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Business skills all-in-one
There are some things that will never go out of style, and good business skills are one of them. With the help of this informative book, youll learn how to wear multiple hats in the workplace no matter what comes your waywithout ever breaking a sweat.Compiled from eight of the best Dummies books on business skills topics, Business Skills All-in-One For Dummies offers everything you need to hone your abilities and translate them into a bigger paycheck. Whether youre tasked with marketing or accounting responsibilitiesor anything in betweenthis all-encompassing reference makes it easier than ever to tackle your job with confidence.
Book
Loss of Leucine-Rich Repeat Kinase 2 (LRRK2) in Rats Leads to Progressive Abnormal Phenotypes in Peripheral Organs
The objective of this study was to evaluate the pathology time course of the LRRK2 knockout rat model of Parkinson's disease at 1-, 2-, 4-, 8-, 12-, and 16-months of age. The evaluation consisted of histopathology and ultrastructure examination of selected organs, including the kidneys, lungs, spleen, heart, and liver, as well as hematology, serum, and urine analysis. The LRRK2 knockout rat, starting at 2-months of age, displayed abnormal kidney staining patterns and/or morphologic changes that were associated with higher serum phosphorous, creatinine, cholesterol, and sorbitol dehydrogenase, and lower serum sodium and chloride compared to the LRRK2 wild-type rat. Urinalysis indicated pronounced changes in LRRK2 knockout rats in urine specific gravity, total volume, urine potassium, creatinine, sodium, and chloride that started as early as 1- to 2-months of age. Electron microscopy of 16-month old LRRK2 knockout rats displayed an abnormal kidney, lung, and liver phenotype. In contrast, there were equivocal or no differences in the heart and spleen of LRRK2 wild-type and knockout rats. These findings partially replicate data from a recent study in 4-month old LRRK2 knockout rats and expand the analysis to demonstrate that the renal and possibly lung and liver abnormalities progress with age. The characterization of LRRK2 knockout rats may prove to be extremely valuable in understanding potential safety liabilities of LRRK2 kinase inhibitor therapeutics for treating Parkinson's disease.
Journal Article
Acute and Chronic Kidney Injury in a Non-Human Primate Model of Partial-Body Irradiation with Bone Marrow Sparing
The development of medical countermeasures against acute and delayed multi-organ injury requires animal models predictive of the human response to radiation and its treatment. Late chronic injury is a well-known feature of radiation nephropathy, but acute kidney injury has not been reported in an appropriate animal model. We have established a single-fraction partial-body irradiation model with minimal marrow sparing in non-human primates. Subject-based medical management was used including parenteral fluids according to prospective morbidity criteria. We show herein that 10 or 11 Gy exposures caused both acute and chronic kidney injury. Acute and chronic kidney injury appear to be dose-independent between 10 and 11 Gy. Acute kidney injury was identified during the first 50 days postirradiation and appeared to resolve before the occurrence of chronic kidney injury, which was progressively more severe up to 180 days postirradiation, which was the end of the study. These findings show that mitigation of the acute radiation syndrome by medical management will unmask delayed late effects that occur months after partial-body irradiation. They further emphasize that both acute and chronic changes in kidney function must be taken into account in the use and timing of mitigators and medical management for acute radiation syndrome and delayed effects of acute radiation exposure (DEARE).
Journal Article
MALDI-MSI spatially maps N-glycan alterations to histologically distinct pulmonary pathologies following irradiation
Radiation-induced lung injury is a highly complex combination of pathological alterations that develop over time and severity of disease development is dose-dependent. Following exposures to lethal doses of irradiation, morbidity and mortality can occur due to a combination of edema, pneumonitis and fibrosis. Protein glycosylation has essential roles in a plethora of biological and immunological processes. Alterations in glycosylation profiles have been detected in diseases ranging from infection, inflammation and cancer. We utilized mass spectrometry imaging to spatially map N-glycans to distinct pathological alterations during the clinically latent period and at 180 days post-exposure to irradiation. Results identified alterations in a number of high mannose, hybrid and complex N-glycans that were localized to regions of mucus and alveolar-bronchiolar hyperplasia, proliferations of type 2 epithelial cells, accumulations of macrophages, edema and fibrosis. The glycosylation profiles indicate most alterations occur prior to the onset of clinical symptoms as a result of pathological manifestations. Alterations in five N-glycans were identified as a function of time post-exposure. Understanding the functional roles N-glycans play in the development of these pathologies, particularly in the accumulation of macrophages and their phenotype, may lead to new therapeutic avenues for the treatment of radiation-induced lung injury.
Journal Article
Rubber modification of low temperature cure cyanate ester matrices and the performance in glass fabric composites
Low temperature cure cyanate ester resin systems were developed and modified with epoxy‐terminated butadiene acrylonitrile rubber (ETBN) and impregnated into woven glass fabric. Mode I and mode II interlaminar fracture toughness values of the cured laminates were evaluated as a function of rubber concentration. Mode I fracture toughness increased to almost twice that of the unmodified system, while mode II fracture toughness remained essentially unchanged. Composite samples were subjected to aging experiments in water and the absorption/desorption behavior was investigated as was the effect on thermal performance. The presence of rubber was found to reduce the rate of matrix deterioration but also caused a substantial increase in water uptake. It was found that although the addition of rubber to the matrices decreased the unconditioned (dry) Tg all specimens showed the same reduction in Tg, after equilibrium water absorption.
Journal Article
Looping Around Neutrino Charge Radius at Ultra-Near Reactor Experiments
We scrutinize the potential of upcoming ultra-near reactor neutrino experiments to detect radiative corrections in the elastic neutrino-electron scattering channel, focusing on the JUNO-TAO and CLOUD detectors, which employ advanced scintillator detection technologies. Previous reactor experiments have already constrained the electron neutrino charge radius, which is a neutrino property associated with a certain subset of the total radiative corrections, and have achieved limits that are only about an order of magnitude away from the Standard Model prediction. Our study demonstrates that JUNO-TAO and CLOUD could discover the neutrino charge radius in the near future, considering the established treatment of the charge radius. However, we show that it is necessary to go beyond this standard treatment. By including the complete set of one-loop level radiative corrections, we find a partial cancellation with the charge radius effect, reducing the experimental sensitivity to this quantity. Nevertheless, JUNO-TAO and CLOUD still have the potential to achieve a \\(5\\sigma\\) discovery but over longer timescales within a reasonable operational timeframe.
Paper
A LENS on DUNE-PRISM: Characterizing a Neutrino Beam with Off-Axis Measurements
Upcoming precision long-baseline neutrino oscillation experiments will be severely limited by the large systematic uncertainties associated with neutrino flux predictions and neutrino--nucleus cross sections. A promising remedy is the PRISM (Precision Reaction Independent Spectrum Measurement) technique, whereby the near detector measures the neutrino spectrum at different angles with respect to the beam axis. These measurements are then linearly combined into a prediction of the oscillated neutrino flux at the far detector. This prediction is data-driven, but still dependent on some theoretical knowledge about the neutrino flux. In this paper, we study to what extent off-axis measurements themselves can be used to directly constrain neutrino flux models. In particular, we use them to extract separately the fluxes and spectra of different meson species in the beam. We call this measurement LENS (Lateral Extraction of Neutrino Spectra). Second, we demonstrate how the thus improved flux model helps to further constrain the far detector flux prediction, thereby ultimately improving oscillation measurements.
Paper
Vanishing Acts: Quantifying Black Hole Formation with the DSNB Signal
The diffuse supernova neutrino background (DSNB) created by stellar core-collapses throughout cosmic history is on the verge of discovery, with SK-Gd showing early deviations from the background expectation and JUNO starting to take data. However, the interpretation of early DSNB data will face significant challenges due to degeneracies between astrophysical parameters and uncertainties in supernova neutrino modeling. We explore how complementary astronomical observations can break these degeneracies and, in this context, we investigate whether early DSNB observations can constrain invisible supernovae, which have no optical emission but are powerful neutrino sources before being swallowed by a forming black hole. Leveraging the differences in the spectra between invisible and visible supernovae, we estimate the sensitivity of 1) detecting the existence of invisible supernovae, and 2) determining the fraction of invisible supernovae. Finally, we discuss how these conclusions depend on the spectral parameters of the black hole-forming component.
Paper
Neutrino Theory in the Precision Era
This document summarises discussions on future directions in theoretical neutrino physics, which are the outcome of a neutrino theory workshop held at CERN in February 2025. The starting point is the realisation that neutrino physics offers unique opportunities to address some of the most fundamental questions in physics. This motivates a vigorous experimental programme which the theory community fully supports. \\textbf{A strong effort in theoretical neutrino physics is paramount to optimally take advantage of upcoming neutrino experiments and to explore the synergies with other areas of particle, astroparticle, and nuclear physics, as well as cosmology.} Progress on the theory side has the potential to significantly boost the physics reach of experiments, as well as go well beyond their original scope. Strong collaboration between theory and experiment is essential in the precision era. To foster such collaboration, \\textbf{we propose to establish a CERN Neutrino Physics Centre.} Taking inspiration from the highly successful LHC Physics Center at Fermilab, the CERN Neutrino Physics Centre would be the European hub of the neutrino community, covering experimental and theoretical activities.
Paper