Catalogue Search | MBRL
Are you sure you want to remove the book from the shelf?
{{itemTitle}}
532
result(s) for
"Phillips, David Peter"
Sort by:
Creativity and entrepreneurship : changing currents in education and public life
Builds upon current discourse about the expanding role of creativity and entrepreneurial studies and trends in higher education and in the public domain.
Book
Intersections of modernity and tradition: An urban planning history of Tokyo in the early Meiji period (1868-1888)
In the first two decades of the Meiji period (1868-1912) the country's leaders engaged in intense discussions about the future of the capital of Tokyo. Some leaders believed in the importance of urban beautification, while others regarded changes in urban infrastructure and services as essential to maintenance and growth of the city. Many of the proposed changes were cloaked in the language of progress. This work examines the course taken by urban leaders of the first decades of the Meiji period in establishing planning policy. This investigation depends heavily on planning documents, transcripts of planning committees, and on architectural and urban design data from completed urban improvement projects in Meiji Tokyo. My research focuses on two issues, (1) the extent to which the efforts of Japanese leaders focused the country on the goal of modernization, and (2) the extent to which efforts to achieve bunmei kaika, or cultural enlightenment, were superficial. My aim in this study is to demonstrate how the concepts of modernity and the struggle to develop a modern urban structure altered previous notions of cities and city planning practices. In summarizing my results, I review the debates among historians in reconstructing the developments in Tokyo's planning history, and conclude that poor articulation of planning policy in the first decades of the Meiji period reflects a lack of consensus among Meiji leaders about the definition and course of modernization. Rather than reject traditional approaches to planning, urban leaders eventually incorporated these approaches into their new planning methodologies. Modernity in the Japanese context, consequently, did not require dismantling preexisting urban structures. Instead, it represented a marriage of the political motivations of the country's leaders with the modern urban needs for improved transportation networks and zoning mechanisms. Exposure of the political system to popular opinion entailed the shifting of planning discourse from the theoretical to the practical realm, as well as from the private to the public realm.
Dissertation
Handbook on agriculture biotechnology and development
This title provides a diverse, but concentrated, global perspective on biotechnology applications to plant agriculture. Readers gain rich insights into specific aspects of agbiotech, anchored in an overarching governance framework that determines trade and regulation of agbiotech processes.
Book
UPSIDES OF THE OFR David Phillips and Peter Wyman
*Requirements stem directly from the UK's company law review.
Newspaper Article
G2: Notes & queries: How to put the froth in your latte
Many electric espresso machine manufacturers, including De Longhi, Krups, Siemens and Jura, provide just such a device for taking milk straight from the bottle or jug, instantly heating it and delivering a frothy stream directly into the cup.
Newspaper Article
The Human Gene Mutation Database (HGMD®): optimizing its use in a clinical diagnostic or research setting
The Human Gene Mutation Database (HGMD®) constitutes a comprehensive collection of published germline mutations in nuclear genes that are thought to underlie, or are closely associated with human inherited disease. At the time of writing (June 2020), the database contains in excess of 289,000 different gene lesions identified in over 11,100 genes manually curated from 72,987 articles published in over 3100 peer-reviewed journals. There are primarily two main groups of users who utilise HGMD on a regular basis; research scientists and clinical diagnosticians. This review aims to highlight how to make the most out of HGMD data in each setting.
Journal Article
The Human Gene Mutation Database: building a comprehensive mutation repository for clinical and molecular genetics, diagnostic testing and personalized genomic medicine
The Human Gene Mutation Database (HGMD
®
) is a comprehensive collection of germline mutations in nuclear genes that underlie, or are associated with, human inherited disease. By June 2013, the database contained over 141,000 different lesions detected in over 5,700 different genes, with new mutation entries currently accumulating at a rate exceeding 10,000 per annum. HGMD was originally established in 1996 for the scientific study of mutational mechanisms in human genes. However, it has since acquired a much broader utility as a central unified disease-oriented mutation repository utilized by human molecular geneticists, genome scientists, molecular biologists, clinicians and genetic counsellors as well as by those specializing in biopharmaceuticals, bioinformatics and personalized genomics. The public version of HGMD (
https://www.hgmd.cf.ac.uk
) is freely available to registered users from academic institutions/non-profit organizations whilst the subscription version (HGMD Professional) is available to academic, clinical and commercial users under license via BIOBASE GmbH.
Journal Article
The Human Gene Mutation Database: towards a comprehensive repository of inherited mutation data for medical research, genetic diagnosis and next-generation sequencing studies
The Human Gene Mutation Database (HGMD
®
) constitutes a comprehensive collection of published germline mutations in nuclear genes that underlie, or are closely associated with human inherited disease. At the time of writing (March 2017), the database contained in excess of 203,000 different gene lesions identified in over 8000 genes manually curated from over 2600 journals. With new mutation entries currently accumulating at a rate exceeding 17,000 per annum, HGMD represents de facto the central unified gene/disease-oriented repository of heritable mutations causing human genetic disease used worldwide by researchers, clinicians, diagnostic laboratories and genetic counsellors, and is an essential tool for the annotation of next-generation sequencing data. The public version of HGMD (
http://www.hgmd.org
) is freely available to registered users from academic institutions and non-profit organisations whilst the subscription version (HGMD Professional) is available to academic, clinical and commercial users under license via QIAGEN Inc.
Journal Article
Mutational signatures associated with tobacco smoking in human cancer
Tobacco smoking increases the risk of at least 17 classes of human cancer. We analyzed somatic mutations and DNA methylation in 5243 cancers of types for which tobacco smoking confers an elevated risk. Smoking is associated with increased mutation burdens of multiple distinct mutational signatures, which contribute to different extents in different cancers. One of these signatures, mainly found in cancers derived from tissues directly exposed to tobacco smoke, is attributable to misreplication of DNA damage caused by tobacco carcinogens. Others likely reflect indirect activation of DNA editing by APOBEC cytidine deaminases and of an endogenous clocklike mutational process. Smoking is associated with limited differences in methylation. The results are consistent with the proposition that smoking increases cancer risk by increasing the somatic mutation load, although direct evidence for this mechanism is lacking in some smoking-related cancer types.
Journal Article