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Prebiotic intake reduces the waking cortisol response and alters emotional bias in healthy volunteers
Rationale
There is now compelling evidence for a link between enteric microbiota and brain function. The ingestion of probiotics modulates the processing of information that is strongly linked to anxiety and depression, and influences the neuroendocrine stress response. We have recently demonstrated that prebiotics (soluble fibres that augment the growth of indigenous microbiota) have significant neurobiological effects in rats, but their action in humans has not been reported.
Objectives
The present study explored the effects of two prebiotics on the secretion of the stress hormone, cortisol and emotional processing in healthy volunteers.
Methods
Forty-five healthy volunteers received one of two prebiotics (fructooligosaccharides, FOS, or Bimuno®-galactooligosaccharides, B-GOS) or a placebo (maltodextrin) daily for 3 weeks. The salivary cortisol awakening response was sampled before and after prebiotic/placebo administration. On the final day of treatment, participants completed a computerised task battery assessing the processing of emotionally salient information.
Results
The salivary cortisol awakening response was significantly lower after B-GOS intake compared with placebo. Participants also showed decreased attentional vigilance to negative versus positive information in a dot-probe task after B-GOS compared to placebo intake. No effects were found after the administration of FOS.
Conclusion
The suppression of the neuroendocrine stress response and the increase in the processing of positive versus negative attentional vigilance in subjects supplemented with B-GOS are consistent with previous findings of endocrine and anxiolytic effects of microbiota proliferation. Further studies are therefore needed to test the utility of B-GOS supplementation in the treatment of stress-related disorders.
Journal Article
Handbook of regional innovation and growth
\"Today, economic growth is widely understood to be conditioned by productivity increases which are, in turn, profoundly affected by innovation. This volume explores these key relationships between innovation and growth, bringing together experts from both fields to compile a unique Handbook. The Handbook considers innovation from fresh perspectives, encompassing topics such as services innovation, inward investment and innovation, creative industry innovation and green innovation. It is divided into seven sections, dealing with regional innovation and growth theory, dynamics, evolution, agglomeration, innovation worlds, innovation system institutions, and innovation governance and policy. This definitive compendium on regional innovation and growth will undoubtedly appeal to teachers, students, researchers and practitioners of innovation and growth dynamics worldwide\"--Back cover.
Book
Magnesium isotope evidence that accretional vapour loss shapes planetary compositions
The measurement of magnesium isotope ratios at improved accuracy suggests that planetary compositions result from fractionation between liquid and vapour, followed by vapour escape during accretionary growth.
Earth's volatile origins
In comparison to primitive, chondritic meteorites, which are widely thought to be the building blocks of Earth, Earth and other differentiated planetary bodies are chemically fractionated, with Earth's crust and mantle—the 'silicate Earth'—being strongly depleted in moderately volatile elements (such as lead, zinc, indium and the alkali metals). Two papers in this week's issue suggest that this difference in composition between chondritic meteorites and Earth could be a natural consequence of vapour loss from magma on the surface of growing planetesimals. Ashley Norris and Bernard Wood examined the melting processes that would have occurred during accretion on Earth and its precursor bodies and performed vaporization experiments under conditions of fixed temperature and oxygen partial pressure. They found that the pattern of volatile-element depletion in the silicate Earth is consistent with partial melting and vaporization rather than with simple accretion of a volatile-rich chondrite-like body. Remco Hin and co-authors show that differentiated planetary bodies have isotopically heavier magnesium compositions compared to chondritic meteorites, and conclude that this could be due to the isotopic fractionation between liquid and vapour, followed by vapour escape during accretionary growth of planetesimals.
It has long been recognized that Earth and other differentiated planetary bodies are chemically fractionated compared to primitive, chondritic meteorites and, by inference, the primordial disk from which they formed. However, it is not known whether the notable volatile depletions of planetary bodies are a consequence of accretion
1
or inherited from prior nebular fractionation
2
. The isotopic compositions of the main constituents of planetary bodies can contribute to this debate
3
,
4
,
5
,
6
. Here we develop an analytical approach that corrects a major cause of measurement inaccuracy inherent in conventional methods, and show that all differentiated bodies have isotopically heavier magnesium compositions than chondritic meteorites. We argue that possible magnesium isotope fractionation during condensation of the solar nebula, core formation and silicate differentiation cannot explain these observations. However, isotopic fractionation between liquid and vapour, followed by vapour escape during accretionary growth of planetesimals, generates appropriate residual compositions. Our modelling implies that the isotopic compositions of magnesium, silicon and iron, and the relative abundances of the major elements of Earth and other planetary bodies, are a natural consequence of substantial (about 40 per cent by mass) vapour loss from growing planetesimals by this mechanism.
Journal Article
Gratitude and the good life : toward a psychology of appreciation
This book provides clear and sometimes surprising answers to why gratitude is important to living well. The science of gratitude has shown much growth in the last ten years, and there is now sufficient evidence to suggest that gratitude is one of the most important components of the good life. Both correlational and experimental studies have provided support for the theory that gratitude enhances well-being.
Book
Tourist behaviour
Tourism is an inherently social phenomenon. Tourists travel with others and experience places and cultures through interacting with both familiar and unfamiliar others. This volume presents a thorough tour of the social psychological processes which underpin contemporary travel. The fascinating phenomenon of tourist behaviour deals with topics such as motivation, destination choice, travellers' on site experiences, satisfaction and learning. This book uses an array of developing and recently constructed conceptual frameworks to both synthesise what is established, and to create new insights and directions for further analysis and, ultimately, management action.
eBook
Analysis of SARS-CoV-2 antibodies in COVID-19 convalescent blood using a coronavirus antigen microarray
The current practice for diagnosis of COVID-19, based on SARS-CoV-2 PCR testing of pharyngeal or respiratory specimens in a symptomatic patient at high epidemiologic risk, likely underestimates the true prevalence of infection. Serologic methods can more accurately estimate the disease burden by detecting infections missed by the limited testing performed to date. Here, we describe the validation of a coronavirus antigen microarray containing immunologically significant antigens from SARS-CoV-2, in addition to SARS-CoV, MERS-CoV, common human coronavirus strains, and other common respiratory viruses. A comparison of antibody profiles detected on the array from control sera collected prior to the SARS-CoV-2 pandemic versus convalescent blood specimens from virologically confirmed COVID-19 cases demonstrates near complete discrimination of these two groups, with improved performance from use of antigen combinations that include both spike protein and nucleoprotein. This array can be used as a diagnostic tool, as an epidemiologic tool to more accurately estimate the disease burden of COVID-19, and as a research tool to correlate antibody responses with clinical outcomes.
COVID-19 diagnosis is commonly performed by PCR testing, however, serologic methods are more accurate and versatile for monitoring disease burden and epidemiology. Here the authors report a protein microarray with antigens from SARS-CoV-2, SARS-CoV, MERS-CoV as well as common human respiratory viruses.
Journal Article