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"Peterson, Monique"
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Bike! : your guide to mountain biking, BMX, road and fast-track racing, C-X racing and more
Explores various aspects of biking, including mountain biking, BMX biking, road racing, and fast-track racing.
Book
\Are You Sure Sweetheart, That You Want To Be Well?\: Desire And Wellness In African-American Women's Literature
Analyzing the literature of post-Civil Rights African American women writers this dissertation asks, “What does it mean to be well?” I argue that Sherley Anne Williams, Lucille Clifton, Toni Cade Bambara, and Toni Morrison create womb-related, women-centered illness narratives in which black women actively participate in the creation and telling of their self-stories. This literary resistance to imposed definitions of illness and wellness liberates black female bodies from oppressive social frameworks based on race and gender, that are rooted in the commodification of women’s wombs during slavery, but that continues on today in the dismissal of black women’s desire and health. This project employs a reparative reading and writing practice, illness narrative theory, and black feminist and womanist thought to investigate African-American women’s literature that envisions a fuller expression of black women’s humanity, self-actualization, and self-love. These writers employ womb imagery to acknowledge and work through historic exploitation, objectification, and fragmentation of black women’s bodies. Through illness and healing narratives and womb imagery, African-American women writers create literary spaces in which they perform the radical act of re-imagining wellness that dares to prioritize black female bodies.
Dissertation
Neighborhood pollution and subjective health
In response to a call for more research documenting the association between pollution and subjective health, I use data collected by The Panel Study of Income Dynamics (PSID) between 1990 and 2007 to explore the association between neighborhood pollution and subjective health. Using regression analysis, I find that both neighborhood and individual level characteristics contribute to an association between neighborhood pollution and subjective health. Statistically, I also explore gender as a possible modifier in the proposed association and find minimal statistical support. Possible explanations for this finding are discussed in the conclusions. This research gives insight into how pollution may be associated with an individual's well-being. An addition, conclusions expand the implications of my findings on environmental justice campaigns and public health concerns.
Dissertation
Pulmonary ductal coarctation and left pulmonary artery interruption; pathology and role of neural crest and second heart field during development
In congenital heart malformations with pulmonary stenosis to atresia an abnormal lateral ductus arteriosus to left pulmonary artery connection can lead to a localised narrowing (pulmonary ductal coarctation) or even interruption We investigated embryonic remodelling and pathogenesis of this area.
Normal development was studied in WntCre reporter mice (E10.0-12.5) for neural crest cells and Nkx2.5 immunostaining for second heart field cells. Data were compared to stage matched human embryos and a VEGF120/120 mutant mouse strain developing pulmonary atresia.
Normal mouse and human embryos showed that the mid-pharyngeal endothelial plexus, connected side-ways to the 6th pharyngeal arch artery. The ventral segment formed the proximal pulmonary artery. The dorsal segment (future DA) was solely surrounded by neural crest cells. The ventral segment had a dual outer lining with neural crest and second heart field cells, while the distal pulmonary artery was covered by none of these cells. The asymmetric contribution of second heart field to the future pulmonary trunk on the left side of the aortic sac (so-called pulmonary push) was evident. The ventral segment became incorporated into the pulmonary trunk leading to a separate connection of the left and right pulmonary arteries. The VEGF120/120 embryos showed a stunted pulmonary push and a variety of vascular anomalies.
Side-way connection of the DA to the left pulmonary artery is a congenital anomaly. The primary problem is a stunted development of the pulmonary push leading to pulmonary stenosis/atresia and a subsequent lack of proper incorporation of the ventral segment into the aortic sac. Clinically, the aberrant smooth muscle tissue of the ductus arteriosus should be addressed to prohibit development of severe pulmonary ductal coarctation or even interruption of the left pulmonary artery.
Journal Article
Compliance with Results Reporting at ClinicalTrials.gov
Federal law requires that the results of many clinical trials be publicly reported at ClinicalTrials.gov in a timely manner. A review of clinical trials revealed generally poor compliance with the law, although industry-funded trials fared better than others.
The human experimentation that is conducted in clinical trials creates ethical obligations to make research findings publicly available. However, there are numerous historical examples of potentially harmful data being withheld from public scrutiny and selective publication of trial results.
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In 2000, Congress authorized the creation of the ClinicalTrials.gov registry to provide information about and access to clinical trials for persons with serious medical conditions. In 2007, Section 801 of the Food and Drug Administration Amendments Act (FDAAA) expanded this mandate by requiring sponsors of applicable clinical trials to register and report basic summary results at ClinicalTrials.gov.
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Such trials generally . . .
Journal Article
Timing and cell specificity of senescence drives postnatal lung development and injury
Senescence causes age-related diseases and stress-related injury. Paradoxically, it is also essential for organismal development. Whether senescence contributes to lung development or injury in early life remains unclear. Here, we show that lung senescence occurred at birth and decreased throughout the saccular stage in mice. Reducing senescent cells at this stage disrupted lung development. In mice (<12 h old) exposed to hyperoxia during the saccular stage followed by air recovery until adulthood, lung senescence increased particularly in type II cells and secondary crest myofibroblasts. This peaked during the alveolar stage and was mediated by the p53/p21 pathway. Decreasing senescent cells during the alveolar stage attenuated hyperoxia-induced alveolar and vascular simplification. Conclusively, early programmed senescence orchestrates postnatal lung development whereas later hyperoxia-induced senescence causes lung injury through different mechanisms. This defines the ontogeny of lung senescence and provides an optimal therapeutic window for mitigating neonatal hyperoxic lung injury by inhibiting senescence.
Senescence causes age-related diseases and stress-related injury, but it is also physiologically essential during development. Here, Yao et al. show that programmed senescence in mesenchymal cells orchestrates postnatal lung development and that neonatal hyperoxia can induce senescence, particularly in type II, Pdgfra+ mesenchymal and immune cells, during the alveolar stage, resulting in lung injury.
Journal Article
Bicuspid aortic valve formation: Nos3 mutation leads to abnormal lineage patterning of neural crest cells and the second heart field
The bicuspid aortic valve (BAV), a valve with two instead of three aortic leaflets, belongs to the most prevalent congenital heart diseases in the world, occurring in 0.5-2% of the general population. We aimed to understand how changes in early cellular contributions result in BAV formation and impact cardiovascular outflow tract development. Detailed 3D reconstructions, immunohistochemistry and morphometrics determined that, during valvulogenesis, the non-coronary leaflet separates from the parietal outflow tract cushion instead of originating from an intercalated cushion. Nos3−/− mice develop a BAV without a raphe as a result of incomplete separation of the parietal outflow tract cushion into the right and non-coronary leaflet. Genetic lineage tracing of endothelial, second heart field and neural crest cells revealed altered deposition of neural crest cells and second heart field cells within the parietal outflow tract cushion of Nos3−/− embryos. The abnormal cell lineage distributions also affected the positioning of the aortic and pulmonary valves at the orifice level. The results demonstrate that the development of the right and non-coronary leaflets are closely related. A small deviation in the distribution of neural crest and second heart field populations affects normal valve formation and results in the predominant right-non-type BAV in Nos3−/− mice.
Journal Article
GIRL FETCHES DOG. Cancer youth gets beloved Yorkie back
[JEREMY BATES Michele Klein], who had been diagnosed with malignant melanoma, left little [Hershe] with family friend Ted Kohl during a trip to London in November. Kohl had given Hershe to Michele for her 11th birthday and would often dog-sit, court papers said. \"Since Hershe has been taken from our family, my daughter has been crying herself to sleep while sleeping with Hershe's dog blanket,\" Martin Klein said in an affidavit.
Newspaper Article
S.I. DOC KILLED IN JET SKI SMASHUP
When they got there, a family member had a half-hour left on a rented Jet Ski - a jet-propelled boat ridden like a motorcycle - and offered the craft to Moretti. Moments later, he was dead. Bahamian officials said the accident is still under investigation, but family members said Moretti's watercraft collided with one ridden by his 13-year-old niece. Moretti suffered a fatal head wound, and the teen escaped with minor injuries. Moretti was remembered as a warm, concerned doctor who still made house calls and gave extra TLC to his elderly patients. \"He cared that it was somebody's grandmother,\" [Laura Moretti] said.
Newspaper Article