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"Perkins, Stephanie"
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Anna and the French kiss
When Anna's romance-novelist father sends her to an elite American boarding school in Paris for her senior year of high school, she reluctantly goes, and meets an amazing boy who becomes her best friend, in spite of the fact that they both want something more.
Book
Outcome for Children with Metastatic Solid Tumors over the Last Four Decades
Outcomes for pediatric solid tumors have significantly improved over the last 30 years. However, much of this improvement is due to improved outcome for patients with localized disease. Here we evaluate overall survival (OS) for pediatric patients with metastatic disease over the last 40 years.
The United States Surveillance, Epidemiology, and End Results (SEER) database was used to conduct this study. Patients diagnosed between 0 and 18 years of age with metastatic Ewings sarcoma, neuroblastoma, osteosarcoma, rhabdomyosarcoma or Wilms tumor were included in the analysis.
3,009 patients diagnosed between 1973-2010 met inclusion criteria for analysis. OS at 10 years for patients diagnosed between 1973-1979, 1980-1989, 1990-1999 and 2000-2010 was 28.3%, 37.2%, 44.7% and 49.3%, respectively (p<0.001). For patients diagnosed between 2000-2010, 10-year OS for patients with Ewing sarcoma, neuroblastoma, osteosarcoma, rhabdomyosarcoma and Wilms tumor was 30.6%, 54.4%, 29.3%, 27.5%, and 76.6%, respectively, as compared to 13.8%, 25.1%, 13.6%, 17.9% and 57.1%, respectively, for patients diagnosed between 1973-1979. OS for neuroblastoma significantly increased with each decade. For patients with osteosarcoma and Ewing sarcoma, there was no improvement in OS over the last two decades. There was no improvement in outcome for patients with rhabdomyosarcoma or Wilms tumor over the last 30 years.
OS for pediatric patients with metastatic solid tumors has significantly improved since the 1970s. However, outcome has changed little for some malignancies in the last 20-30 years. These data underscore the importance of continued collaboration and studies to improve outcome for these patients.
Journal Article
Lola and the boy next door
Budding costume designer Lola lives an extraordinary life in San Francisco with her two dads and beloved dog, dating a punk rocker, but when the Bell twins return to the house next door Lola recalls both the friendship-ending fight with Calliope, a figure skater, and the childhood crush she had on Cricket.
BOOK
Patterns of care and outcomes of patients with pleomorphic xanthoastrocytoma: a SEER analysis
To study the clinical characteristics, treatment approach and outcome of pleomorphic xanthoastrocytoma (PXA), patients were identified using the National Cancer Intitute's Surveillance, Epidemiology, and End Results (SEER) database. A total of 214 patients were identified with PXA using the November 2010 submission. Patient demographics, tumor characteristics, extent of surgical resection, the use of radiotherapy, and overall survival were evaluated. Overall survival for PXA was then compared to that of pilocytic astrocytoma, oligodendroglioma, ependymom and glioblastoma also using the SEER database. Kaplan–Meier, univariate and multivariate analyses were performed. The majority of patients were found to be young adults with the most common tumor location being temporal lobe. Surgery was performed on most (95 %) patients, while 25 % of patients received radiation therapy. Five and 10 year overall survival rates were 75 and 67 %, respectively. Grade was only available for a limited number of patients but appeared to affect prognosis. Patients with grade IV tumors had a median overall survival of 45 months, whereas median survival was not reached for grade I–III patients. On multivariate analysis, male gender and increasing age were associated with worse overall survival (
p
values 0.05 and <0.006, respectively). Extent of resection trended towards significance in favor of gross total resection. PXA is a rare diagnosis that affects young adults. Surgical resection is the primary modality of treatment with an overall good prognosis. Elderly patients, those with higher grade disease and patients with incomplete resections may have a worse prognosis. The role of radiation therapy for PXA remains unclear but is more often used for patients with high grade tumors. Compared to other common brain tumors, PXA’s appear to fare worse than pilocytic astrocytoma and oligodendroglioma, especially in younger patients. However, even high grade PXA patients have significantly better overall survival compared to glioblastoma.
Journal Article
There's someone inside your house : a novel
\"Hawaii-born Makani Young's new life in Nebraska is thrown into chaos when a serial killer begins to target her fellow high school students\"-- Provided by publisher.
Book
Pediatric Experience and Outcomes from the First Single-Vault Compact Proton Therapy Center
The first single-vault compact proton therapy center opened in 2013, utilizing a gantry-mounted synchrocylotron. The center was placed within a large academic radiation oncology department with a high priority for pediatric cancer care. Here we performed a retrospective study of pediatric (≤21 years) patients treated with proton therapy at our institution between 2013–2022. Patient, tumor, and treatment characteristics were obtained including race, socioeconomic status, insurance type, distance travelled, need for anesthesia, and outside referrals for proton therapy. In total, 250 pediatric patients were treated with proton therapy comprising 18% of our proton patient volume. Median follow-up was 3.1 years, 38.4% were female and 83% were white. The majority of cases were CNS (69.6%) and a large number of patients (80/250, 32%) required craniospinal irradiation. Anesthesia was required for 39.6% of patients. Average distance travelled for treatment was 111 miles and 23% of patients were referred from outside institutions for proton therapy. Insurance type was private/commercial for 61.2% followed by Medicaid for 32%. We found that 23% of patients lived in census tracts with >25% of people living below the national poverty line. Overall survival at 3 years was excellent at 83.7% with better outcomes for CNS patients compared to non-CNS patients. There were no cases of secondary malignancy at this early time point. As the world’s first compact proton therapy center, we found that proton therapy increased our pediatric volume and provided proton therapy to a diverse group of children in our region. These data highlight some of the expected patient and tumor characteristics and necessary resources for providing pediatric proton beam therapy.
Journal Article
Anna and the French kiss
When Anna's father sends her to an American boarding school in Paris for her senior year of high school, she reluctantly goes, and meets a boy who becomes her best friend, in spite of the fact that they both want something more.
Book
Critical Sets and Unavoidable Sets of Strictly Concentric Magic Squares of Odd Order and Their Application to Prime Strictly Concentric Magic Squares of Order 5
There has been much interest in the mathematical investigation of critical sets and unavoidable sets in Latin Squares, Sudoku, and their applications to practical problems in areas such as agriculture and cryptology. This paper considers the associated structures of Strictly Concentric Magic Squares (SCMSs) and Prime Strictly Concentric Magic Squares (PSCMSs). A framework of formal definitions is given that leads to the definitions of critical sets and unavoidable sets. Minimal critical sets are of interest in Latin Squares, and in this article, the cardinality of minimal critical sets of SCMS is given for all n, n odd. Two families of unavoidable sets are established for SCMS, leading to a complete classification of unavoidable sets of minimum PSCMS of order 5.
Journal Article
Prime Strictly Concentric Magic Squares of Odd Order
Magic squares have been widely studied, with publications of mathematical interest dating back over 100 years. Most studies construct and analyse specific subsets of magic squares, with some exploring links to puzzles, number theory, and graph theory. The subset of magic squares this paper focuses on are those termed prime strictly concentric magic squares (PSCMS), and their general definitions, examples, and important properties are also presented. Previously, only the minimum centre cell values of PSCMS of odd order 5 to 19 were presented, by Makarova in 2015. In this paper, the corresponding list of primes for all minimum PSCMS of order 5 is given, and the number of minimum PSCMS of order 5 is enumerated.
Journal Article
Novel roles for A‐type lamins in telomere biology and the DNA damage response pathway
A‐type lamins are intermediate filament proteins that provide a scaffold for protein complexes regulating nuclear structure and function. Mutations in the
LMNA
gene are linked to a variety of degenerative disorders termed laminopathies, whereas changes in the expression of lamins are associated with tumourigenesis. The molecular pathways affected by alterations of A‐type lamins and how they contribute to disease are poorly understood. Here, we show that A‐type lamins have a key role in the maintenance of telomere structure, length and function, and in the stabilization of 53BP1, a component of the DNA damage response (DDR) pathway. Loss of A‐type lamins alters the nuclear distribution of telomeres and results in telomere shortening, defects in telomeric heterochromatin, and increased genomic instability. In addition, A‐type lamins are necessary for the processing of dysfunctional telomeres by non‐homologous end joining, putatively through stabilization of 53BP1. This study shows new functions for A‐type lamins in the maintenance of genomic integrity, and suggests that alterations of telomere biology and defects in DDR contribute to the pathogenesis of lamin‐related diseases.
Journal Article