Catalogue Search | MBRL
Are you sure you want to remove the book from the shelf?
{{itemTitle}}
5,567
result(s) for
"Phillips, Jennifer"
Sort by:
Walking on eggshells
After a psychotic episode lands sixteen-year-old Kai Lum in a psychiatric hospital, he struggles to reclaim his life and pursue his culinary dreams while grappling with medication side effects, family pressures, and wavering friendships, as he questions the reality of the voices he hears.
BOOK
On the existence and functionality of topologically associating domains
Genomes across a wide range of eukaryotic organisms fold into higher-order chromatin domains. Topologically associating domains (TADs) were originally discovered empirically in low-resolution Hi-C heat maps representing ensemble average interaction frequencies from millions of cells. Here, we discuss recent advances in high-resolution Hi-C, single-cell imaging experiments, and functional genetic studies, which provide an increasingly complex view of the genome’s hierarchical structure–function relationship. On the basis of these new findings, we update the definitions of distinct classes of chromatin domains according to emerging knowledge of their structural, mechanistic and functional properties.
Recent advances in Hi-C, single-cell imaging and functional genetic studies warrant discussion on the functional relevance of topologically associating domains (TADs) and other classes of chromatin domains.
Journal Article
The irresponsible traveller : tales of scrapes and narrow escapes
Featuring tales of sticky situations from famous travel writers and celebrities, The Irresponsible Traveller celebrates Bradt's 40th anniversary.
Book
To oldly go : tales of intrepid travel by the over-60s
\"A brand new collection of remarkable travel tales from 'Silver Travellers'. Dervla Murphy travelling in Havana at the age of 74, Matthew Parris swimming the Thames at 60, and Colin Thubron climbing the last stronghold of the Assassins in his 60s are among the writers recounting their adventures, often defying expectations - and the odds - and going outside their comfort zone to take a less-travelled path in later life. Published with participation from the Silver Travel Advisor, this single volume brings together contributions - some original, some previously published - from independent-minded souls whose experiences have been entertaining, amusing, thrilling, and even a little irresponsible. Other contributors include Roger Bray, 'Green Goddess' Diana Moran and our very own Hilary Bradt.\"--Wheelers.co.nz.
Book
Zebrafish models in translational research: tipping the scales toward advancements in human health
Advances in genomics and next-generation sequencing have provided clinical researchers with unprecedented opportunities to understand the molecular basis of human genetic disorders. This abundance of information places new requirements on traditional disease models, which have the potential to be used to confirm newly identified pathogenic mutations and test the efficacy of emerging therapies. The unique attributes of zebrafish are being increasingly leveraged to create functional disease models, facilitate drug discovery, and provide critical scientific bases for the development of new clinical tools for the diagnosis and treatment of human disease. In this short review and the accompanying poster, we highlight a few illustrative examples of the applications of the zebrafish model to the study of human health and disease.
Journal Article
The new frontline: exploring the links between moral distress, moral resilience and mental health in healthcare workers during the COVID-19 pandemic
Background
Global health crises, such as the COVID-19 pandemic, confront healthcare workers (HCW) with increased exposure to potentially morally distressing events. The pandemic has provided an opportunity to explore the links between moral distress, moral resilience, and emergence of mental health symptoms in HCWs.
Methods
A total of 962 Canadian healthcare workers (88.4% female, 44.6 + 12.8 years old) completed an online survey during the first COVID-19 wave in Canada (between April 3rd and September 3rd, 2020). Respondents completed a series of validated scales assessing moral distress, perceived stress, anxiety, and depression symptoms, and moral resilience. Respondents were grouped based on exposure to patients who tested positive for COVID-19. In addition to descriptive statistics and analyses of covariance, multiple linear regression was used to evaluate if moral resilience moderates the association between exposure to morally distressing events and moral distress. Factors associated with moral resilience were also assessed.
Findings
Respondents working with patients with COVID-19 showed significantly more severe moral distress, anxiety, and depression symptoms (F
>
5.5,
p
<
.020), and a higher proportion screened positive for mental disorders (Chi-squared > 9.1,
p
= .002), compared to healthcare workers who were not. Moral resilience moderated the relationship between exposure to potentially morally distressing events and moral distress (
p
< .001); compared to those with higher moral resilience, the subgroup with the lowest moral resilience had a steeper cross-sectional worsening in moral distress as the frequency of potentially morally distressing events increased. Moral resilience also correlated with lower stress, anxiety, and depression symptoms (
r
>
.27,
p
< .001). Factors independently associated with stronger moral resilience included: being male, older age, no mental disorder diagnosis, sleeping more, and higher support from employers and colleagues (B [0.02, |-0.26|].
Interpretation
Elevated moral distress and mental health symptoms in healthcare workers facing a global crisis such as the COVID-19 pandemic call for the development of interventions promoting moral resilience as a protective measure against moral adversities.
Journal Article
Urban sparrows respond to a sexually selected trait with increased aggression in noise
Animals modify acoustic communication signals in response to noise pollution, but consequences of these modifications are unknown. Vocalizations that transmit best in noise may not be those that best signal male quality, leading to potential conflict between selection pressures. For example, slow paced, narrow bandwidth songs transmit better in noise but are less effective in mate choice and competition than fast paced, wide bandwidth songs. We test the hypothesis that noise affects response to song pace and bandwidth in the context of competition using white-crowned sparrows (
Zonotrichia leucophrys
). We measure male response to song variation along a gradient of ambient noise levels in San Francisco, CA. We find that males discriminate between wide and narrow bandwidth songs but not between slow and fast paced songs. These findings are biologically relevant because songs in noisy areas tend to have narrow bandwidths. Therefore, this song phenotype potentially increases transmission distance in noise, but elicits weaker responses from competitors. Further, we find that males respond more strongly to stimuli in noisier conditions, supporting the ‘urban anger’ hypothesis. We suggest that noise affects male responsiveness to song, possibly leading to more territorial conflict in urban areas.
Journal Article
Effects of Urbanization and Landscape on Gut Microbiomes in White-Crowned Sparrows
Habitats are changing rapidly around the globe and urbanization is one of the primary drivers. Urbanization changes food availability, environmental stressors, and the prevalence of disease for many species. These changes can lead to divergence in phenotypic traits, including behavioral, physiological, and morphological features between urban and rural populations. Recent research highlights that urbanization is also changing the gut microbial communities found in a diverse group of host species. These changes have not been uniform, leaving uncertainty as to how urban habitats are shaping gut microbial communities. To better understand these effects, we investigated the gut bacterial communities of White-Crowned Sparrow (Zonotrichia leucophrys) populations along an urbanization gradient in the San Francisco Bay area. We examined how gut bacterial communities vary with the local environment and host morphological characteristics. We found direct effects of environmental factors, including urban noise levels and territory land cover, as well as indirect effects through body size and condition, on alpha and beta diversity of gut microbial communities. We also found that urban and rural birds’ microbiomes differed in which variables predicted their diversity, with urban communities driven by host morphology, and rural communities driven by environmental factors. Elucidating these effects provides a better understanding of how urbanization affects wild avian physiology.
Journal Article