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Einstein–Gauss–Bonnet theory is a string-generated gravity theory when approaching the low energy limit. By introducing the higher order curvature terms, this theory is supposed to help to solve the black hole singularity problem. In this work, we investigate the evaporation of the static spherically symmetric neutral AdS black holes in Einstein–Gauss–Bonnet gravity in various spacetime dimensions with both positive and negative coupling constant α. By summarizing the asymptotic behavior of the evaporation process, we find the lifetime of the black holes is dimensional dependent. For α>0, in D⩾6 cases, the black holes will be completely evaporated in a finite time, which resembles the Schwarzschild-AdS case in Einstein gravity. While in D=4,5 cases, the black hole lifetime is always infinite, which means the black hole becomes a remnant in the late time. Remarkably, the cases of α>0,D=4,5 will solve the terminal temperature divergent problem of the Schwarzschild-AdS case. For α<0, in all dimensions, the black hole will always spend a finite time to a minimal mass corresponding to the smallest horizon radius rmin=2|α| which coincide with an additional singularity. This implies that there may exist constraint conditions to the choice of coupling constant.

Total and differential white blood cell counts are important for the diagnostic evaluation of suspected diseases. To facilitate the interpretation of total and differential white blood cell counts in pediatric patients, the present study investigated age-dependent changes in total and differential white blood cell counts in healthy reference children. Data were obtained from the Pediatric Reference Intervals in China study (PRINCE), which aims to establish and verify pediatric reference intervals for Chinese children based on a nationwide multicenter cross-sectional study from January 2017 to December 2018. Quantile curves were calculated using the generalized additive models for location, shape, and scale method. The 2.5th, 50th, and 97.5th quantile curves were calculated for both total and differential white blood counts. Percents of stacked area charts were used to demonstrate the proportions of differential white blood cells. All statistical analyses were performed using R software. Both 50th and 97.5th quantiles of total white blood cell count and monocyte count were highest at birth, then rapidly decreased in the first 6 months of life; relatively slow reduction continued until 2 years of age. The lymphocyte count was low during infancy and increased to its highest level at 6 months of age; it then exhibited moderate and continuous reduction until approximately 9 years of age. The pattern of neutrophil count changed with age in a manner opposite to that of lymphocyte count. Besides, there were two inter-sections of lymphocyte count and neutrophil count during infancy and at approximately 5 years of age, based on locally weighted regression (LOESS) analysis. There were no apparent age-related changes in eosinophil or basophil counts. These data regarding age-related changes in total and differential white blood cell counts can be used to assess the health of pediatric patients and guide clinical decisions.

In this paper, we investigate the shadows and rings of the charged Horndeski black hole illuminated by accretion flow that is both geometrically and optically thin. We consider two types of accretion models: spherical and thin-disk accretion flow. We find that in both types of models, the size of the charged Horndeski black hole shadow decreases with the increase of the charge, and it decreases more slowly for the Reissner–Nordström (RN) black hole. In the spherical accretion flow model, we find that the increase of the charge of Horndeski black hole brightens the light ring around it, and it brightens more significantly in comparison with RN black hole. Due to the Doppler effect, the charged Horndeski black holes with accretion flow of radial motion have darker shadows than those with the static accretion flow, but the size of the shadow is not affected by accretion flow motion. In the thin disk-shaped accretion flow model, we find that the brightness of the light ring around the charged Horndeski black hole is dominated by the direct emission from the accretion flow, and the contribution from lensed rings is relatively small, and that from the photon rings is negligible. We also find that the ring brightness decreases as the charge of Horndeski black hole increases, and the decrease is more significant than that in the RN black hole case. Moreover, the radiation position of the accretion flow can affect the shadow size and the ring brightness of the charged Horndeski black hole.

Abstract The extensive use of chemical pesticides, such as herbicides, has resulted in significant environmental pollution. Microbial degradation represents a crucial approach for managing this pesticide-associated pollution, with enrichment culturing serving as a method for isolating pesticide-degrading microorganisms. However, the efficiency of this strategy is limited, often yielding only a few isolated strains. In this study, a new mineral salt medium (MSM) was developed, and a high-throughput method was used for screening pendimethalin-degrading bacteria by measuring the bacterial growth in the MSM. The utilization of this method resulted in the isolation of 56 pendimethalin-degrading bacteria from approximately 2000 bacterial strains, including 37 Bacillus spp., 10 Alcaligenes spp., 5 Pseudomonas spp., and other 4 strains identified for the first time as pendimethalin-degrading strains. This method may hold promise not only for isolating bacterial strains capable of degrading other pesticides but also for facilitating the utilization of the substantial bacterial strains stored in bacterial banks. A high-throughput method for screening pendimethalin-degrading bacteria was developed and resulted in the isolation of 56 pendimethalin-degrading bacteria from approximately 2000 bacterial strains.

This study elucidates the mechanism by which GLIS Family Zinc Finger 2 (GLIS2) promotes epithelial‐mesenchymal transition (EMT) in gastric cancer through biglycan (BGN) activation and Wnt/β‐catenin stimulation. By analyzing 18 pairs of GC tissues and establishing in vitro models (combining GLIS2 knockdown/BGN overexpression with Wnt pathway modulators), we demonstrated that GLIS2 directly binds to the BGN promoter to enhance its transcription, thereby activating Wnt/β‐catenin signaling and significantly promoting GC cell migration, invasion, and EMT. Functional rescue experiments confirmed that BGN overexpression reverses the inhibitory effects of GLIS2 knockdown, while the Wnt/β‐catenin inhibitor XAV‐939 effectively blocks BGN's tumor‐promoting effects. These findings establish the crucial role of the GLIS2‐BGN‐Wnt/β‐catenin axis in regulating GC EMT and identify novel potential therapeutic targets for GC treatment.

We define thermodynamic pressure P by work density W as the conjugate quantity of thermodynamic volume V from field equation. We derive the equations of state P=P(V, T) for the Friedmann–Robertson–Walker (FRW) universe in Einstein gravity and a modified gravity respectively. We find that the equation of state from Einstein gravity shows no P-V phase transition, while the equation of state from the modified gravity does, where the critical exponents are the same as those in mean field theory.

In this paper, the holographic p-wave superfluid model with charged complex vector field is studied in dRGT massive gravity beyond the probe limit. The stability of p-wave and p + ip solutions are compared in the grand canonical ensemble. The p-wave solution always get lower value of grand potential than the p + ip solution, showing that the holographic system still favors an anisotropic (p-wave) solution even with considering a massive gravity theory in bulk. In the holographic superconductor models with dRGT massive gravity in bulk, a key scaling symmetry is found to be violated by fixing the reference metric parameter c 0 . Therefore, in order to get the dependence of condensate and grand potential on temperature, different values of horizon radius should be considered in numerical work. With a special choice of model parameters, we further study the dependence of critical back-reaction strength on the graviton mass parameter, beyond which the superfluid phase transition become first order. We also give the dependence of critical temperature on the back reaction strength b and graviton mass parameter m 2 .

Human eukaryotic prohibitin (prohibitin-1 and prohibitin-2) is a membrane protein with different cellular localizations. It is involved in multiple cellular functions, including energy metabolism, proliferation, apoptosis, and senescence. The subcellular localization of prohibitin may determine its functions. Membrane prohibitin regulate the cellular signaling of membrane transport, nuclear prohibitin control transcription activation and the cell cycle, and mitochondrial prohibitin complex stabilize the mitochondrial genome and modulate mitochondrial dynamics, mitochondrial morphology, mitochondrial biogenesis, and the mitochondrial intrinsic apoptotic pathway. Moreover, prohibitin can translocates into the nucleus or the mitochondria under apoptotic signals and the subcellular shuttling of prohibitin is necessary for apoptosis process. Apoptosis is the process of programmed cell death that is important for the maintenance of normal physiological functions. Consequently, any alteration in the content, post-transcriptional modification (i.e. phosphorylation) or the nuclear or mitochondrial translocation of prohibitin may influence cell fate. Understanding the mechanisms of the expression and regulation of prohibitin may be useful for future research. This review provides an overview of the multifaceted and essential roles played by prohibitin in the regulation of cell survival and apoptosis.

We present a novel interpretation of the thermodynamics of perfect fluid dark matter (PFDM) black hole based on Misner–Sharp energy and then investigate its evaporation behavior. We find that the ratio between dark sector initial density and black hole horizon radius significantly influences black hole evaporation behaviors. We demonstrate that the presence of the dark sector can significantly extend the lifetime of a black hole which is similar to the Reissner–Nordström case. Our work reformulates the thermodynamics of PFDM black holes and points out the existence of long-lived black holes in the presence of the dark sector.

We investigate the gravitational lensing effect around a spherically symmetric black hole, whose metric is obtained from the Einstein field equation with electric charge and perfect-fluid dark matter contributing to its energy-momentum tensor. We do the calculation analytically in the weak field limit and we assume that both the charge and the dark matter are much less abundant (only give rise to the next-leading-order contribution) in comparison to the black hole mass. In particular, we derive the light deflection angle and the size of the Einstein ring, where approximations up to the next-leading order are done with extra care, especially for the logarithmic term from perfect-fluid dark matter. We expect our results will be useful in the future to relate the theoretical model of perfect fluid dark matter with observations of celestial bodies immersed in thin dark matter.