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CYGNO is a project realising a cubic meter demonstrator to study the scalability of the performance of the optical approach for the readout of large-volume, GEM-equipped TPC. This is part of the CYGNUS proto-collaboration which aims at constructing a network of underground observatories for directional Dark Matter search. The combined use of high-granularity sCMOS and fast sensors for reading out the light produced in GEM channels during the multiplication processes was shown to allow on one hand to reconstruct 3D direction of the tracks, offering accurate energy measurements and sensitivity to the source directionality and, on the other hand, a high particle identification capability very useful to distinguish nuclear recoils. Results of the performed R&D and future steps toward a 30-100 cubic meter experiment will be presented.

The performances of an optical readout of Time Projection Chambers (TPCs) with multiple Gas Electron Multipliers (GEMs) amplification stages are presented. The detector is characterized by using 55Fe photons converting inside a 7 litre sensitive volume detector in different electric field configurations. This prototype is developed as part of the R&D for the CYGNO project for an application to direct Dark Matter search by detection of tracks of nuclear recoils in the gas within the keV energy range.

In Particle Therapy (PT) accelerated charged particles and light ions are used for treating tumors. One of the main limitation to the precision of PT is the emission of secondary particles due to the beam interaction with the patient: secondary emitted neutrons can release a significant dose far from the tumor. Therefore, a precise characterization of their flux, production energy and angle distribution is eagerly needed in order to improve the Treatment Planning Systems (TPS) codes. The principal aim of the MONDO (MOnitor for Neutron Dose in hadrOntherapy) project is the development of a tracking device optimized for the detection of fast and ultra-fast secondary neutrons emitted in PT. The detector consists of a matrix of scintillating square fibres coupled with a CMOS-based readout. Here, we present the characterization of the detector tracker prototype and CMOS-based digital SPAD (Single Photon Avalanche Diode) array sensor tested with protons at the Beam Test Facility (Frascati, Italy) and at the Proton Therapy Centre (Trento, Italy), respectively.

The goal of the CYGNO project is to deploy at Laboratori Nazionali del Gran Sasso (LNGS) an high resolution Time Projection Chamber (TPC) with Gas Electron Multipliers (GEMs) amplification and optical 3D readout of an Helium/Fluorine based gas mixture for directional Dark Matter (DM) searches at low 1-10 GeV WIMP masses. The determination of the incoming direction of WIMP particles can in fact offer not only additional handles for discrimination of the annoying backgrounds, but especially an unique key for a positive, unambiguous identification of a DM signal.

The dual-readout approach, which allows an event-by-event measurement of the electromagnetic shower fraction, was originally demonstrated with the DREAM sampling calorimeter. This approach can be extended to homogeneous detectors like crystals if Cherenkov and scintillation light can be separated. In this paper we present several methods we developed for distinguishing the two components in PWO and BGO based calorimters and the results obtained.

A radio-guided surgery technique exploiting β− emitters is under development. It aims at a higher target-to-background activity ratio implying both a smaller radiopharmaceutical activity and the possibility of extending the technique to cases with a large uptake of surrounding healthy organs. Such technique requires a dedicated intraoperative probe detecting β- radiation. A first prototype has been developed relying on the low density and high light yield of the diphenylbutadiene doped para-therphenyl organic scintillator. The scintillation light produced in a cylindrical crystal, 5 mm in diameter and 3 mm in height, is guided to a photo-multiplier tube by optical fibres. The custom readout electronics is designed to optimize its usage in terms of feedback to the surgeon, portability and remote monitoring of the signal. Tests show that with a radiotracer activity comparable to those administered for diagnostic purposes the developed probe can detect a 0.1 ml cancerous residual of meningioma in a few seconds.

Particle therapy is a technique that uses accelerated charged ions for cancer treatment and combines a high irradiation precision with a high biological effectiveness in killing tumor cells [1]. Informations about the secondary particles emitted in the interaction of an ion beam with the patient during a treatment can be of great interest in order to monitor the dose deposition. For this purpose an experiment at the HIT (Heidelberg Ion-Beam Therapy Center) beam facility has been performed in order to measure fluxes and emission profiles of secondary particles produced in the interaction of therapeutic beams with a PMMA target. In this contribution some preliminary results about the emission profiles and the energy spectra of the detected secondaries will be presented.

Large-mass arrays of bolometers proved to be good detectors for neutrinoless double beta decay (0 ν DBD) and dark matter searches. CUORE and LUCIFER are bolometric 0 ν DBD experiments that will start to take data in 2015 at Laboratori Nazionali del Gran Sasso in Italy. The sensitivity of CUORE could be increased by removing the background due to α particles, by detecting the small amount of Čerenkov light ( ∼ 100 eV) emitted by the β s’ signal and not by α s. LUCIFER could be extended to detect also dark matter, provided that the background from β / γ particles ( ∼ 100 eV of scintillation light) is discriminated from nuclear recoils of about 10 keV energy (no light). We have recently started to develop light detectors for CUORE, LUCIFER and similar bolometric experiments. The aim is to obtain detectors with an active area of 5 × 5 cm 2 (the face of bolometric crystals), operating at 10 mK, and with an energy resolution at the baseline below 20 eV RMS. We have chosen to develop phonon-mediated detectors with KID sensors. We are currently testing the first prototypes.

Finding new ways to fight cancer is essential to increase the patients life expectancy. This paper reports the latest results of the project CHIRONE finalized to increase the potential of the Radio Guided Surgery through the use of β− emitting radio-tracers and β− probes. This innovation could overcome the present main limiting factor represented by a diffuse background due to the high penetration power of the gamma radiation used. We created a prototype of β− probe and in this paper we report measures of photon efficiency, acquired with commercial photons sources. Then we estimated the signal and background rates in realistic cases of meningioma through a simulation. The device is able to detect residuals of 0.1 ml in 1 s with an administered activity less than 3 MBq/kg.

The SuperB project is an asymmetric e+e− accelerator of 1036 cm−2s−1 luminosity, capable of collecting a 50–75 ab−1 data sample in five years of running. The SuperB electromagnetic calorimeter (EMC) provides energy and direction measurement of photons and electrons and identification versus other charged particles for electrons. A matrix of 25 LYSO crystals has been tested at the Beam Test Facility at Frascati in May 2011 at energies between 100 MeV and 500 MeV. Results from this test will be presented. Design and Monte Carlo studies for the general EMC system will also be presented.