock ownership linkage between two mutual funds is defined by large positions in the same stock. Mutual funds trade together with other funds in their information network after controlling for the overall trading behavior of the mutual fund sector. The effect is robust and cannot be explained by style investing or geographic location. The paper also examines the effect of the structure of information networks on stock returns and stock volatility. Using network density as a measure for the speed of information diffusion in a network of investors, I find that stocks with a lower network density demonstrate stronger return momentum at medium horizons and stronger return reversal in the long run. The evidence is consistent with the gradual information diffusion model of Hong and Stein (1999). Finally, I provide empirical evidence in support of recent theoretical models that study the asset pricing implications of social networks. I show that centralized information networks lead to a higher volatility of individual stocks in the cross-section and also explain the variation in average stock idiosyncratic volatility over time. The second chapter focuses on the effect of the firm's information network on underreaction to earnings news. Using size-adjusted network density as a measure for the speed of information diffusion, I find that the underreaction to earnings news increases with decrease in network density. This association between network density and underreaction to earnings news becomes stronger with increasing information uncertainty and is insignificant for the stocks with low information uncertainty. The findings provide evidence for a gradual information diffusion based explanation for underreaction to earnings news with an assumption that flow of private information is required to ascertain the effect of new public information on the firm's value. In the third chapter (co-authored with Martijn Cremers), we examine the effect of institutional investors' investment duration on the efficiency of stock prices. Using a new duration measure based on quarterly institutional investors' portfolio holdings, the presence of short-term institutional investors can help explain many of the best-known stock return anomalies, possibly because these investors are affected by behavioral biases like overconfidence. Specifically, we find that both momentum returns and subsequent returns reversal are much stronger for stocks with greater proportions of short-term institutional investors. The accruals and share issuance anomalies are also stronger for stocks held primarily by short-term institutional investors. Finally, short-term institutional investors do not seem to recognize the benefits of significant R&D increases, as they tend to under-react to these increases.

The world has now entered into a new era of genomics because of the continued advancements in the next generation high throughput sequencing technologies, which includes sequencing by synthesis-fluorescent in situ sequencing (FISSEQ), pyrosequencing, sequencing by ligation using polony amplification, supported oligonucleotide detection (SOLiD), sequencing by hybridization along with sequencing by ligation, and nanopore technology. Great impacts of these methods can be seen for solving the genome related problems of plant and animal kingdom that will open the door of a new era of genomics. This may ultimately overcome the Sanger sequencing that ruled for 30 years. NGS is expected to advance and make the drug discovery process more rapid.

Through this erratum the authors declare that two coauthors were missing in the article entitled “Next generation sequencing: potential and application in drug discovery”. The correct list of the authors and their affiliations are as shown above.

Molecular interactions of Chikungunya virus (CHIKV) non-structural protein 3 (nsP3) with GTPase Activating Protein SH3 Domain Binding Protein 1 (G3BP1) host protein is important for efficient replication of CHIKV. CHIKV nsP3 protein binds to the nuclear transport factor 2 (NTF2)-like domain of G3BP1 via two tandem FGDF motifs and disrupts the stress granules (SGs) formation. Interestingly, this makes the G3BP1 host protein an additional drug target for antiviral research. In this study, seven potential small molecules targeting FGDF motif binding pocket of G3BP1 have been identified using structure-based virtual screening approach. Binding energies and binding modes of the molecules were further analyzed in detail through molecular docking, dynamics and simulations. Surface Plasmon Resonance (SPR) and Isothermal Titration Calorimetry (ITC) experiments confirmed the binding of identified molecules to purified G3BP1 with binding affinities in micromolar (μM) range. The antiviral efficacy of molecules targeting G3BP1 was evaluated by in vitro cell culture-based antiviral studies. All seven molecules L-7, WIN, SB2, NAL, DHD, GSK and FLU effectively diminished the CHIKV replication with EC50 values of 1.996, 0.403, 5.387, 1.528, 7.394, 3.664, and 0.618 μM, respectively. Moreover, the CHIKV infected cells treated with these molecules seemed to have fewer virus-induced SGs than virus infected control cells. Interestingly, the inhibitors showed no adverse effect on SG formation in oxidative stress condition. It further substantiated that these inhibitors effectively bind to the NTF2-like domain of G3BP1, obstruct the nsP3-G3BP1 interactions, and halts virus replication. This is the first report of small molecules targeting G3BP1, the host protein playing a crucial role in CHIKV viral replication and in the formation of SGs for host antiviral response.Competing Interest StatementThe authors have declared no competing interest.