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Institutions around the world are fighting to improve science communication all the time. From calls for journal papers to be simplified to encouraging scientists to take more of an active role through community engagement, there is an impetus to demystify and improve public understanding and engagement with science. Technology has greatly helped expand the range of learning styles that a lecturer can call on to reach people in new ways. Social media outlets like Twitter, Facebook, Instagram, and Tumblr have expanded the reach of science communication within and across scientific disciplines and to the lay public. Here, with all the videos, interactive quizzes, and instant feedback it can be easy to overlook one of the simplest methods for communicating complex ideas: comics.

The diameter of long-period fiber gratings (LPFGs) fabricated in optical fibers with a low cutoff wavelength was be reduced by hydrofluoric acid etching, enhancing the sensitivity to refractive index by more than a factor of 3, to 2611 nm/refractive index unit in the range from 1.333 to 1.4278. The grating period selected for the LPFGs allowed access to the dispersion turning point at wavelengths close to the visible range of the optical spectrum, where optical equipment is less expensive. As an example of an application, a pH sensor based on the deposition of a polymeric coating was analyzed in two situations: with an LPFG without diameter reduction and with an LPFG with diameter reduction. Again, a sensitivity increase of a factor of near 3 was obtained, demonstrating the ability of this method to enhance the sensitivity of thin-film-coated LPFG chemical sensors.

A long period grating (LPG) modified with a mesoporous film infused with a calixarene as a functional compound was employed for the detection of individual volatile organic compounds (VOCs) and their mixtures. The mesoporous film consisted of an inorganic part, SiO2 nanoparticles (NPs), along with an organic moiety of poly(allylamine hydrochloride) polycation PAH, which was finally infused with the functional compound, p-sulphanato calix[4]arene (CA[4]) or p-sulphanato calix[8]arene (CA[8]). The LPG sensor was designed to operate at the phase matching turning point to provide the highest sensitivity. The sensing mechanism is based on the measurement of the refractive index (RI) change induced by a complex of the VOCs with calixarene. The LPG, modified with a coating of 5 cycles of (SiO2 NPs/PAH) and infused with CA[4] or CA[8], was exposed to chloroform, benzene, toluene and acetone vapours. The British Standards test of the VOCs emissions from material (BS EN ISO 16000-9:2006) was used to test the LPG sensor performance.

In patients with suspected acute coronary syndrome (ACS), troponin testing is effective for diagnosis and prognosis. Troponin testing has now expanded to include patients without suspected ACS. This nonselective troponin testing has unknown consequences for resource utilization and outcome. Therefore, we examined selective versus nonselective troponin testing with respect to patient characteristics, resource utilization, and outcome. This retrospective 1-year study included all patients with troponin testing at a U.S. emergency department. Testing was classified as selective (ACS) or nonselective (non-ACS) based on admission ICD-9 codes. Troponin upper reference limit (URL) was ≥99th percentile. Among 47,053 patients, troponin was measured in 9109 (19%) of whom 5764 were hospitalized. Admission diagnosis was non-ACS in 4427 (77%) and ACS in 1337 (23%). Non-ACS patients were older, 71±17 versus 65±16 years, with longer hospital stay, 77 versus 32 h, and greater 1-year mortality 22% versus 6.7%; P<.001. In patients with troponin ≥URL, revascularization was performed in 64 (4.7%) of non-ACS versus 213 (48%) of ACS; P<.001. In patients with troponin 80% of the non-ACS population Contemporary troponin testing is frequently nonselective. The non-ACS and ACS populations differ significantly regarding clinical characteristics, revascularization rates, and outcomes. Troponin elevation is a powerful predictor of 1-year mortality in non-ACS, this association reveals an opportunity for risk stratification and targeted therapy. In patients with suspected acute coronary syndrome (ACS), troponin testing is effective for diagnosis and prognosis. However, troponin testing has now expanded to include patients without suspected ACS. This nonselective troponin testing has unknown consequences for hospital resource utilization and patient outcome. Our findings demonstrate contemporary troponin testing is largely nonselective (77% of testing was performed in patients without acute coronary syndrome). In comparison to patients with acute coronary syndrome, those with non-acute coronary syndrome are older, with longer hospital stay, lower revascularization rates, and greater 1-year mortality. Troponin elevation identifies a high-risk population in both acute coronary syndrome and non-acute coronary syndrome populations, yet effective treatment for the latter is lacking.

The intrinsic stability of fibre optic based sensing systems offer a platform that is suited to hazardous waste detection in a wide range of environments. Over the last few years Cranfield University has been working on the development of chemical sensors using optical fibres in combination with a group of chemical recognition molecules called calixarenes. Calixarenes semi-selectively with a range of solvents of interest makes them useful for chemical detection systems. This work has primarily been focused on the use of calixarenes in sensing benzene and other hazardous solvents. However, this approach could potentially be expanded for use in a wide range of chemical and even biological recognition systems. The initial aim of this project was to build on the previous work in fibre optic sensing at Cranfield and explore approaches to improve and extend the performance of the sensor system. The project first focused on improving the techniques used in the Langmuir-Blodgett (LB) deposition of calixarenes. Initial studies in this area highlighted one critical experimental error associated with the use of dry Wilhelmy plates to monitor the surface pressure of the Langmuir film. Dry filter paper plates take up to 2 hours to give stable data, with a drift of up to 10% in the measured surface pressure. It is shown that this problem can be avoided by using pre-soaked plates. To provide an alternative to the Wilhelmy plate surface pressure senor, an optical fibre surface pressure sensor was developed, measuring changes in the meniscus forming properties of a liquid. The sensor consists of a tapered single mode silica fibre, mounted with a small curvature and positioned with the tapered region of the fibre immersed in the water. The performance of the fibre optic sensor is comparable with that of the conventional Wilhelmy plate surface pressure sensor showing linearity of greater than 0.9. Following the analysis of the experimental systems used in the construction of the sensors, the project then focused on the chemistry of the materials and their suitability for LB coating. A variety of these materials were spread as Langmuir monolayers and their behavior upon compression measured. Long chain-substituted resorcinarenes gave more stable monolayers than their short chain analogues. The incorporation of long chain surfactants led to large increases in surface area, demonstrating that both resorcinarenes and surfactants are located at the water surface, except for one system where a bilayer structure is potentially formed. Further work on the behavior of the materials involved the alteration of the dipole-dipole interaction of the monolayer materials with the subphase. The modification of this interaction through the introduction of dipole altering additives, including alcohols and hydrogen peroxide, to the aqueous subphase was investigated. The resulting isotherms of the materials showed a reduction in the surface pressure and area per molecule required in order for the monolayer to reach its point of collapse. This ability to shift the point of collapse has application in the optimisation of Langmuir-Blodgett coating of surfaces. Within this project the sensing properties of a fibre sensor were also modelled extensively in order to determine the theoretical sensing limits of a fibre optic vapour sensor. The model showed that the sensing goals of 1ppm originally envisaged for this project were unobtainable due to the low number of gas molecules interacting with the sensor. However, this led to the proposal of a new application of the system in sensing contaminants in water, where the same limitations would not apply. The results for the sensor system tested in water show how significantly more sensitive the system is to toluene contamination in water than it is to toluene vapour. These results demonstrate the utility of the developed system for many pollutant-sensing applications, include crude oil detection.

In an attempt to understand the multiple lives of an object - specifically a death inquest register from the year 1976 - this dissertation examines five moments in the objects life (referred to as the Ledger) that invest it with ‘capital’. They are;• The Cillié Commission of Inquiry.• Sam Nzima’s photograph of Hector Pieterson.• The destruction of apartheid documents in the early 1990’s. • Kendell Geers’ appropriation of the Ledger.• Museum Africa’s purchase of the Ledger.By applying a biographical methodology to this object, this dissertation examines how the shifts in the multiple lives of the Ledger address the different roles that the archive plays in the construction of memory in South Africa.

The high tuition fees paid by overseas students are an attractive source of revenue in these straitened times. But will higher education reforms change all that?

UK universities are regularly exhorted to learn from the US, but we can teach them, too, writes Matthew Partridge