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Fungal infections have increased at an alarming rate as a result of increased usage of immunosuppressive therapies, growing resistance to antifungal drugs, and global warming. This recently prompted the World Health Organization to publish the first-ever fungal priority pathogens list, which focused on 19 organisms, ultimately deeming 4 pathogens of critical importance based on perceived public health importance. Among these four was the opportunistic mold Aspergillus fumigatus , the etiological agent of the most lethal fungal infection known to humans, IPA. Innate immunity is paramount for controlling IPA with protective roles identified for multiple myeloid cell types. In the current report, employing three complementary animal models, we show that cDC1s hinder the clearance of A. fumigatus from the lung. We further identified specific responses that are regulated by cDC1s. Overall, our study uncovers a new mechanism of immune regulation during IPA.

The ENUBET project is aimed at designing and experimentally demonstrating the concept of monitored neutrino beams. These novel beams are enhanced by an instrumented decay tunnel, whose detectors reconstruct large-angle charged leptons produced in the tunnel and give a direct estimate of the neutrino flux at the source. These facilities are thus the ideal tool for high-precision neutrino cross-section measurements at the GeV scale because they offer superior control of beam systematics with respect to existing facilities. In this paper, we present the first end-to-end design of a monitored neutrino beam capable of monitoring lepton production at the single particle level. This goal is achieved by a new focusing system without magnetic horns, a 20 m normal-conducting transfer line for charge and momentum selection, and a 40 m tunnel instrumented with cost-effective particle detectors. Employing such a design, we show that percent precision in cross-section measurements can be achieved at the CERN SPS complex with existing neutrino detectors.

The main physics program of the CERN Super Proton Synchrotron (SPS) is dedicated to the fixed target physics experiments hosted in the North experimental Area (NA). Protons are delivered to the NA via third-integer resonant slow extraction over an almost 5 s flattop. In order to maximize the usable intensity delivered to the experiments, the flux of extracted particles should be kept as constant as possible. This is a very general requirement for fixed target experiments served by synchrotrons. Power supply ripples are a well-known issue in resonant slow extraction, affecting the quality of the spill. A long-standing effort is ongoing at CERN to characterize the SPS slow extraction frequency response to its main power supplies. In this paper, beam dynamics simulations are employed to understand and characterize the process, combined with dedicated beam based measurements.

Losses and component activation are limiting performance factors for slow extraction with high-power applications, and new techniques of loss-reduction, such as bent crystals, require a stable and narrow separatrix angular spread. Conventional tune-sweep slow extraction results in an optics change and an accompanying separatrix rotation through the spill. This can be compensated by a dynamic closed-orbit bump, but requires a high level of complexity for setting up and monitoring. For the Super Proton Synchrotron (SPS), a simpler and powerful new extraction technique has been developed and deployed, providing a mechanism to fix the machine optics and hence separatrix completely through the spill. The technique with the name constant optics slow extraction (COSE) relies on high chromaticity and scaling all machine settings with beam rigidity following the momentum distribution of the beam. In this paper we describe the new COSE concept and its successful operational deployment in the SPS during the 2018 run.

Shashlik calorimeters equipped with a compact readout based on Silicon PhotoMultipliers can be longitudinally segmented by directly coupling the WLS fibers with the photosensors thus embedding the readout in the bulk of the calorimeter. Results on energy resolution and particle identification for such calorimeters are presented. The SiPMs for the readout have also been characterized after being exposed to neutron fluences up to 2×1011 n/cm2 (1 MeV eq.). Alternative options for the active material were also investigated; we studied in particular polysiloxane as a substitute for plastic scintillator.

The charge-conjugation and parity-reversal (CP) symmetry of fundamental particles is a symmetry between matter and antimatter. Violation of this CP symmetry was first observed in 1964 1 , and CP violation in the weak interactions of quarks was soon established 2 . Sakharov proposed 3 that CP violation is necessary to explain the observed imbalance of matter and antimatter abundance in the Universe. However, CP violation in quarks is too small to support this explanation. So far, CP violation has not been observed in non-quark elementary particle systems. It has been shown that CP violation in leptons could generate the matter–antimatter disparity through a process called leptogenesis 4 . Leptonic mixing, which appears in the standard model’s charged current interactions 5 , 6 , provides a potential source of CP violation through a complex phase δ CP , which is required by some theoretical models of leptogenesis 7 – 9 . This CP violation can be measured in muon neutrino to electron neutrino oscillations and the corresponding antineutrino oscillations, which are experimentally accessible using accelerator-produced beams as established by the Tokai-to-Kamioka (T2K) and NOvA experiments 10 , 11 . Until now, the value of δ CP has not been substantially constrained by neutrino oscillation experiments. Here we report a measurement using long-baseline neutrino and antineutrino oscillations observed by the T2K experiment that shows a large increase in the neutrino oscillation probability, excluding values of δ CP that result in a large increase in the observed antineutrino oscillation probability at three standard deviations (3 σ ). The 3 σ confidence interval for δ CP , which is cyclic and repeats every 2π, is [−3.41, −0.03] for the so-called normal mass ordering and [−2.54, −0.32] for the inverted mass ordering. Our results indicate CP violation in leptons and our method enables sensitive searches for matter–antimatter asymmetry in neutrino oscillations using accelerator-produced neutrino beams. Future measurements with larger datasets will test whether leptonic CP violation is larger than the CP violation in quarks. The T2K experiment constrains CP symmetry in neutrino oscillations, excluding 46% of possible values of the CP violating parameter at a significance of three standard deviations; this is an important milestone to test CP symmetry conservation in leptons and whether the Universe’s matter–antimatter imbalance originates from leptons.

The next generation of neutrino experiments requires measurements of absolute neutrino cross sections at the GeV scale with high precision (∼1%) presently limited by the uncertainties on neutrino flux. Monitoring the lepton production in the decay tunnel of neutrino beams is the most straightforward way to measure the neutrino flux at source. The ENUBET Collaboration develops novel technologies to monitor positrons from K+ → νee+π0 decays on an event by event basis. This technique can achieve a precision in the νe flux below 1% and enable a new generation of cross section and short baseline experiments. In this paper, we present the achievements of the first year of the Project on beamline simulation, rate and dose assessment, detector prototyping and evaluation of the physics reach.

A bstract Neutrino oscillation experiments provide a unique window in exploring several new physics scenarios beyond the standard three flavour. One such scenario is quantum decoherence in neutrino oscillation which tends to destroy the interference pattern of neutrinos reaching the far detector from the source. In this work, we study the decoherence in neutrino oscillation in the context of the ESSnuSB experiment. We consider the energy-independent decoherence parameter and derive the analytical expressions for P μe and P μμ probabilities in vacuum. We have computed the capability of ESSnuSB to put bounds on the decoherence parameters namely, Γ 21 and Γ 32 and found that the constraints on Γ 21 are competitive compared to the DUNE bounds and better than the most stringent LBL ones from MINOS/MINOS+. We have also investigated the impact of decoherence on the ESSnuSB measurement of the Dirac CP phase δ CP and concluded that it remains robust in the presence of new physics.

This paper presents the expected sensitivity to the neutrino oscillation parameters of the Hyper-Kamiokande long-baseline program. The Hyper-Kamiokande experiment, currently under construction in Japan, will measure the oscillations of accelerator-produced neutrinos with thousands of selected events per sample: this corresponds to an increase of statistics of a factor 25–100 with respect to recent results from the currently-running long-baseline neutrino oscillation experiment in Japan, T2K. In the most favorable scenario we will achieve the discovery of Charge-Parity (CP) violation in neutrino oscillation at$$5\\sigma $$5 σ C.L. in less than 3 years. With 10 years of data-taking, and assuming a neutrino : antineutrino beam running ratio of 1:3, a CP violation discovery at$$5\\sigma $$5 σ C.L. is possible for more than 60% of the actual values of the CP-violating phase,$$\\delta _{CP}.$$δ CP . Moreover, we will measure$$\\delta _{CP}$$δ CP with a precision ranging from 20$$^{\\circ },$$∘ , in the case of maximal CP violation, to 6$$^{\\circ },$$∘ , in the case of CP conservation. We aim to achieve a 0.5% resolution on the$$\\Delta m^2_{32}$$Δ m 32 2 parameter, and a resolution between 3% and 0.5% on the$$\\sin ^2\\theta _{23}$$sin 2 θ 23 parameter, depending on its true value. These results are obtained by extending the analysis methods of T2K with dedicated tuning to take into account the Hyper-Kamiokande design: the larger far detector, the more powerful beam, the upgraded near detector ND280, and the planned additional Intermediate Water Cherenkov Detector.

A bstract This study provides an analysis of atmospheric neutrino oscillations at the ESSnuSB far detector facility. The prospects of the two cylindrical Water Cherenkov detectors with a total fiducial mass of 540 kt are investigated over 10 years of data taking in the standard three-flavor oscillation scenario. We present the confidence intervals for the determination of mass ordering, θ 23 octant as well as for the precisions on sin 2 θ 23 and Δ m 31 2 . It is shown that mass ordering can be resolved by 3 σ CL (5 σ CL) after 4 years (10 years) regardless of the true neutrino mass ordering. Correspondingly, the wrong θ 23 octant could be excluded by 3 σ CL after 4 years (8 years) in the case where the true neutrino mass ordering is normal ordering (inverted ordering). The results presented in this work are complementary to the accelerator neutrino program in the ESSnuSB project.