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This dissertation explores lusophone soundscapes in Lisbon in synchronic and diachronic perspectives. It focuses on the governance of a music festival in the capital of Portugal: Musidanças, organized by the Portuguese-Angolan musician Firmino Pascoal since 2001. It relates cultural agents that have evoked the ambivalent notion of lusofonia. Drawing from in loco and virtual fieldwork, I analyze musical webs of interest into play in contexts of lusophone fluidity, and seek to understand how local music producers and their products represent lusofonia in festive events, other venues and recordings. I point out ways in which Firmino Pascoal has voiced national provenances of musicians and music categories performed. Although existing studies mention historical references of intercultural mixture, only recently related taboos are approached. This Ethnomusicology study case of Musidanças, implying strategies of Discourse Analysis unveils relations between music and social change, thinks beyond narratives of origins and focuses on representations of intercultural awareness and intervention.

\"Tommy Smith, Iraq War vet and former Eastern Sierra wilderness guide, is home from war after re-upping for a tour in Afghanistan. When his old friend Dave Cathcart disappears from his ranch, Tommy answers the call to help find him. What he learns is that his love for Dave's daughter, his old flame Sarah Cathcart, never died, but the country where he grew up is undergoing change. When Sarah confides that her husband, a smooth-talking entrepreneur, has lost her trust and may not be all he seems, Tommy begins to investigate. Soon another disappearance leads to a gruesome discovery, and a brutal sequence of events takes Sarah and Tommy to old haunts in the high country, where once again he will need to call on his sniper's skills to save them both and to rescue her missing father\"-- Provided by publisher.

Liver X Receptors (LXRs) are nuclear hormone receptors that regulate key genes involved in cholesterol and lipid metabolism. As transcription factors, LXRs turn on the gene expression of ATP-binding cassette transporters (ABCs) which mediate cholesterol efflux from cells, such as macrophage foam cells. In addition, LXRs have the ability to down regulate pro-inflammatory genes. Therefore, LXRs have been extensively investigated as potential therapeutic targets for the treatment of conditions that result from altered cholesterol and lipid homeostasis as well as increased inflammation, such as atherosclerosis and Alzheimer's disease (AD). This latter is a neurodegenerative disorder that is associated with the deposition of brain amyloid plaques, constituted by insoluble Aβ peptides. LXR activation has been shown to promote Aβ clearance from the brain via the ABCA1-apolipoprotein E pathway and improve cognitive functions in rodent models of AD. The ability of LXRs to promote reverse cholesterol transport (RCT) and suppress inflammation has been characterized in both human and murine in vitro systems, but mostly in rodent in vivo systems. Although the LXR signaling pathway is mostly conserved across species, LXRs can also regulate their target genes in a species-, tissue- and isoform-specific fashion. Therefore the purpose of this work is to investigate the regulation of target genes by LXRs across species and identify, if any, differences that could aid us in understanding the role of LXR modulation in higher species, such as non-human primates. In the context of inflammation, the LXR genome landscape had only been investigated in murine macrophages. Therefore, we performed a genome-wide screen in human THP-1 macrophages. This led us to the identification of a novel LXR target gene, Sphingomyelin Phosphodiesterase Acid-Like 3A Gene (SMPDL3A), which is regulated in a species- and tissue-specific fashion, being restricted to human blood cells, with no induction by LXRs in mouse cellular systems. Next, we confirmed the LXR-mediated upregulation of ABCA1 and ApoE genes in Cynomolgus monkey brains, as this had never been investigated in higher species. In addition, we also characterized the LXR transcriptome in Cynomolgus brain by RNA-sequencing in order to identify potential novel LXR target genes. For the first time in higher species, we show Apolipoprotein AI upregulation in the brain of Cynomolgus monkey upon treatment with a synthetic LXR modulator.

This dissertation explores the concept of lusofonia. Departing from a discursive analysis of the concept, I will address the ways through which it figures in the cultural policies of the Municipality of Lisbon and of governmental institutions, and how it informs their actions. I will also explore the role of voluntary associations such as Sons da Lusofonia that evoke lusofonia as part of their goals. I will then analyze how the concept of lusofoniaand the action of governmental institutions and voluntary associations inform the creative work and identities of selected Portuguese-speaking migrant musicians from the PALOP (African Portuguese-speaking countries), Brazil and East Timor.Esta dissertação aborda o conceito de lusofonia. Partindo de uma análise discursiva do conceito, abordarei os modos através dos quais este conceito figura nas políticas culturais da Câmara Municipal de Lisboa e das instituições governamentais, e como é que informa as suas acções. A dissertação explora igualmente o papel de associações voluntárias como Sons da Lusofonia ancorados no conceito de lusofonia. Este trabalho analisa os modos através dos quais o conceito de lusofoniae a acção das instituições governamentais e associações voluntárias enformam o trabalho criativo e as identidades de alguns músicos migrantes dos PALOP (Países Africanos de Língua Portuguesa), Brasil e Timor Leste.

Calvinism's influence and reputation have received ample scholarly attention. But how John Calvin himself - his person, character, and deeds - was remembered, commemorated, and memorialized, is a question few historians have addressed. Focussing on the nineteenth and twentieth centuries, this volume aims to open up the subject with chapters on Calvin's monumentalization in statues and museums, his appearance in novels, children's books, and travel writing, his iconic function for Hungarian nationalists and Presbyterian missionaries to China, his reputation among Mormons and freethinkers, and his rivalry with Michael Servetus in French Protestant memory. The result is a fresh contribution to the field of religious memory studies and an invitation to further comparative research.Contributors include: R. Bryan Bademan, Patrick Cabanel, R. Scott Clark, Thomas J. Davis, Stephen S. Francis, Joe B. Fulton, Botond Gaál, Stefan Laube, Johan de Niet, Herman Paul, James Rigney, Michèle Sacquin, Jonathan Seitz, Robert Vosloo, Bart Wallet, and Valentine Zuber.

The differential cross section for two-body deuteron photodisintegration was measured at photon energies between 0.8 and 4.0 GeV and center-of-mass angles [special characters omitted] = 37°, 53°, 70°, and 90° as part of CEBAF experiment E89-012. Constituent counting rules predict a scaling of this cross section at asymptotic energies. In previous experiments this scaling has surprisingly been observed at energies between 1.4 and 2.8 GeV at 90°. The results from this experiment are in reasonable agreement with previous measurements at lower energies. The data at 70° and 90° show a Constituent counting rule behavior up to 4.0 GeV photon energy. The 37° and 53° data do not agree with the constituent counting rule prediction. The new data are compared with a variety of theoretical models inspired by quantum chromodynamics (QCD) and traditional hadronic nuclear physics.

Ushering in a new era of work In a recent survey conducted by Gartner in December 2020, 90% of companies plan to allow employees to work remotely at least part of the time, even after the COVID-19 vaccine is widely adopted. 65% of respondents reported that their organization will continue to offer employees flexibility on when and where they work by offering the technical infrastructure to support internal and external collaboration, and the data insights that give leadership teams the confidence to adapt policies with agility. [...]a hybrid model is likely to emerge, balancing the benefits of remote work with the benefits of social interactions, as well as the creativity and innovation produced by working with others in person. [...]leaders must ensure that data literacy training, which can be done both in the workplace and at home, is a key component of their organization's data strategy, with these employees encouraged to ask questions about converting data into a better output.

In three experiments, young and old subjects were required to make either identity judgements or parity (left-right orientation) judgements to line drawings of common objects or nonsense objects. The effects of angle of misorientation and figural complexity on reaction times were examined. Performance patterns suggested that distinct processes underlie the two types of judgements and that aging differentially affects these processes.