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In a subset of children and adolescents, SARS-CoV-2 infection induces a severe acute hyperinflammatory shock 1 termed multisystem inflammatory syndrome in children (MIS-C) at four to eight weeks after infection. MIS-C is characterized by a specific T cell expansion 2 and systemic hyperinflammation 3 . The pathogenesis of MIS-C remains largely unknown. Here we show that acute MIS-C is characterized by impaired reactivation of virus-reactive memory T cells, which depends on increased serum levels of the cytokine TGFβ resembling those that occur during severe COVID-19 (refs. 4 , 5 ). This functional impairment in T cell reactivity is accompanied by the presence of TGFβ-response signatures in T cells, B cells and monocytes along with reduced antigen-presentation capabilities of monocytes, and can be reversed by blocking TGFβ. Furthermore, T cell receptor repertoires of patients with MIS-C exhibit expansion of T cells expressing TCRVβ21.3, resembling Epstein–Barr virus (EBV)-reactive T cell clones capable of eliminating EBV-infected B cells. Additionally, serum TGFβ in patients with MIS-C can trigger EBV reactivation, which is reversible with TGFβ blockade. Clinically, the TGFβ-induced defect in T cell reactivity correlates with a higher EBV seroprevalence in patients with MIS-C compared with age-matched controls, along with the occurrence of EBV reactivation. Our findings establish a connection between SARS-CoV-2 infection and COVID-19 sequelae in children, in which impaired T cell cytotoxicity triggered by TGFβ overproduction leads to EBV reactivation and subsequent hyperinflammation. Multisystem inflammatory syndrome following SARS-CoV-2 infection results from increased serum levels of TGFβ, which impairs the reactivation of virus-specific T cells.

Antiviral CD8 + T cell immunity depends on the integration of various contextual cues, but how antigen-presenting cells (APCs) consolidate these signals for decoding by T cells remains unclear. Here, we describe gradual interferon-α/interferon-β (IFNα/β)-induced transcriptional adaptations that endow APCs with the capacity to rapidly activate the transcriptional regulators p65, IRF1 and FOS after CD4 + T cell-mediated CD40 stimulation. While these responses operate through broadly used signaling components, they induce a unique set of co-stimulatory molecules and soluble mediators that cannot be elicited by IFNα/β or CD40 alone. These responses are critical for the acquisition of antiviral CD8 + T cell effector function, and their activity in APCs from individuals infected with severe acute respiratory syndrome coronavirus 2 correlates with milder disease. These observations uncover a sequential integration process whereby APCs rely on CD4 + T cells to select the innate circuits that guide antiviral CD8 + T cell responses. Bedoui and colleagues describe a sequential process of integration of innate and CD40-delivered signals in APCs, which optimizes their capacity to drive antiviral CD8 + T cell responses.

Advanced age is the most important risk factor for severe disease or death from COVID-19, but a thorough mechanistic understanding of the molecular and cellular underpinnings is lacking. Multi-omics analysis of samples from SARS-CoV-2 infected persons aged 1 to 84 years, revealed a rewiring of type I interferon (IFN) signaling with a gradual shift from signal transducer and activator of transcription 1 (STAT1) to STAT3 activation in monocytes, CD4+ T cells and B cells with increasing age. Diversion of interferon IFN signaling was associated with increased expression of inflammatory markers, enhanced release of inflammatory cytokines, and delayed contraction of infection-induced CD4+ T cells. A shift from IFN-responsive germinal center B (GCB) cells towards CD69high GCB and atypical B cells corresponded to the formation of IgA in children while complement fixing IgG was dominant in adults. Our data provide a mechanistic basis for inflammation-prone responses to infections and associated pathology during aging.

Speckle patterns can be very promising for many applications due to their unique properties. This paper presents the possibility of numerically and experimentally formation of speckle patterns using broadband THz radiation. Strong dependence of the statistical parameters of speckles, such as size and sharpness on the parameters of the diffuser are demonstrated: the correlation length and the mean square deviation of the phase surface inhomogeneity. As the surface correlation length is increasing, the speckle size also increases and its sharpness goes down. Alternatively, the magnification of the standard deviation of the surface height leads to the speckle size diminishing and growth of the speckle sharpness. The dimensions of the experimentally formed speckles correspond to the results of numerical simulation. The possibility of utilizing formed speckle patterns for the implementation of the ghost imaging technique has been demonstrated by methods of numerical modeling.

Ice cover on lakes is subject to atmospheric forcing from above and the influence of water dynamics and heat flux from below. One characteristic example of these influences in some large lakes, such as Lake Baikal in Russia, are the giant ice rings and the associated eddies under the ice cover. In April 2020 a giant ice ring appeared in southern Baikal, and a lens-like eddy was detected below the ice. We analysed the temporal changes of ice cover using satellite images from multiple satellite missions – MODIS on Terra and Aqua, Sentinel-1 SAR, Sentinel 2 MSI, Landsat 8, PlanetScope, satellite photography from the International Space Station, and radar altimetry data from Jason-3. Satellite imagery and meteorological data show unusual temporal changes of ice colour in April 2020, which were explained by water infiltration into the ice followed by the competing influences of cold air from above and the warm eddy below the ice. Tracking of ice floe displacement also makes it possible to estimate eddy currents and their influence on the upper water layer. Multi-satellite data contribute to a better understanding of the development of ice cover in the presence of eddies, the role of eddies in horizontal and vertical heat and mass exchange, and their impact on the chemistry and biology of the lakes and on human activity.

We present mathematical and computer modelling of ghost imaging technique based on broadband pulsed radiation of terahertz spectrum range, modulated by a random phase screen. The modelling is performed in both frequency and time domains. The quality of the reconstructed images is discussed and estimated.

Changes in the external environment, market and technology require adaptability and flexibility of organizations. It is realized through system monitoring and continuous business transformation and requires changes in the system of goals and indicators, policies, business processes, organizational structure, and IT solutions. Such transformations need systemic coordination in several functional areas: strategic management, performance management, business process management, organizational design, information systems design, personnel management, knowledge management, etc. The article describes possibilities of transforming the enterprise architecture through personnel design. This method is not studied well enough as the human factor is mostly unpredictable, but it is the basis of all transformations. The developed methodology was tested at the department of Vyatka State University. As a result, the authors have identified reasons for the low efficiency of certain types of activities and described necessary intertypes for strengthening positions. The research states that intertype analysis allows to simulate the microclimate in a department or organization. Moreover, understanding intertype relationships helps to manage implicit knowledge and communication between employees, which is very important according to Kaizen.

We report on the anisotropic expansion of ultracold bosonic dysprosium gases at temperatures above quantum degeneracy and develop a quantitative theory to describe this behavior. The theory expresses the post-expansion aspect ratio in terms of temperature and microscopic collisional properties by incorporating Hartree-Fock mean-field interactions, hydrodynamic effects, and Bose-enhancement factors. Our results extend the utility of expansion imaging by providing accurate thermometry for dipolar thermal Bose gases, reducing error in expansion thermometry from tens of percent to only a few percent. Furthermore, we present a simple method to determine scattering lengths in dipolar gases, including near a Feshbach resonance, through observation of thermal gas expansion.