Explore the vast range of titles available.

Van der Waals （vdW） heterojunctions are equipped to avert dangling bonds due to weak, inter-layer vdW force, and ensure strong in-plane covalent bonding for two-dimensional layered structures. We fabricated four heterojunctions devices of different layers based on p-type distorted 1T-MX2 ReSe2 and n-type hexagonal MoS2 nanoflakes, and measured their electronic and optoelectronic properties. The device showed a high rectification coefficient of 500 for the diode, a high ON/OFF ratio and higher electron mobility for the field-effect transistor （FET） compared with the individual components, and a high current responsivity （Rλ） and external quantum efficiency （EQE） of 6.75 A/W and 1,266%, respectively, for the photodetector.

Abstract Background: Huaier granule is an important medicinal fungus extract widely used in cancer treatment. Previous retrospective studies have reported its effectiveness in breast cancer patients, but the imbalanced baseline characteristics of participants could have biased the results. Therefore, this retrospective study aimed to examine the efficacy of Huaier granule on the prognosis of breast cancer patients. Methods: In this single-center cohort study, breast cancer patients diagnosed and treated at the Guangdong Provincial Hospital of Chinese Medicine between 2009 and 2017 were selected. The data were retrospectively analyzed and divided into two groups according to whether the patients received Huaier granules. The propensity score matching (PSM) method was used to eliminate selection bias. The disease-free survival (DFS) and overall survival (OS) for these groups were compared using the Kaplan–Meier method and the Cox regression. Results: This study included 214 early invasive breast cancer patients, 107 in the Huaier group and 107 in the control group. In the Kaplan–Meier analysis, the 2-year and 5-year DFS rates were significantly different in the Huaier group and control group (hazard ratio [HR], 0.495; 95% confidence interval [CI], 0.257–0.953; P = 0.023). The 2-year and 5-year OS rates were also significantly different (HR, 0.308; 95% CI, 0.148–0.644; P = 0.001). On multivariable Cox regression, Huaier granule was associated with improved DFS (HR, 0.440; 95% CI, 0.223–0.868; P = 0.018) and OS (HR, 0.236; 95% CI, 0.103–0.540; P = 0.001). Conclusion: In this retrospective study, Huaier granules improved the DFS and OS of early invasive breast cancer patients, providing real-world evidence for further prospective studies on treating breast cancer with Huaier granules.

National parks serve as critical spatial units for conserving ecological baselines, maintaining genetic diversity, and delivering essential ecosystem services. However, accelerating socio-economic development has increasingly intensified the conflict between ecological protection and transportation infrastructure. Ecologically sustainable transportation planning is, therefore, essential to mitigate habitat fragmentation, facilitate species migration, and conserve biodiversity. This study examines the Giant Panda National Park and its buffer zone, focusing on six mammal species: giant panda, Sichuan snub-nosed monkey, leopard cat, forest musk deer, rock squirrel, and Sichuan takin. By integrating Maxent ecological niche modeling with circuit theory, it identified ecological source areas and potential corridors, and employed a two-step screening approach to design species-specific wildlife crossings. In total, 39 vegetated overpasses were proposed to serve all target species; 34 underpasses were integrated using existing bridge and culvert structures to minimize construction costs; and 27 canopy bridges, incorporating suspension cables and elevated pathways, were designed to connect forest canopies for arboreal species. This study established a multi-species and multi-scale conservation framework, providing both theoretical insights and practical strategies for ecologically integrated transportation planning in national parks, contributing to the synergy between biodiversity conservation and sustainable development goals.

Background In clinical practice, psoriasis is a prevalent chronic inflammatory cutaneous disease featured with the development of red plaque with silvery scales, which considerably affects cutaneous health and quality of life of those afflicted. Objective This research aimed to examine the association between the body roundness index (BRI) and psoriasis, using data sourced from the National Health and Nutrition Examination Survey (NHANES). Methods Our study used a cross-sectional design, including 8,479 adults, of whom 234 were diagnosed with psoriasis. Multivariable logistic regression was used to analyze the relationship between BRI and psoriasis, with stepwise adjustments for covariables. Results Results from multivariable logistic regression analyses indicated a significant positive relationship between BRI and the risk of developing psoriasis; specifically, after comprehensive adjustment for covariables, per 1 unit increase in BRI was linked to an 11% rise in psoriasis risk (OR = 1.11, 95% CI = 1.05–1.17). Furthermore, psoriasis patients exhibited higher average BRI compared to non-psoriasis patients and a greater prevalence of comorbidities such as hypertension and smoking. Conclusion These findings suggest that higher BRI is positively correlated with the risk of psoriasis in the adult population in the US. BRI could potentially act as a practical anthropometric index for more accurately predicting the risk of developing psoriasis.

Background The ocular manifestations of cat scratch disease (CSD) are diverse. We report a rare case of isolated choroidal granuloma with serous retinal detachment (SRD) secondary to Bartonella henselae infection in a patient without feline exposure. Case presentation A retrospective analysis of a 38-year-old female presenting in March 2024 with unilateral visual impairment and metamorphopsia. Diagnostic evaluations included multimodal imaging (spectral-domain optical coherence tomography [SD-OCT], fluorescein angiography [FA], indocyanine green angiography [ICGA]), and serologic testing. Ocular examination revealed a yellowish-white subretinal lesion with associated SRD superotemporal to the optic disc. SD-OCT demonstrated a dome-shaped choroidal elevation with homogeneous hyporeflectivity and subretinal fluid. FA showed late hyperfluorescence of the lesion, while ICGA revealed persistent hypofluorescence. Serologic testing confirmed elevated Bartonella henselae IgG titers (1:256). The patient had no systemic symptoms or history of feline contact and initially received systemic steroids, topical anti-inflammatory/antibiotic agents, and traditional Chinese medicine. All treatments were discontinued after 24 h, and the lesion subsequently resolved with complete resolution of subretinal fluid and best-corrected visual acuity (BCVA) recovery to 20/20. Conclusion Ocular bartonellosis may manifest as an isolated choroidal granuloma with vision-threatening SRD, even in the absence of feline exposure. Multimodal imaging and serologic testing are critical for diagnosis. The condition may resolve spontaneously without targeted antimicrobial therapy for Bartonella infection, even in the absence of anti-inflammatory therapy.

Objective We aimed to probe the diagnostic value of transvaginal color Doppler ultrasound (TV-CDU) parameters in cesarean scar pregnancy (CSP) and CSP sub-types, and the relevant factors affecting patients’ surgical effects. Methods Seventy-five CSP patients (all requested termination of pregnancy) were selected as the observation group, and 75 normal pregnant women with a history of cesarean section were selected as the control group. All the study subjects underwent TV-CDU and their cesarean scar muscle (CSM) thickness, minimum sagittal muscle thickness and resistance index (RI) of blood flow in the anterior wall of the lower uterine segment were calculated. The diagnostic value of CSM, minimum sagittal muscle thickness, and RI for CSP and CSP sub-types was analyzed. The patients in the observation group were grouped into the effective group and the ineffective group according to whether the surgical treatment was effective or not, and the independent factors affecting CSP efficacy were analyzed. Results The observation group had lower CSM, minimum sagittal muscle thickness and RI than the control group. CSM, RI, and minimum sagittal thickness in patients with type II CSP were lower than those in patients with type I, and these indicators in patients with type III were lower than those in patients with type II. The area under the curve (AUC) of CSM, RI and minimum sagittal muscle thickness in combination for CSP diagnosis and the AUC for CSP sub-types were higher than those of each indicator alone. Gestational sac size and CSM were independent factors affecting CSP treatment. Conclusion Changes in TV-CDU parameters facilitates CSP diagnosis after cesarean section. CSM, minimum sagittal muscle thickness changes, and RI in combination possesses high value for CSP diagnosis and CSP sub-types. Gestational sac size and CSM are independent factors affecting CSP treatment.

PurposeTo compare the sensitivity and specificity of identifying and evaluating the choroidal neovascularisation (CNV) in punctate inner choroidopathy (PIC) by optical coherence tomography angiography (OCTA) versus dye angiography.MethodsConsecutive patients diagnosed with PIC were enrolled in this study from June 2016 to December 2019. During the same visit, each patient underwent comprehensive ophthalmological and multimodal imaging examinations. The diagnostic accuracy of different modalities was evaluated.ResultsThe study included 160 affected eyes from 123 patients. Ninety-five eyes (59.38%) were identified with secondary CNV by multimodal imaging. The sensitivity and specificity for CNV detection with OCTA alone were 89.47% and 98.46%, respectively. OCTA also provided the morphology of CNV to determine the activity of CNV with a sensitivity of 86.67% and a specificity of 94.29%.ConclusionsIn this study, we investigated the utility of OCTA in the diagnosis and evaluation of patients with CNV secondary to PIC. Compared with dye angiography, OCTA show convincing diagnosis accuracy. Although OCTA has several limitations and is not sufficient to replace dye angiography in clinical practice, it can provide clinicians with a non-invasive way to monitor patients with CNV secondary to PIC and guide treatment decisions.

Jurassic lacustrine shale in the Sichuan Basin is a focal exploration area in China, while the pronounced heterogeneity presents challenges, necessitating detailed research as a prerequisite. This study aims at the Jurassic Ziliujing Formation Da’anzhai shale in the central Sichuan Basin, systematically characterizing its geological features. Employing geochemical methods, we reconstructed the paleo-sedimentary environments and explored the mechanisms behind the organic matter enrichment. The findings reveal that the Da’anzhai shale exhibits three lithofacies: organic-rich argillaceous shale (ORA), organic-poor argillaceous shale (OPA), and organic-rich mixed shale (ORM). The sedimentary period was marked by a warm and humid climate, predominantly depositing in anoxic environments with freshwater to brackish conditions. The watershed areas that are provenance sources for the shale clastics are experiencing strong weathering. Significant differences in the sedimentary environments of various lithofacies’ shale were observed. Redox conditions and paleoclimate were identified as the primary factors controlling organic matter enrichment in the Da’anzhai shale of the study area. Salinity also played a role in organic matter enrichment, while terrigenous debris influx and paleo-productivity did not exert a significant controlling effect on organic matter enrichment. Utilizing the reconstructed ancient sedimentary environments, we developed sedimentary models for different lithofacies’ shale, contributing to a deeper understanding of lithofacies’ diversity and the mechanisms governing organic matter enrichment in lacustrine environments. This study provides new information for further understanding the response mechanism of lacustrine shales to the Toarcian Oceanic Anoxic Event in the Early Jurassic from the perspective of elemental geochemistry.

This study investigates the early oncogenic transformation of gastric epithelial cells (GES-1) and adenocarcinoma cells (AGS) following long-term exposure to N-nitroso compounds (NOCs), using N-methyl-N’-nitro-N-nitrosoguanidine (MNNG) as a model carcinogen. Prolonged MNNG treatment enhanced proliferation, migration, invasion, and anchorage-independent growth. These effects were accompanied by persistent activation of endoplasmic reticulum stress (ERS) and autophagy, characterized by elevated PERK, eIF2α, ATF4, CHOP, Beclin-1, and LC3-II, and reduced p62. Long non-coding RNA nuclear-enriched abundant transcript 1 (NEAT1) was markedly upregulated and acted as a competing endogenous RNA, sponging microRNA-329-3p (miR-329-3p) to derepress ATF4. Silencing NEAT1 or restoring miR-329-3p expression suppressed ERS, autophagy, and malignant traits. These findings establish a NEAT1/miR-329-3p/ATF4 signaling axis that links stress response to early gastric epithelial transformation, offering a potential target for intervention.

Low-light image enhancement (LLIE) remains a challenging task due to the scarcity of paired training data and the complex signal-dependent noise inherent in low-light scenes. To address these issues, this paper proposes a fully unsupervised framework named Wavelet-Guided Zero-Reference Diffusion (WZD) for natural low-light image restoration. WZD leverages an ImageNet-pre-trained diffusion prior and a multi-scale representation of the Discrete Wavelet Transform (DWT) to restore natural illumination from a single dark image. Specifically, the input low-light image is first processed by a Practical Exposure Corrector (PEC) to provide an initial robust luminance baseline. It is then converted from the RGB to the YCbCr color space. The Y channels of the input image and the current diffusion estimate are decomposed into four orthogonal sub-bands—LL, LH, HL, and HH—and fused via learnable, step-wise weights while preserving structural integrity. An exposure control loss and a detail consistency loss are jointly employed to suppress over/under-exposure and preserve high-frequency details. Unlike recent approaches that rely on complex supervised training or lack physical guidance, our method integrates wavelet guidance with a zero-reference learning framework, incorporates the PEC module as a physical prior, and achieves significant improvements in detail preservation and noise suppression without requiring paired training data. Comprehensive experiments on the LOL-v1, LOL-v2, and LSRW datasets demonstrate that WZD achieves a superior or competitive performance, surpassing all referenced unsupervised methods. Ablation studies confirm the critical roles of the PEC prior, YCbCr conversion, wavelet-guided fusion, and the joint loss function. WZD also enhances the performance of downstream tasks, verifying its practical value.