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To date, a large number of long non-coding RNAs (lncRNAs) have been recently discovered through functional genomics studies. Importantly, lncRNAs have been shown, in many cases, to function as master regulators for gene expression and thus, they can play a critical role in various biological functions and disease processes including cancer. Although the lncRNA-mediated gene expression involves various mechanisms, such as regulation of transcription, translation, protein modification, and the formation of RNA–protein or protein–protein complexes, in this review, we discuss the latest developments primarily in important cell signaling pathways regulated by lncRNAs in cancer.

In \"Probing Theoretically into Central and Eastern Europe: Transactions, Resources, and Institutions,\" we outlined the contributions of research in Central and Eastern Europe (CEE) to theoretical debates in business research. In this retrospective, we reflect upon the evolution of the field over the past decade. With the fading impact of CEE's distinct shared history, we suggest that CEE best be analyzed as emerging economies, rather than as a distinct geographic entity. Emerging economy business research is converging on common themes and shared theoretical ideas, while identifying critical variations that constrain generalizations among and beyond emerging economies. This research thus highlights the need to develop a better understanding of the boundary conditions of scholarly theories of business knowledge. Over the past decade, the institutionbased view has emerged from distinct intellectual traditions in institutional economics, organizational theory, and the analysis of business-government bargaining. Research in these converging lines of theorizing places contextual variations at the center of explanations of business phenomena around the world. We suggest that the institution-based view is evolving toward a paradigm, and offer suggestions on how to advance this research agenda further, in particular by exploring how firms engage with different sets of potentially conflicting institutions at multiple levels and locations.

The growth of outward foreign direct investment from emerging markets has led to increased scholarly attention on the internationalization of emerging market firms (EMFs). We break from the recent strategic approach on internationalizing EMFs to develop a problematization approach, which permits us to introduce a geographic relational perspective. We use this perspective to highlight process thinking, complex social realities, and relational practice as means by which to better develop theory on the internationalization of EMFs. Our emergent approach emphasizes the need to view EMF internationalization as deeply situated in multifaceted contextual influences, as influenced by path dependence and as manifested in practice. These three relational tenets (contextuality, path dependence, and practice) are central to our geographic relational approach’s ability to generate new challenging research questions for understanding EMF internationalization. Consequently, we add novelty to the international business domain by bringing space and process to the forefront of the EMF research agenda.

What signals do firms in emerging economies send to stakeholders when they adopt corporate social responsibility (CSR) practices? We argue that in emerging economies, firms that adopt CSR practices positively signal investors that their firms have superior capabilities for filling institutional voids. From an institution-based view, we hypothesize that the institutional environment moderates the signaling effect of CSR on a firm's financial performance. Based on a sample of firms from ten Asian emerging economies, we find a positive relationship between CSR practices and financial performance. This positive relationship is stronger in the less developed capital market than in the more developed one. The financial benefits of CSR practices are also more salient in the low information diffusion market than in the high one. We emphasize that signaling theory and the institution-based view can jointly contribute to the CSR literature.

Fascia iliaca block or femoral nerve block is used frequently in hip fracture patients because of their opioid-sparing effects and reduction in opioid-related adverse effects. A recent anatomical study on hip innervation led to the identification of relevant landmarks to target the hip articular branches of femoral nerve and accessory obturator nerve. Using this information, we developed a novel ultrasound-guided approach for blockade of these articular branches to the hip, the PENG (PEricapsular Nerve Group) block. In this report, we describe the technique and its application in 5 consecutive patients.

We present Keck/DEIMOS spectroscopy of the first complete sample of ultradiffuse galaxies (UDGs) in the Virgo cluster. We select all UDGs in Virgo that contain at least 10 globular cluster (GC) candidates and are more than 2.5σ outliers in scaling relations of size, surface brightness, and luminosity (a total of 10 UDGs). We use the radial velocity of their GC satellites to measure the velocity dispersion of each UDG. We find a mixed bag of galaxies, from one UDG that shows no signs of dark matter, to UDGs that follow the luminosity–dispersion relation of early-type galaxies, to the most extreme examples of heavily dark matter–dominated galaxies that break well-known scaling relations such as the luminosity–dispersion or U-shaped total mass-to-light ratio relations. This is indicative of a number of mechanisms at play forming these peculiar galaxies. Some of them may be the most extended version of dwarf galaxies, while others are so extreme that they seem to populate dark matter halos consistent with that of the Milky Way or even larger. Even though Milky Way stars and other GC interlopers contaminating our sample of GCs cannot be fully ruled out, our assessment of this potential problem and simulations indicate that the probability is low and, if present, unlikely to be enough to explain the extreme dispersions measured. Further confirmation from stellar kinematics studies in these UDGs would be desirable. The lack of such extreme objects in any of the state-of-the-art simulations opens an exciting avenue of new physics shaping these galaxies.

It is generally believed that long-duration gamma-ray bursts (GRBs) originate from the core collapse of rapidly spinning massive stars, and at least some of them are powered by hyperaccreting black holes (BHs). However, definite proofs about the progenitor and central engine of these GRBs have not been directly observed in the past. Here, we report the existence of a quasiperiodic oscillation (QPO) signature with periodic frequency ∼0.02 Hz in the early X-ray afterglow phase of GRB 220711B. Such a low-frequency QPO likely signals the precession of a relativistic jet launched from a GRB hyperaccreting BH central engine. The energy injection signature from the late X-ray observations (from 5 × 102 s ∼ 1 × 104 s) is consistent with the precession hypothesis. The prompt gamma-ray light curve does not show any QPO signature, suggesting that the X-ray flaring emission in the early afterglow phase and prompt emission likely originate from different accretion processess, indicating that the progenitor stars of GRBs have a core-envelope structure with a stratified angular momentum distribution and the late-time accretion disk likely has a misalignment with respect to the rotation axis of the BH. Such a misalignment is not expected in a canonical collapsar model. As a result, the QPO signature in GRB 220711B may reveal a new formation channel of long GRBs, possibly a stellar-merger-induced core collapse, with the orbital angular momentum of the binary misaligned with the spin axis of the collapsing star.

We investigate the impact of market-supporting institutions on business strategies by analyzing the entry strategies of foreign investors entering emerging economies. We apply and advance the institution-based view of strategy by integrating it with resource-based considerations. In particular, we show how resource-seeking strategies are pursued using different entry modes in different institutional contexts. Alternative modes of entry--greenfield, acquisition, and joint venture (JV)--allow firms to overcome different kinds of market inefficiencies related to both characteristics of the resources and to the institutional context. In a weaker institutional framework, JVs are used to access many resources, but in a stronger institutional framework, JVs become less important while acquisitions can play a more important role in accessing resources that are intangible and organizationally embedded. Combining survey and archival data from four emerging economies, India, Vietnam, South Africa, and Egypt, we provide empirical support for our hypotheses.

Do outside directors on corporate boards make a difference in firm performance during institutional transitions? What leads to the practice of appointing outside directors in the absence of legal mandate? This article addresses these two important questions by drawing not only on agency theory, but also resource dependence and institutional theories. Taking advantage of China's institutional transitions, our findings, based on an archival database covering 405 publicly listed firms and 1211 company--years, suggest that outsider directors do make a difference in firm performance, if such performance is measured by sales growth, and that they have little impact on financial performance such as return on equity (ROE). The results also document a bandwagon effect behind the diffusion of the practice of appointing outsiders to corporate boards. The article not only highlights the need to incorporate multiple theories beyond agency theory in corporate governance research, but also generates policy implications in light of the recent trend toward having more outside directors on corporate boards in emerging economies.

Pain inhibition by additional somatosensory input is the rationale for the widespread use of Transcutaneous Electrical Nerve Stimulation (TENS) to relieve pain. Two main types of TENS produce analgesia in animal models: high-frequency (∼50–100 Hz) and low-intensity ‘conventional’ TENS, and low-frequency (∼2–4 Hz) and high-intensity ‘acupuncture-like’ TENS. However, TENS efficacy in human participants is debated, raising the question of whether the analgesic mechanisms identified in animal models are valid in humans. Here, we used a sham-controlled experimental design to clarify the efficacy and the neurobiological effects of ‘conventional’ and ‘acupuncture-like’ TENS in 80 human volunteers. To test the analgesic effect of TENS we recorded the perceptual and brain responses elicited by radiant heat laser pulses that activate selectively Aδ and C cutaneous nociceptors. To test whether TENS has a long-lasting effect on brain state we recorded spontaneous electrocortical oscillations. The analgesic effect of ‘conventional’ TENS was maximal when nociceptive stimuli were delivered homotopically, to the same hand that received the TENS. In contrast, ‘acupuncture-like’ TENS produced a spatially-diffuse analgesic effect, coupled with long-lasting changes both in the state of the primary sensorimotor cortex (S1/M1) and in the functional connectivity between S1/M1 and the medial prefrontal cortex, a core region in the descending pain inhibitory system. These results demonstrate that ‘conventional’ and ‘acupuncture-like’ TENS have different analgesic effects, which are mediated by different neurobiological mechanisms. •‘Acupuncture-like’ TENS produces a spatially-diffuse analgesic effect.•‘Conventional’ TENS produces a spatially-localized analgesic effect.•‘Acupuncture-like’ TENS results in an enhancement of ongoing α oscillation in S1/M1.•‘Acupuncture-like’ TENS results in an enhanced connectivity between S1/M1 and mPFC.•These two types of TENS are mediated by different neurobiological mechanisms.