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"Pfaff, Donald W., 1939-"
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Man and woman : an inside story
\"The saga of sex differences in brain and behavior begins with a tiny sperm swimming toward a huge egg, to contribute its tiny Y chromosome plus its copies of the other chromosomes. Genetic, anatomic and physiologic alterations in the male ensue, making his brain and behavior different in specific respects from his sister. Brain-wise, specific cell groups develop differently in males compared to females, in some cases right after birth and in other cases at puberty. But genetics and neuroanatomy do not dominate the scene. Prenatal stress, postnatal stress and lousy treatment at puberty all can affect males and females in different ways. The upshot of all these genetic and environmental factors produces small sex differences in certain abilities and huge sex differences in feelings, in pain and in suffering. Put this all together and the reader will see that biological and cultural influences on gender roles operate at so many different levels to influence behavioral mechanisms that gender role choices are flexible, reversible and non-dichotomous, especially in modern societies.\"--Book jacket.
Book
Handbook of neuroendocrinology
Neuroendocrinology, the discipline concerned with how the nervous system controls hormonal secretion and how hormones control the brain, is pivotal to physiology and medicine. Neuroendocrinology has disclosed and underpins fundamental physiological, molecular biological and genetic principles such as the regulation of gene transcription and translation, the mechanisms of chemical neurotransmission and intracellular and systemic feedback control systems. Reproduction, growth, stress, aggression, metabolism, birth, feeding and drinking and blood pressure are some of the bodily functions that are triggered and/or controlled by neuroendocrine systems. In turn, neuroendocrine dysfunction due to genetic or other deficits can lead, for example, to infertility, impotence, precocious or delayed puberty, defective or excessive growth, obesity and anorexia, Cushing's Syndrome, hypertension or thyroid disorders. These as well as neuroendocrine tumors are some of the themes covered in the 36 chapters of the Handbook. Drafted by internationally acknowledged experts in the field, the Handbook chapters feature detailed up-to-date bibliographies as well as \"how do we know?\" call out sections that highlight the experimental or technical foundations for major concepts, principles, or methodological advances in each area. Aimed at senior undergraduate and graduate students, post-doctoral fellows and faculty in neuroscience, medicine, endocrinology, psychiatry, psychology and cognate disciplines, the Handbook of Neuroendocrinology satisfies an unmet need that will prove useful at the laboratory bench as well as in the office.
The most comprehensive up-to-date source covering basic principles, neural regulation, hormone/brain function and behavior, and neuroendocrine pathology \"How do we know?\" callout sections highlight core conceptsHeavily illustrated with over 350 figures, 4-color throughout
eBook
How the vertebrate brain regulates behavior : direct from the lab
Historically, neuroscientists often chose to work with the simplest non-mammalian species out of a fear that the mammalian brain would be too complex and would defy precise methodology. My lab's work has proven that by choosing problems and methods with care, it is possible to explain a mammalian behavior. The timing of this book reflects that it is now fifty years since I discovered hormone receptors in the brain. These hormone receptors led us to unravel the neural circuitry for a laboratory animal mating behavior and also permit us to use molecular biological techniques in the brain. The behavior explained is a social behavior, which makes it still more surprising that it has been susceptible of analysis. My lab's accomplishments typify, in one scientific story, what needs to happen as neuroscientists continue to explore mechanisms in the mammalian brain.-- Provided by publisher
Book
Oxytocin, Vasopressin and Related Peptides in the Regulation of Behavior
The mammalian neurohypophyseal peptide hormones oxytocin and vasopressin act to mediate human social behavior - they affect trust and social relationships and have an influence on avoidance responses. Describing the evolutionary roots of the effects that these neuropeptides have on behavior, this book examines remarkable parallel findings in both humans and non-human animals. The chapters are structured around three key issues: the molecular and neurohormonal mechanisms of peptides; phylogenetic considerations of their role in vertebrates; and their related effects on human behavior, social cognition and clinical applications involving psychiatric disorders such as autism. A final chapter summarizes current research perspectives and reflects on the outlook for future developments. Providing a comparative overview and featuring contributions from leading researchers, this is a valuable resource for graduate students, researchers and clinicians in this rapidly developing field.
eBook
The altruistic brain : how we are naturally good
The Altruistic Brain uses language accessible to non-scientists so as to present an elegant theory of how human beings are \"wired\" to produce altruistic behavior in the first instance. That is, it argues that unprompted, spontaneous kindness is a default behavior that comes naturally to human beings on account of evolution, irrespective of religious or cultural determinants in that direction.
eBook
Brain Arousal and Information Theory
In Brain Arousal and Information Theory, Donald Pfaff presents a daring perspective on the long-standing puzzle of what arousal is. Pfaff argues that, beneath our mental functions and emotional dispositions, a primitive neuronal system governs arousal. Employing the simple but powerful framework of information theory, Pfaff revolutionizes our understanding of arousal systems in the brain.
eBook