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The attributions made to faces are well described by two dimensions of apparent trustworthiness (valence or warmth) and apparent competence (dominance and power) (Todorov A, Mende-Siedlecki P, Dotsch R. Curr Opin Neurobiol, 2013, 23, 373–80). This model has been extended to include a third dimension of apparent age and attractiveness (Sutherland CAM, Oldmeadow JA, Santos IM, Towler J, Michael Burt D, Young AW. Cognition, 2013, 127, 105–18). Previous research has tested the association between appearance and leadership attainment for high-level leaders such as elite politicians and chief executive officers of top performing organisations in the US and Western Europe. Here we focus on a Chinese organisational context and explore how facial attributions are associated with appointment at mid-level managerial positions. Participants rated leadership, competence, trustworthiness, attractiveness and age of faces of male employees of a Chinese Real Estate company. Our findings reveal that apparent trustworthiness and age are more critical predictors of leadership attainment than competence or attractiveness in the context of mid-level management in China. The study supports the three-dimensional attribution framework and reaffirms the importance of facial cues in leadership selection across diverse cultural settings.

Fashion stylists advise clothing colours according to personal categories that depend on skin, hair and eye colour. These categories are not defined scientifically, and advised colours are inconsistent. Such caveats may explain the lack of formal tests of clothing colour aesthetics. We assessed whether observers preferred clothing colours that are linked to variation in melanin levels among White women. For this, we presented 12 women's faces: six with fair skin (relatively lower in melanin) and six with tanned skin (relatively higher in melanin). Across two experiments, observers (N = 96 and 75) selected the colour (hue and saturation or hue and value) of simulated clothing that most suited the skin tone of each face. Observers showed strong preferences for red and blue hues, and in addition favoured ‘cool’ blue hues to match fair skin and ‘warm’ orange/red hues to match tanned skin. This finding suggests that skin tone can determine colour preferences for clothes.

Pancreatic ductal adenocarcinoma (PDAC) is almost uniformly fatal; however, some improvement in overall survival has been achieved with the introduction of nanocarriers that deliver irinotecan or paclitaxel. Although it is generally assumed that nanocarriers rely principally on abnormal leaky vasculature for tumor access, a transcytosis transport pathway that is regulated by neuropilin-1 (NRP-1) has recently been reported. NRP-1-mediated transport can be triggered by the cyclic tumor-penetrating peptide iRGD. In a KRAS-induced orthotopic PDAC model, coadministration of iRGD enhanced the uptake of an irinotecan-loaded silicasome carrier that comprises lipid bilayer-coated mesoporous silica nanoparticles (MSNPs); this uptake resulted in enhanced survival and markedly reduced metastasis. Further, ultrastructural imaging of the treated tumors revealed that iRGD coadministration induced a vesicular transport pathway that carried Au-labeled silicacomes from the blood vessel lumen to a perinuclear site within cancer cells. iRGD-mediated enhancement of silicasome uptake was also observed in patient-derived xenografts, commensurate with the level of NRP-1 expression on tumor blood vessels. These results demonstrate that iRGD enhances the efficacy of irinotecan-loaded silicasome-based therapy and may be a suitable adjuvant in nanoparticle-based treatments for PDAC.

Inadequate fruit and vegetable consumption causes a considerable disease burden and premature mortality. Despite public health promotion of a healthy diet, the average consumption is still below recommended levels. Fruit and vegetable consumption influences human skin color, increasing red/yellow/orange pigment in the skin. Given that this color is deemed attractive and healthy-looking, the appearance benefit may motivate to eat more fruit and vegetables. Such appearance motivation could be particularly useful in young individuals who currently eat the least fruit and vegetables. Our objectives were to assess how widely the impact of diet on skin color is known within the UK and to compare the strength of motivation to eat fruit and vegetables based on health and appearance benefits among different demographic groups. Four groups of UK residents (N=200 per group) were recruited through the Prolific online platform. Groups comprised younger (aged 18-24) and older adults (aged 40-60) of low and high self-reported socioeconomic status (1-5 and 6-10 on a 10-point rating scale). Facial images simulating the skin color associated with low and high fruit and vegetable diets were shown to participants. Questionnaires were used to assess (1) background knowledge of the health and skin color effects of dietary fruit and vegetables, (2) the specific motivational impact of the skin color illustration, and (3) the relative importance of motivation to consume fruit and vegetables arising from health and skin color appearance benefits. We found that 61% (n=487) of all participants were unaware of the dietary-skin color association. We also found that 57% (n=457) of participants found the simple demonstration of the dietary impact on skin color positively motivating to eat more fruit and vegetables. The visual demonstration was equally motivating for participants of high and low self-reported socioeconomic status (P=.63) and different ethnic backgrounds (White N=453, Black N=182, Asian N=87, P=.22). Health benefits from a diet high in fruit and vegetables were regarded as more motivating than skin color appearance benefits. The appearance-changing benefits of a high fruit and vegetable diet (compared to the health benefits) were relatively more important for the younger participants (Mann-Whitney U=96,263, P<.001) and for women (N=489) than for men (N=310, U=83,763, P=.01). These findings indicate that the promotion of the skin color effects of diets high in fruit and vegetables could provide additional motivation for a healthier diet. Our study indicates the broad appeal of appearance benefits from dietary fruit and vegetable (across ethnicity and socioeconomic status) and particularly amongst young adults where an inadequate diet is most prevalent.

Previous work showed high agreement in facial attractiveness preferences within and across cultures. The aims of the current study were twofold. First, we tested cross-cultural agreement in the attractiveness judgements of White Scottish and Black South African students for own- and other-ethnicity faces. Results showed significant agreement between White Scottish and Black South African observers’ attractiveness judgements, providing further evidence of strong cross-cultural agreement in facial attractiveness preferences. Second, we tested whether cross-cultural agreement is influenced by the ethnicity and/or the gender of the target group. White Scottish and Black South African observers showed significantly higher agreement for Scottish than for African faces, presumably because both groups are familiar with White European facial features, but the Scottish group are less familiar with Black African facial features. Further work investigating this discordance in cross-cultural attractiveness preferences for African faces show that Black South African observers rely more heavily on colour cues when judging African female faces for attractiveness, while White Scottish observers rely more heavily on shape cues. Results also show higher cross-cultural agreement for female, compared to male faces, albeit not significantly higher. The findings shed new light on the factors that influence cross-cultural agreement in attractiveness preferences.

Skin blood perfusion and oxygenation depends upon cardiovascular, hormonal and circulatory health in humans and provides socio-sexual signals of underlying physiology, dominance and reproductive status in some primates. We allowed participants to manipulate colour calibrated facial photographs along empirically-measured oxygenated and deoxygenated blood colour axes both separately and simultaneously, to optimise healthy appearance. Participants increased skin blood colour, particularly oxygenated, above basal levels to optimise healthy appearance. We show, therefore, that skin blood perfusion and oxygenation influence perceived health in a way that may be important to mate choice.

Background Pleomorphic dermal sarcoma (PDS) describes rare dermal‐based malignant tumours that are morphologically similar to atypical fibroxanthoma (AFX). PDS may be differentiated from AFX by the presence of one or more of the following histologic features: subcutaneous invasion, tumour necrosis, lymphovascular invasion (LVI), and/or perineural infiltration (PNI). Aims To further define the clinicopathological features, surgical management, and outcomes of PDS primary tumours. Methods and Results This study was a retrospective observational case series using a database search from 2012 to 2017. Inclusion criteria required all cases to meet the histopathologic criteria for PDS as confirmed by a specialist soft‐tissue histopathologist. A total of n = 17 cases were included with a median age of 78 years (range 66–85). All tumours were located on the head and neck, with 13/17 located on the scalp. Primary treatment was with wide local excision (WLE) in all cases. Median follow‐up was 48 months. Local recurrence occurred in 4/17 cases (24%) and distant metastasis in 2/17 cases (12%). Conclusion PDS behaves more aggressively than atypical fibroxanthoma with which it shares a biologic continuum. The optimal surgical management approach is yet to be determined.

Numerous researchers have examined the effects of skin condition, including texture and color, on the perception of health, age, and attractiveness in human faces. They have focused on facial color distribution, homogeneity of pigmentation, or skin quality. We here investigate the role of overall skin color in determining perceptions of health from faces by allowing participants to manipulate the skin portions of color-calibrated Caucasian face photographs along CIELab color axes. To enhance healthy appearance, participants increased skin redness (a*), providing additional support for previous findings that skin blood color enhances the healthy appearance of faces. Participants also increased skin yellowness (b*) and lightness (L*), suggesting a role for high carotenoid and low melanin coloration in the healthy appearance of faces. The color preferences described here resemble the red and yellow color cues to health displayed by many species of nonhuman animals.

Cyber resilience is an active research area offering a novel approach to Cyber Security. The term appeared due to the concerning number of cyber-attacks on critical infrastructure. The National Institute of Standards and Technology (NIST) developed a framework to assist organisations with techniques and approaches to improving cyber resilience. However, there are a sparsity of case studies that speak to the adoption or measurement of these novel approaches within a complex industrial control environment. This paper presents a case study analysis of a manufacturing plant assessment drawing on key themes from the NIST literature. The paper presents how well NIST constructs can be adopted to find cyber-resilient enhancement opportunities and to decide if an evaluation of the results could supply a quantitative baseline measure of an organisation’s overall resilience. Conclusions drawn show that although the framework did partially aid with the analysis process, the frameworks ease of adoption assume an organisation has a conventional cyber security foundation; NIST should make this clear within their guidance. Furthermore, the accompanying evaluation process was not sufficient to quantitatively measure the overall cyber resilience maturity for this case study.

In addition to signaling identity, sex, age, and emotional state, people frequently use facial characteristics as a basis for personality attributions. Typically, there is a high degree of consensus in the attributions made to faces. Nevertheless, the extent to which such judgments are veridical is unclear and somewhat controversial. We have examined the relationship between self-report and perceived personality using both faces of individuals and computer graphic composites. Photographs were taken of 146 men and 148 women who each also completed a self-report personality questionnaire from which scores on the big five personality dimensions were derived. In study 1, we identified a relationship between self-reported extraversion and perceived extraversion in individual faces. For male faces alone, we also found some accuracy in the perception of emotional stability and openness to experience. In study 2, composite faces were made from individuals self-reporting high and low scores on each of the five dimensions. These composites were rated for personality and attractiveness by independent raters. Discriminant analyses indicated that, controlling for attractiveness, independent ratings on congruent personality dimensions were best able to discriminate between composite faces generated from individuals high or low on the self-report dimensions of agreeableness, extraversion, and, for male faces only, emotional stability. [PUBLICATION ABSTRACT]