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Background Observational studies have suggested a suspected association between gastroesophageal reflux disease (GERD) and respiratory diseases, but the causality remains equivocal. The goal of this study was to evaluate the causal role of GERD in respiratory diseases by employing Mendelian randomization (MR) studies. Methods We conducted Mendelian randomization analysis based on summary data of genome-wide association studies (GWASs) and three MR statistical techniques (inverse variance weighted, weighted median and MR-Egger) were employed to assess the probable causal relationship between GERD and the risk of respiratory diseases. Sensitivity analysis was also carried out to ensure more trustworthy results, which involves examining the heterogeneity, pleiotropy and leave-one-SNP-out method. We also identified 33 relevant genes and explored their distribution in 26 normal tissues. Results In the analysis, for every unit increase in developing GERD, the odds ratio for developing COPD, bronchitis, pneumonia, lung cancer and pulmonary embolism rose by 72% (OR IVW  = 1.72, 95% CI 1.50; 1.99), 19% (OR IVW  = 1.19, 95% CI 1.11; 1.28), 16% (OR IVW  = 1.16, 95% CI 1.07; 1.26), 0. 3% (OR IVW  = 1.003, 95% CI 1.0012; 1.0043) and 33% (OR IVW  = 1.33, 95% CI 1.12; 1.58), respectively, in comparison with non-GERD cases. In addition, neither heterogeneity nor pleiotropy was found in the study. This study also found that gene expression was higher in the central nervous system and brain tissue than in other normal tissues. Conclusions This study provided evidence that people who developed GERD had a higher risk of developing COPD, bronchitis, pneumonia, lung cancer and pulmonary embolism. Our research suggests physicians to give effective treatments for GERD on respiratory diseases. By exploring the gene expression, our study may also help to reveal the role played by the central nervous system and brain tissue in developing respiratory diseases caused by GERD.

This paper proposes a neural network based on the Markov probability transition matrix to predict the training performance of football athletes. Firstly, seven training indicators affecting the training performance are designed by the Event-group training theory. Then, a discrete Hopfield neural network is employed according to the seven training indicators. To improve the forecast ability of the discrete Hopfield neural network, the Markov probability transition matrix is used to calculate the activation probability of neurons. Finally, experimental results indicate that the proposed model defeats against the competitors in the forecast of training performance of football athletes. And the proposed model can find the major training indicators that have direct effects on the training performance, which can provide scientific suggestions for coaches to customize training plans. We demonstrate that the seven training indicators can sufficiently evaluate the effectiveness of training plans in the improvement in terms of training performance for football athletes.

Crop pests have a great impact on the quality and yield of crops. The use of deep learning for the identification of crop pests is important for crop precise management. To address the lack of data set and poor classification accuracy in current pest research, a large-scale pest data set named HQIP102 is built and the pest identification model named MADN is proposed. There are some problems with the IP102 large crop pest dataset, such as some pest categories are wrong and pest subjects are missing from the images. In this study, the IP102 data set was carefully filtered to obtain the HQIP102 data set, which contains 47,393 images of 102 pest classes on eight crops. The MADN model improves the representation capability of DenseNet in three aspects. Firstly, the Selective Kernel unit is introduced into the DenseNet model, which can adaptively adjust the size of the receptive field according to the input and capture target objects of different sizes more effectively. Secondly, in order to make the features obey a stable distribution, the Representative Batch Normalization module is used in the DenseNet model. In addition, adaptive selection of whether to activate neurons can improve the performance of the network, for which the ACON activation function is used in the DenseNet model. Finally, the MADN model is constituted by ensemble learning. Experimental results show that MADN achieved an accuracy and F1Score of 75.28% and 65.46% on the HQIP102 data set, an improvement of 5.17 percentage points and 5.20 percentage points compared to the pre-improvement DenseNet-121. Compared with ResNet-101, the accuracy and F1Score of MADN model improved by 10.48 percentage points and 10.56 percentage points, while the parameters size decreased by 35.37%. Deploying models to cloud servers with mobile application provides help in securing crop yield and quality.

Accurate and automated detection of diseases is crucial for sustainable strawberry production. However, the challenges posed by small size, mutual occlusion, and high intra-class variance of symptoms in complex agricultural environments make this difficult. Mainstream deep learning detectors often do not perform well under these demanding conditions. We propose a novel detection framework designed for superior accuracy and robustness to address this critical gap. Our framework introduces four key innovations: First, we propose a novel attention-driven detection head featuring our Parallel Pyramid Attention (PPA) module. Inspired by pyramid attention principles, our module’s unique parallel multi-branch architecture is designed to overcome the limitations of serial processing. It simultaneously integrates global, local, and serial features to generate a fine-grained attention map, significantly improving the model’s focus on targets of varying scales. Second, we enhance the core feature fusion blocks by integrating Monte Carlo Attention (MCAttn), effectively empowering the model to recognize targets across diverse scales. Third, to improve the feature representation capacity of the backbone without increasing the parametric overhead, we replace standard convolutions with Frequency-Dynamic Convolutions (FDConv). This approach constructs highly diverse kernels in the frequency domain. Finally, we employ the Scale-Decoupled Loss function to optimize training dynamics. By adaptively re-weighting the localization and scale losses based on target size, we stabilize the training process and improve the Precision of bounding box regression for small objects. Extensive experiments on a challenging dataset related to strawberry diseases demonstrate that our proposed model achieves a mean Average Precision (MAP) of 81.1%. This represents an improvement of 2.1% over the strong YOLOv12-n baseline, highlighting its practical value as an effective tool for intelligent disease protection.

This paper proposes PestNet, a lightweight method for classifying crop pests, which improves upon MobileNet-V2 to address the high model complexity and low classification accuracy commonly found in pest classification research. Firstly, the training phase employs the AdamW optimizer and mixup data augmentation techniques to enhance the model’s convergence and generalization capabilities. Secondly, the Adaptive Spatial Group-Wise Enhanced (ASGE) attention mechanism is introduced and integrated into the inverted residual blocks of the MobileNet-V2 model, boosting the model’s ability to extract both local and global pest information. Additionally, a dual-branch feature fusion module is developed using convolutional kernels of varying sizes to enhance classification performance for pests of different scales under real-world conditions. Lastly, the model’s activation function and overall architecture are optimized to reduce complexity. Experimental results on a proprietary pest dataset show that PestNet achieves classification accuracy and an F1 score of 87.62% and 86.90%, respectively, marking improvements of 4.20 percentage points and 5.86 percentage points over the baseline model. Moreover, PestNet’s parameter count and floating-point operations are reduced by 14.10% and 37.50%, respectively, compared to the baseline model. When compared with ResNet-50, MobileNet V3-Large, and EfficientNet-B1, PestNet offers superior parameter efficiency and floating-point operation requirements, as well as improved pest classification accuracy.

Studies have demonstrated that red blood cell distribution width (RDW) is closely associated with the prognosis of patients with chronic obstructive pulmonary disease (COPD). In addition, the dynamic changes in RDW appear to play an important role. Thus, we aimed to investigate the relationship between dynamic changes in RDW and 30-day all-cause readmission of patients with acute exacerbation of COPD (AECOPD). In this retrospective cohort study, we enrolled patients with AECOPD hospitalized in the Department of Respiratory Medicine in Liyuan Hospital (Wuhan China), a tertiary, university-affiliated, public hospital. Patients with AECOPD were divided into three groups based on their RDW values after the first and fourth days of admission. The normal range for RDW is 10-15%. Patients with normal RDW values were included in the normal group. Patients with an RDW value >15% on the first day, which subsequently decreased by >2% on the fourth day was included in the decreased group. The increased group was comprised of patients with an RDW value >15% on the first day which continued to increase, or those with a normal RDW value on the first day which increased >15% on the fourth day. A total of 239 patients (age: 72 years [range: 64-81 years]; male: n=199 [83.3%]) were included. There were 108, 72, and 59 patients in the RDW normal, decreased, and increased groups, respectively; the 30-day all-cause readmission rate was 9.3%, 9.7%, 27.1%, respectively; (p=0.003), being noticeably higher in the RDW increased group. Dynamic increase of RDW (OR:3.45, 95% CI: 1.39-8.58, p= 0.008) was independently correlated with 30-day all-cause readmission of patients with AECOPD. The dynamic increase of RDW is an independent prognostic factor of 30-day all-cause readmission of patients with AECOPD.

Machine learning and image processing have been combined to identify and detect defects in mature citrus fruit at night, which has great research and development significance. First, a multi-light vision system was used to collect citrus UV images, and from these, 1500 samples were obtained, 80% of which were training and 20% were experimental sets. For a support vector machine (SVM) model with “2*Cb-Cr”, “4*a-b-l”, and “H” as the training features, the accuracy of the final training model in the experimental set is 99.67%. Then, the SVM model was used to identify mature citrus regions, detect defects, and output the defective citrus regions label. The average running time of the detection algorithm was 0.84097 s, the accuracy of citrus region detection was 95.32%, the accuracy of citrus defect detection was 96.32%, the precision was 95.24%, and the recall rate was 87.91%. The results show that the algorithm had suitable accuracy and real-time performance in recognition and defect detection in citrus in a natural environment at night.

Red imported fire ants (RIFA) are an alien invasive pest that can cause serious ecosystem damage. Timely detection, location and elimination of RIFA nests can further control the spread of RIFA. In order to accurately locate the RIFA nests, this paper proposes an improved deep learning method of YOLOv4. The specific methods were as follows: 1) We improved GhostBottleNeck (GBN) and replaced the original CSP block of YOLOv4, so as to compress the network scale and reduce the consumption of computing resources. 2) An Efficient Channel Attention (ECA) mechanism was introduced into GBN to enhance the feature extraction ability of the model. 3) We used Equalized Focal Loss to reduce the loss value of background noise. 4) We increased and improved the upsampling operation of YOLOv4 to enhance the understanding of multi-layer semantic features to the whole network. 5) CutMix was added in the model training process to improve the model's ability to identify occluded objects. The parameters of improved YOLOv4 were greatly reduced, and the abilities to locate and extract edge features were enhanced. Meanwhile, we used an unmanned aerial vehicle (UAV) to collect images of RIFA nests with different heights and scenes, and we made the RIFA nests (RIFAN) airspace dataset. On the RIFAN dataset, through qualitative analysis of the evaluation indicators, mean average precision (MAP) of the improved YOLOv4 model reaches 99.26%, which is 5.9% higher than the original algorithm. Moreover, compared with Faster R-CNN, SSD and other algorithms, improved YOLOv4 has achieved excellent results. Finally, we transplanted the model to the embedded device Raspberry Pi 4B and assembled it on the UAV, using the model's lightweight and high-efficiency features to achieve flexible and fast flight detection of RIFA nests.

Images captured by Unmanned Aerial Vehicles (UAVs) play a significant role in many fields. However, with the development of UAV technology, challenges such as detecting small and dense objects against complex backgrounds have emerged. In this paper, we propose LGFF-YOLO, a detection model that integrates a novel local–global feature fusion method with the YOLOv8 baseline, specifically designed for small object detection in UAV imagery. Our innovative approach employs the Global Information Fusion Module (GIFM) and the Four-Leaf Clover Fusion Module (FLCM) to enhance the fusion of multi-scale features, improving detection accuracy without increasing model complexity. Next, we proposed the RFA-Block and LDyHead to control the total number of model parameters and improve the representation capability for small object detection. Experimental results on the VisDrone2019 dataset demonstrate a 38.3% mAP with only 4.15M parameters, a 4. 5% increase over baseline YOLOv8, while achieving 79.1 FPS for real-time detection. These advancements enhance the model’s generalization capability, balancing accuracy and speed, and significantly extend its applicability for detecting small objects in UAV images.