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The Language Difference
Language is a sensitive issue in the developing world, because language choice and behaviour are integral to the social, economic and political stability of multicultural societies. To what extent does this argument hold? Does language make a difference when it comes to development, and is there a perceptible difference in development between countries that is attributable to their choice of language? This book sets out to answer these questions by investigating how language has been and is being used in four countries of the Greater Mekong Sub-region (i.e. Cambodia, the Lao PDR, Myanmar and Viet Nam), especially in the critical areas of education, health, the economy and governance.
eBook
Democracy's slaves : a political history of ancient Greece
The toga-clad statesman of ancient Greece is a familiar figure in the Western political tradition. Less well known is the administrator who ran the state but who was himself a slave. Challenging the modern belief that democracy and bondage are incompatible, Paulin Ismard directs our attention to the cradle of Western democracy, ancient Athens, where the functioning of civic government depended crucially on highly skilled experts who were literally public servants--slaves owned by the city-state rather than by private citizens. Known as demosioi, these public slaves filled a variety of important roles in Athenian society. They were court clerks, archivists, administrators, accountants, and policemen. Many possessed knowledge and skills beyond the attainments of average citizens, and they enjoyed privileges, such as the right to own property, that were denied to private slaves. In effect, demosioi were Western civilization's first civil servants--though they carried out their duties in a condition of bound servitude. Ismard detects a radical split between politics and administrative government at the heart of Athenian democracy. The city-state's managerial caste freed citizens from the day-to-day responsibilities of running the state. By the same token, these public servants were unable to participate in the democratic process because they lacked the rights of full citizenship. By rendering the state's administrators politically invisible, Athens warded off the specter of a government capable of turning against the citizens' will. In a real sense, Ismard shows, Athenian citizens put the success of their democratic experiment in the hands of slaves.-- Provided by publisher
Book
Side effects of pain and analgesia in animal experimentation
This review highlights selected effects of untreated pain and of widely used analgesics such as opioids, non-steroid anti-inflammatory drugs and antipyretics, to illustrate the relevance of carefully planned, appropriate and controlled analgesia for greater reproducibility in animal experiments involving laboratory rodents.
Journal Article
Mortality due to cancer treatment delay: systematic review and meta-analysis
AbstractObjectiveTo quantify the association of cancer treatment delay and mortality for each four week increase in delay to inform cancer treatment pathways.DesignSystematic review and meta-analysis.Data sourcesPublished studies in Medline from 1 January 2000 to 10 April 2020.Eligibility criteria for selecting studiesCurative, neoadjuvant, and adjuvant indications for surgery, systemic treatment, or radiotherapy for cancers of the bladder, breast, colon, rectum, lung, cervix, and head and neck were included. The main outcome measure was the hazard ratio for overall survival for each four week delay for each indication. Delay was measured from diagnosis to first treatment, or from the completion of one treatment to the start of the next. The primary analysis only included high validity studies controlling for major prognostic factors. Hazard ratios were assumed to be log linear in relation to overall survival and were converted to an effect for each four week delay. Pooled effects were estimated using DerSimonian and Laird random effect models.ResultsThe review included 34 studies for 17 indications (n=1 272 681 patients). No high validity data were found for five of the radiotherapy indications or for cervical cancer surgery. The association between delay and increased mortality was significant (P<0.05) for 13 of 17 indications. Surgery findings were consistent, with a mortality risk for each four week delay of 1.06-1.08 (eg, colectomy 1.06, 95% confidence interval 1.01 to 1.12; breast surgery 1.08, 1.03 to 1.13). Estimates for systemic treatment varied (hazard ratio range 1.01-1.28). Radiotherapy estimates were for radical radiotherapy for head and neck cancer (hazard ratio 1.09, 95% confidence interval 1.05 to 1.14), adjuvant radiotherapy after breast conserving surgery (0.98, 0.88 to 1.09), and cervix cancer adjuvant radiotherapy (1.23, 1.00 to 1.50). A sensitivity analysis of studies that had been excluded because of lack of information on comorbidities or functional status did not change the findings.ConclusionsCancer treatment delay is a problem in health systems worldwide. The impact of delay on mortality can now be quantified for prioritisation and modelling. Even a four week delay of cancer treatment is associated with increased mortality across surgical, systemic treatment, and radiotherapy indications for seven cancers. Policies focused on minimising system level delays to cancer treatment initiation could improve population level survival outcomes.
Journal Article
Exploring the Convergence of Cybersecurity, Fintech and Artificial General Intelligence: Innovations and Implications
The convergence of cybersecurity, financial technology (fintech) and artificial general intelligence (AGI) signifies a major transformation in how digital financial ecosystems operate and are protected. This article critically examines the intersections of these domains and their effects on risk detection, data governance and the delivery of financial services. By synthesising existing literature, empirical data and case-based insights, the study investigates the opportunities and threats arising from the integration of AGI into fintech environments. It also evaluates the effectiveness of current cybersecurity strategies in addressing algorithmic threats and regulatory gaps. The findings indicate that while AGI enhances operational efficiency and threat detection, it also introduces new ethical, technical and governance challenges. This study provides a framework for navigating these complexities and urges stakeholders to adopt adaptive regulatory strategies and interdisciplinary collaboration to ensure security, innovation and trust in the digital financial ecosystem era.
Journal Article
Six Key Advantages and Disadvantages of Working from Home in Europe during COVID-19
The number of people working from home (WFH) increased radically during the coronavirus (COVID-19) pandemic. The purpose of this study was therefore to investigate people’s experiences of WFH during the pandemic and to identify the main factors of advantages and disadvantages of WFH. Data from 29 European countries on the experiences of knowledge workers (N = 5748) WFH during the early stages of lockdown (11 March to 8 May 2020) were collected. A factor analysis showed the overall distribution of people’s experiences and how the advantages and disadvantages of WFH during the early weeks of the pandemic can be grouped into six key factors. The results indicated that most people had a more positive rather than negative experience of WFH during lockdown. Three factors represent the main advantages of WFH: (i) work–life balance, (ii) improved work efficiency and (iii) greater work control. The main disadvantages were (iv) home office constraints, (v) work uncertainties and (vi) inadequate tools. Comparing gender, number of children at home, age and managers versus employees in relation to these factors provided insights into the differential impact of WFH on people’s lives. The factors help organisations understand where action is most needed to safeguard both performance and well-being. As the data were collected amidst the COVID-19 pandemic, we recommend further studies to validate the six factors and investigate their importance for well-being and performance in knowledge work.
Journal Article
Nucleobase and Nucleoside Analogues: Resistance and Re-Sensitisation at the Level of Pharmacokinetics, Pharmacodynamics and Metabolism
Antimetabolites, in particular nucleobase and nucleoside analogues, are cytotoxic drugs that, starting from the small field of paediatric oncology, in combination with other chemotherapeutics, have revolutionised clinical oncology and transformed cancer into a curable disease. However, even though combination chemotherapy, together with radiation, surgery and immunotherapy, can nowadays cure almost all types of cancer, we still fail to achieve this for a substantial proportion of patients. The understanding of differences in metabolism, pharmacokinetics, pharmacodynamics, and tumour biology between patients that can be cured and patients that cannot, builds the scientific basis for rational therapy improvements. Here, we summarise current knowledge of how tumour-specific and patient-specific factors can dictate resistance to nucleobase/nucleoside analogues, and which strategies of re-sensitisation exist. We revisit well-established hurdles to treatment efficacy, like the blood-brain barrier and reduced deoxycytidine kinase activity, but will also discuss the role of novel resistance factors, such as SAMHD1. A comprehensive appreciation of the complex mechanisms that underpin the failure of chemotherapy will hopefully inform future strategies of personalised medicine.
Journal Article
The Antimicrobial Activity of Cannabinoids
A post-antibiotic world is fast becoming a reality, given the rapid emergence of pathogens that are resistant to current drugs. Therefore, there is an urgent need to discover new classes of potent antimicrobial agents with novel modes of action. Cannabis sativa is an herbaceous plant that has been used for millennia for medicinal and recreational purposes. Its bioactivity is largely due to a class of compounds known as cannabinoids. Recently, these natural products and their analogs have been screened for their antimicrobial properties, in the quest to discover new anti-infective agents. This paper seeks to review the research to date on cannabinoids in this context, including an analysis of structure–activity relationships. It is hoped that it will stimulate further interest in this important issue.
Journal Article