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result(s) for
"Piddock, Claire"
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Math Masters: Dots, Plots, and Histograms
\"Data, data, everywhere...in newspapers, on websites, even in television commercials. Data is shown in different kinds of graphs. Learning about them helps you become a wise consumer. Get the inside scoop about interpreting data and graphs!\" (Math Masters: Dots, Plots, and Histograms)
Journal Article
Position and direction
Introduces the concepts of position and direction, and describes how they are used to indicate an object's position in space and how they are useful when reading a map.
Book
Math Masters: All About Area
\"Be square! Yes, square units are what you need to measure area. Whether you're painting a room, planting a garden, or wrapping a gift, you will need to know how much surface you need to cover. Look inside to discover how to find area.\" (Math Masters: All About Area)
Journal Article
Math Masters: Mixed Numbers
\"What is it about these mixed up numbers and fractions acting improperly? Look inside to straighten out your thinking about mixed numbers in math. You will see how easy it is to work with these numbers once you get to know them.\" (Math Masters: Mixed Numbers)
Journal Article
Math Masters: Patterns
\"Day, night, day, night...That's a pattern. So is part of the chant 'Two, four, six, eight, who do we appreciate?' We appreciate number patterns, of course! Discover what makes patterns so cool, learn their rules, and uncover the places you can find them in nature.\" (Math Masters: Patterns)
Journal Article
Genome-wide association study identifies risk loci for progressive chronic lymphocytic leukemia
Prognostication in patients with chronic lymphocytic leukemia (CLL) is challenging due to heterogeneity in clinical course. We hypothesize that constitutional genetic variation affects disease progression and could aid prognostication. Pooling data from seven studies incorporating 842 cases identifies two genomic locations associated with time from diagnosis to treatment, including 10q26.13 (rs736456, hazard ratio (HR) = 1.78, 95% confidence interval (CI) = 1.47–2.15;
P
= 2.71 × 10
−9
) and 6p (rs3778076, HR = 1.99, 95% CI = 1.55–2.55;
P
= 5.08 × 10
−8
), which are particularly powerful prognostic markers in patients with early stage CLL otherwise characterized by low-risk features. Expression quantitative trait loci analysis identifies putative functional genes implicated in modulating B-cell receptor or innate immune responses, key pathways in CLL pathogenesis. In this work we identify rs736456 and rs3778076 as prognostic in CLL, demonstrating that disease progression is determined by constitutional genetic variation as well as known somatic drivers.
The clinical course of chronic lymphocytic leukaemia (CLL) is variable and difficult to predict. Here, the authors conduct a genome wide association study meta-analysis for time to first treatment in CLL patients and report two loci associating with progressive disease.
Journal Article
Biallelic TET2 mutations confer sensitivity to 5′-azacitidine in acute myeloid leukemia
Precision medicine can significantly improve outcomes for patients with cancer, but implementation requires comprehensive characterization of tumor cells to identify therapeutically exploitable vulnerabilities. Here, we describe somatic biallelic TET2 mutations in an elderly patient with acute myeloid leukemia (AML) that was chemoresistant to anthracycline and cytarabine but acutely sensitive to 5'-azacitidine (5'-Aza) hypomethylating monotherapy, resulting in long-term morphological remission. Given the role of TET2 as a regulator of genomic methylation, we hypothesized that mutant TET2 allele dosage affects response to 5'-Aza. Using an isogenic cell model system and an orthotopic mouse xenograft, we demonstrate that biallelic TET2 mutations confer sensitivity to 5'-Aza compared with cells with monoallelic mutations. Our data argue in favor of using hypomethylating agents for chemoresistant disease or as first-line therapy in patients with biallelic TET2-mutated AML and demonstrate the importance of considering mutant allele dosage in the implementation of precision medicine for patients with cancer.
Journal Article
The ‘unified airway’: the RCPCH care pathway for children with asthma and/or rhinitis
Aims The Royal College of Paediatrics and Child Health (RCPCH) Science and Research Department was commissioned by the Department of Health to develop national care pathways for children with allergies: the asthma/rhinitis care pathway is the third such pathway. Asthma and rhinitis have been considered together. These conditions co-exist commonly, have remarkably similar immuno-pathology and an integrated management approach benefits symptom control. Method The asthma/rhinitis pathway was developed by a multidisciplinary working group and was based on a comprehensive review of evidence. The pathway was reviewed by a broad group of stakeholders including the public and was approved by the Allergy Care Pathways Project Board and the RCPCH Clinical Standards Committee. Results The pathway entry points are defined by symptom type and severity at presentation. Acute severe rhinitis and life-threatening asthma are presented as distinct entry routes to the pathway, recognising that initial care of these conditions requires presentation-specific treatments. However, the pathway emphasises that ideal long term care should take account of both conditions in order to achieve maximal improvements in disease control and quality of life. Conclusions The pathway recommends that acute presentations of asthma and/or rhinitis should be treated separately. Where both conditions exist, ongoing management should address the upper and lower airways. The authors recommend that this pathway is implemented locally by a multidisciplinary team (MDT) with a focus on creating networks. The MDT within these networks should work with patients to develop and agree on care plans that are age and culturally appropriate.
Journal Article