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"Phillips, R. J."
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The Electric and Magnetic Field Instrument Suite and Integrated Science (EMFISIS) on RBSP
The Electric and Magnetic Field Instrument and Integrated Science (EMFISIS) investigation on the NASA Radiation Belt Storm Probes (now named the Van Allen Probes) mission provides key wave and very low frequency magnetic field measurements to understand radiation belt acceleration, loss, and transport. The key science objectives and the contribution that EMFISIS makes to providing measurements as well as theory and modeling are described. The key components of the instruments suite, both electronics and sensors, including key functional parameters, calibration, and performance, demonstrate that EMFISIS provides the needed measurements for the science of the RBSP mission. The EMFISIS operational modes and data products, along with online availability and data tools provide the radiation belt science community with one the most complete sets of data ever collected.
Journal Article
Crustal-lithospheric structure and continental extrusion of Tibet
Crustal shortening and thickening to c. 70-85 km in the Tibetan Plateau occurred both before and mainly after the c. 50 Ma India-Asia collision. Potassic-ultrapotassic shoshonitic and adakitic lavas erupted across the Qiangtang (c. 50-29 Ma) and Lhasa blocks (c. 30-10 Ma) indicate a hot mantle, thick crust and eclogitic root during that period. The progressive northward underthrusting of cold, Indian mantle lithosphere since collision shut off the source in the Lhasa block at c. 10 Ma. Late Miocene-Pleistocene shoshonitic volcanic rocks in northern Tibet require hot mantle. We review the major tectonic processes proposed for Tibet including \"rigid-block', continuum and crustal flow as well as the geological history of the major strike-slip faults. We examine controversies concerning the cumulative geological offsets and the discrepancies between geological, Quaternary and geodetic slip rates. Low present-day slip rates measured from global positioning system and InSAR along the Karakoram and Altyn Tagh Faults in addition to slow long-term geological rates can only account for limited eastward extrusion of Tibet since Mid-Miocene time. We conclude that despite being prominent geomorphological features sometimes with wide mylonite zones, the faults cut earlier formed metamorphic and igneous rocks and show limited offsets. Concentrated strain at the surface is dissipated deeper into wide ductile shear zones.
Journal Article
The 2009 L'Aquila earthquake (central Italy): A source mechanism and implications for seismic hazard
We use InSAR and body‐wave seismology to determine independent source parameters for the 6th April 2009 Mw 6.3 L'Aquila earthquake and confirm that the earthquake ruptured a SW‐dipping normal fault with ∼0.6–0.8 m slip. The causative Paganica fault had been neglected relative to other nearby range‐frontal faults, partly because it has a subdued geomorphological expression in comparison with these faults. The L'Aquila earthquake occurred in an area with a marked seismic deficit relative to geodetically determined strain accumulation. We use our source model to calculate stress changes on nearby faults produced by the L'Aquila earthquake and we find that several of these faults have been brought closer to failure.
Journal Article
High-resolution 3D imaging and topological mapping of the lymph node conduit system
The conduit network is a hallmark of lymph node microanatomy, but lack of suitable imaging technology has prevented comprehensive investigation of its topology. We employed an extended-volume imaging system to capture the conduit network of an entire murine lymph node (comprising over 280,000 segments). The extensive 3D images provide a comprehensive overview of the regions supplied by conduits, including perivascular sleeves and distinctive \"follicular reservoirs\" within B cell follicles, surrounding follicular dendritic cells. A 3D topology map of conduits within the T-cell zone showed homogeneous branching, but conduit density was significantly higher in the superficial T-cell zone compared with the deep zone, where distances between segments are sufficient for T cells to lose contact with fibroblastic reticular cells. This topological mapping of the conduit anatomy can now aid modeling of its roles in lymph node function, as we demonstrate by simulating T-cell motility in the different T-cell zones.
Journal Article
Extracellular matrix and cellular senescence in venous leg ulcers
High prevalence of non-healing chronic wounds contributes to a huge healthcare burden across the world. Early treatment interventions for non-healing wounds are vital. It was previously shown that accumulation of 15% or more of senescent cells in a chronic wound edge is an indicator that the wound is unlikely to heal. However, determining the presence of senescent cells would require invasive procedures such as tissue biopsies to be taken. In this study, we found a strong correlation between decreased collagen area and presence of senescent cells in human chronic wounds i.e. venous leg ulcer (VLU), diabetic foot ulcer (DFU) and pressure ulcer (PRU). We also report that the lowest collagen levels were found in VLU patients less than 60 years of age, with a persistent wound of > 24 months. Elevated levels of senescent cells were also found in VLU of males. Second harmonic imaging of collagen at the edge of chronic wounds with a handheld multiphoton device could be used to predict the number of senescent cells, indicating if the wound is on a healing trajectory or not. Our data support the use of collagen imaging in cutaneous wound assessment for a faster and non-invasive method to predict cellular senescence and determining wound trajectory of healing.
Journal Article