Catalogue Search | MBRL
Are you sure you want to remove the book from the shelf?
{{itemTitle}}
951
result(s) for
"Patterson, Christopher"
Sort by:
Middle school, the worst years of my life
When Rafe Kane enters middle school, he teams up with his best friend, \"Leo the Silent,\" to create a game to make school more fun by trying to break every rule in the school's code of conduct.
Book
Type 1 diabetes in 2017: global estimates of incident and prevalent cases in children and adults
Aims/hypothesisData on type 1 diabetes incidence and prevalence are limited, particularly for adults. This study aims to estimate global numbers of incident and prevalent cases of type 1 diabetes in 2017 for all age groups, by country and areas defined by income and region.MethodsIncidence rates of type 1 diabetes in children (available from 94 countries) from the IDF Atlas were used and extrapolated to countries without data. Age-specific incidence rates in adults (only known across full age range for fewer than ten countries) were obtained by applying scaling ratios for each adult age group relative to the incidence rate in children. Age-specific incidence rates were applied to population estimates to obtain incident case numbers. Duration of diabetes was estimated from available data and adjusted using differences in childhood mortality rate between countries from United Nations demographic data. Prevalent case numbers were derived by modelling the relationship between prevalence, incidence and disease duration. Sensitivity analyses were performed to quantify the impact of alternative assumptions and model inputs.ResultsGlobal numbers of incident and prevalent cases of type 1 diabetes were estimated to be 234,710 and 9,004,610, respectively, in 2017. High-income countries, with 17% of the global population, accounted for 49% of global incident cases and 52% of prevalent cases. Asia, which has the largest proportion of the world’s population (60%), had the largest number of incident (32%) and prevalent (31%) cases of type 1 diabetes. Globally, 6%, 35%, 43% and 16% of prevalent cases were in the age groups 0–14, 15–39, 40–64 and 65+ years, respectively. Based on sensitivity analyses, the estimates could deviate by ±15%.Conclusions/interpretationGlobally, type 1 diabetes represents about 2% of the estimated total cases of diabetes, ranging from less than 1% in certain Pacific countries to more than 15% in Northern European populations in 2017. This study provides information for the development of healthcare and policy approaches to manage type 1 diabetes. The estimates need further validation due to limitations and assumptions related to data availability and estimation methods.
Journal Article
Born to rock
When her favorite rock band Lulu and the Handbags announces a contest, Georgia is determined the all-girl rock band she is in will win--even if she has to ask her brother Rafe for help.
Book
Incidence trends for childhood type 1 diabetes in Europe during 1989–2003 and predicted new cases 2005–20: a multicentre prospective registration study
The incidence of type 1 diabetes in children younger than 15 years is increasing. Prediction of future incidence of this disease will enable adequate fund allocation for delivery of care to be planned. We aimed to establish 15-year incidence trends for childhood type 1 diabetes in European centres, and thereby predict the future burden of childhood diabetes in Europe.
20 population-based EURODIAB registers in 17 countries registered 29 311 new cases of type 1 diabetes, diagnosed in children before their 15th birthday during a 15-year period, 1989–2003. Age-specific log linear rates of increase were estimated in five geographical regions, and used in conjunction with published incidence rates and population projections to predict numbers of new cases throughout Europe in 2005, 2010, 2015, and 2020.
Ascertainment was better than 90% in most registers. All but two registers showed significant yearly increases in incidence, ranging from 0·6% to 9·3%. The overall annual increase was 3·9% (95% CI 3·6–4·2), and the increases in the age groups 0–4 years, 5–9 years, and 10–14 years were 5·4% (4·8–6·1), 4·3% (3·8–4·8), and 2·9% (2·5–3·3), respectively. The number of new cases in Europe in 2005 is estimated as 15 000, divided between the 0–4 year, 5–9 year, and 10–14 year age-groups in the ratio 24%, 35%, and 41%, respectively. In 2020, the predicted number of new cases is 24 400, with a doubling in numbers in children younger than 5 years and a more even distribution across age-groups than at present (29%, 37%, and 34%, respectively). Prevalence under age 15 years is predicted to rise from 94 000 in 2005, to 160 000 in 2020.
If present trends continue, doubling of new cases of type 1 diabetes in European children younger than 5 years is predicted between 2005 and 2020, and prevalent cases younger than 15 years will rise by 70%. Adequate health-care resources to meet these children's needs should be made available.
European Community Concerted Action Program.
Journal Article
Get me out of here!
After surviving sixth grade, Rafe expects seventh grade to be a fun zone because he's been accepted to art school in the big city, but when he discovers it's more competitive than he expected, he sets out to turn his boring life into the inspiration for a work of art.
Book
Ibrutinib in Previously Treated Waldenström’s Macroglobulinemia
In a study conducted at three institutions, ibrutinib was associated with major responses in 73% of patients with Waldenström's macroglobulinemia who had received at least one previous treatment. Toxic effects of grade 2 or higher included neutropenia in 22% of the patients.
Waldenström’s macroglobulinemia is a malignant B-cell lymphoma that is associated with an accumulation of clonal lymphoplasmacytic cells and monoclonal IgM secretion.
1
Despite advances in treatment, the disease eventually progresses in most patients, and new treatment options are needed.
Whole-genome sequencing has revealed a single activating somatic mutation in
MYD88
(resulting in a predicted protein change from leucine to proline at amino acid position 265) and multiple activating mutations in the C-terminal domain of
CXCR4
in patients with Waldenström’s macroglobulinemia.
2
,
3
In tumor cells, MYD88L265P triggers activation of nuclear factor κB (NF-κB) through two divergent pathways involving Bruton’s tyrosine kinase (BTK) . . .
Journal Article
From hero to zero
\"Rafe Khatchadorian takes his troublemaking ways across the pond and gets lost in London\"-- Provided by publisher.
Book
Understanding health literacy in men: a cross-sectional survey
Background
Males have a shorter life expectancy than females. Men are less likely to seek the advice of a health professional or utilise preventive health services and programs. This study seeks to explore health literacy and the characteristics affecting this among Australian men.
Methods
Four hundred and thirty-one adult males engaged with the New South Wales Rural Fire Service, completed an online cross-sectional survey, undertaken from September – November 2022. The survey tool captured demographic data, health status and lifestyle risk characteristics. Health literacy was measured using the 44-item Health Literacy Questionnaire (HLQ). Descriptive statistics, frequencies, percentages, means and standard deviations, were used to describe the sample. Interferential statistics, including the Mann-Whitney U Test and the Kruskal-Wallis Test, were used to explore differences between demographics and HLQ scales.
Results
For the first 5 scales (4-point Likert scale), the lowest score was seen for ‘
Appraisal of health information
’ (Mean 2.81; SD 0.52) and the highest score was seen for ‘
Feeling understood and supported by healthcare providers ’
(
Mean
3.08; SD 0.64). For the other 4 scales (5-point Likert scale), the lowest score was seen for
‘Navigating the healthcare system’
(Mean 3.74; SD 0.69). The highest score was seen for
‘Understand health information well enough to know what to do’
(Mean 4.10; SD 0.53). Age, income level and living in an urban/rural location were significantly related to health literacy scales.
Conclusions
This study provides new insight into men’s health literacy and the factors impacting it. This knowledge can inform future strategies to promote men’s engagement with health services and preventive care.
Journal Article
The 13-minute murder : thrillers
Dead man running: \"Psychiatrist Randall Beck specializes in PTSD cases--and his time is limited. Especially when he uncovers a plot to kill a presidential candidate\"-- Provided by publisher.
BOOK
MYD88 L265P Somatic Mutation in Waldenström's Macroglobulinemia
Waldenström's macroglobulinemia is a lymphoplasmacytic lymphoma. Genetic analysis has revealed a common mutation (L265P) in
MYD88
in more than 90% of patients with this disease. The mutation appears to activate NF-κB.
Waldenström's macroglobulinemia is an IgM-secreting lymphoplasmacytic lymphoma (LPL).
1
,
2
Clinical manifestations of Waldenström's macroglobulinemia include cytopenia resulting from bone marrow infiltration by lymphoplasmacytic cells, paraprotein-related cryoglobulinemia, the cold agglutinin syndrome, demyelinating neuropathy, and symptomatic hyperviscosity.
3
The oncogenic basis of Waldenström's macroglobulinemia has not been defined. Familial clustering of Waldenström's macroglobulinemia and other B-cell disorders suggests that genetic factors play a role in the pathogenesis of Waldenström's macroglobulinemia in certain patients.
4
–
6
IgM monoclonal gammopathy of unknown significance (MGUS) is characterized by the presence of a monoclonal IgM protein and the absence of bone marrow disease involvement on histologic examination.
1
IgM . . .
Journal Article