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Long COVID has been linked to a decline in physical activity and functional capacity. However, it remains unclear which physical symptoms are associated with specific aspects of movement behaviors and functional capacity. We aimed to investigate the associations of fatigue, dyspnea, post-exertional malaise, myalgia, and the co-occurrence of symptoms with movement behaviors and functional capacity in individuals with Long COVID. A cross-sectional multicenter study was conducted. Questionnaires were used to assess fatigue, dyspnea, post-exertional malaise, and myalgia. Accelerometry was employed to assess sedentary time, steps per day, light physical activity, and moderate-to-vigorous physical activity. The six-minute walk test, 30-s chair stand test, and timed up and go were used to assess functional capacity. One hundred and two community-dwelling individuals who had been living with Long COVID for 15 ± 10 months participated in the study. Fatigue, post-exertional malaise, and the co-occurrence of physical symptoms showed a negative association with step count, while post-exertional malaise was also negatively associated with moderate-to-vigorous physical activity. Dyspnea showed a negative association with the functional score, including all tests. Our findings suggest that fatigue, post-exertional malaise, and the co-occurrence of physical symptoms are negatively associated with physical activity, while dyspnea is negatively associated with functional capacity in individuals with Long COVID.

To date, more than 2400 valid fish species have been recorded in the Amazon basin. However, some regions remain poorly documented. This is the case in the Beni basin and in particular in one of its main sub-basins, the Tuichi, an Andean foothills rivers flowing through the Madidi National Park in the Bolivian Amazonia. The knowledge of its ichthyological diversity is, however, essential for the management and protection of aquatic ecosystems, which are threatened by the development of infrastructures (dams, factories and cities), mining and deforestation. Environmental DNA (eDNA) has been relatively little used so far in the Amazon basin. We sampled eDNA from water in 34 sites in lakes and rivers in the Beni basin including 22 sites in the Tuichi sub-basin, during the dry season. To assess the biogeographical patterns of the amazonian ichthyofauna, we implemented a metabarcoding approach using two pairs of specific primers designed and developed in our laboratory to amplify two partially overlapping CO1 fragments, one of 185bp and another of 285bp. We detected 252 fish taxa (207 at species level) among which 57 are newly identified for the Beni watershed. Species compositions are significantly different between lakes and rivers but also between rivers according to their hydrographic rank and altitude. Furthermore, the diversity patterns are related to the different hydro-ecoregions through which the Tuichi flows. The eDNA approach makes it possible to identify and complete the inventory of the ichthyofauna in this still poorly documented Amazon basin. However, taxonomic identification remains constrained by the lack of reference barcodes in public databases and does not allow the assignment of all OTUs. Our results can be taken into account in conservation and management strategies and could serve as a baseline for future studies, including on other Andean tributaries.

Rift Valley fever (RVF), a mosquito-borne disease affecting ruminants and humans, is one of the most important viral zoonoses in Africa. The objective of the present study was to develop a geographic knowledge-based method to map the areas suitable for RVF amplification and RVF spread in four East African countries, namely, Kenya, Tanzania, Uganda and Ethiopia, and to assess the predictive accuracy of the model using livestock outbreak data from Kenya and Tanzania. Risk factors and their relative importance regarding RVF amplification and spread were identified from a literature review. A numerical weight was calculated for each risk factor using an analytical hierarchy process. The corresponding geographic data were collected, standardized and combined based on a weighted linear combination to produce maps of the suitability for RVF transmission. The accuracy of the resulting maps was assessed using RVF outbreak locations in livestock reported in Kenya and Tanzania between 1998 and 2012 and the ROC curve analysis. Our results confirmed the capacity of the geographic information system-based multi-criteria evaluation method to synthesize available scientific knowledge and to accurately map (AUC = 0.786; 95% CI [0.730-0.842]) the spatial heterogeneity of RVF suitability in East Africa. This approach provides users with a straightforward and easy update of the maps according to data availability or the further development of scientific knowledge.

Several maternal and birth characteristics have been reported to be associated with an increased risk of many childhood cancers. Our goal was to evaluate the risk of childhood embryonal solid tumors in relation to pre- and perinatal characteristics. A case-cohort study was performed using two population-based datasets, which were linked through R software. Tumors were classified as central nervous system (CNS) or non-CNS-embryonal (retinoblastoma, neuroblastoma, renal tumors, germ cell tumors, hepatoblastoma and soft tissue sarcoma). Children aged <6 years were selected. Adjustments were made for potential confounders. Odds ratios (OR) with 95% confidence intervals (CI) were computed by unconditional logistic regression analysis using SPSS. Males, high maternal education level, and birth anomalies were independent risk factors. Among children diagnosed older than 24 months of age, cesarean section (CS) was a significant risk factor. Five-minute Apgar ≤8 was an independent risk factor for renal tumors. A decreasing risk with increasing birth order was observed for all tumor types except for retinoblastoma. Among children with neuroblastoma, the risk decreased with increasing birth order (OR = 0.82 (95% CI 0.67-1.01)). Children delivered by CS had a marginally significantly increased OR for all tumors except retinoblastoma. High maternal education level showed a significant increase in the odds for all tumors together, CNS tumors, and neuroblastoma. This evidence suggests that male gender, high maternal education level, and birth anomalies are risk factors for childhood tumors irrespective of the age at diagnosis. Cesarean section, birth order, and 5-minute Apgar score were risk factors for some tumor subtypes.

Negative-pressure pulmonary edema (NPPE) is a rare cause of noncardiogenic pulmonary edema, which usually presents postoperatively. Its pathophysiology is mostly described as a profound negative intrathoracic pressure caused by an airway obstruction such as laryngospasm, which may occur during extubation. But, there are other hypotheses about it, such as catecholamines release causing an elevated hydrostatic pressure in the cardiopulmonary circuit and, consequently, a major capillary leak to the interstitium. Its natural course varies, from prompt recovery to intensive care unit escalation and prolonged mechanical ventilation. Although anesthesiologists often detect this condition, this case's objective is to bring awareness of this condition to internists as a potential differential diagnosis for hypoxia in the postoperative setting.

Unexpected pathogen transmission between animals, humans and their shared environments can impact all aspects of society. The Tripartite organisations—the Food and Agriculture Organization of the United Nations (FAO), the World Health Organization (WHO), and the World Organisation for Animal Health (WOAH)—have been collaborating for over two decades. The inclusion of the United Nations Environment Program (UNEP) with the Tripartite, forming the ‘Quadripartite’ in 2021, creates a new and important avenue to engage environment sectors in the development of additional tools and resources for One Health coordination and improved health security globally. Beginning formally in 2010, the Tripartite set out strategic directions for the coordination of global activities to address health risks at the human-animal-environment interface. This paper highlights the historical background of this collaboration in the specific area of health security, using country examples to demonstrate lessons learnt and the evolution and pairing of Tripartite programmes and processes to jointly develop and deliver capacity strengthening tools to countries and strengthen performance for iterative evaluations. Evaluation frameworks, such as the International Health Regulations (IHR) Monitoring and Evaluation Framework, the WOAH Performance of Veterinary Services (PVS) Pathway and the FAO multisectoral evaluation tools for epidemiology and surveillance, support a shared global vision for health security, ultimately serving to inform decision making and provide a systematic approach for improved One Health capacity strengthening in countries. Supported by the IHR-PVS National Bridging Workshops and the development of the Tripartite Zoonoses Guide and related operational tools, the Tripartite and now Quadripartite, are working alongside countries to address critical gaps at the human-animal-environment interface.

Cervical cancer (CC) is a public health issue and one of the leading causes of morbidity and mortality among women. In Brazil, despite prevention and screening strategies, many cases are still diagnosed at advanced stages. This study aimed to analyse factors associated with advanced CC diagnosis in the state of Mato Grosso between 2002 and 2021. This is a retrospective study based on data from the Hospital Cancer Registry. A total of 1,126 women diagnosed with invasive CC (ICD-10: C53) were included. Sociodemographic, clinical and treatment access variables were analysed. Multinomial logistic regression was used to assess associations between variables and the stage at diagnosis. The results showed that 58.3% of women were diagnosed at advanced stages (III and IV). Most patients were between 35 and 59 years old, had incomplete primary education and were non-white. Squamous cell carcinoma was the predominant histological type (71.8%). Women with adenocarcinoma had a lower chance of being diagnosed at an advanced stage, while the probability of a localised diagnosis decreased with age. The high number of late CC diagnoses suggests barriers to access to screening and early treatment in Mato Grosso. Expanding screening coverage, strengthening human papillomavirus vaccination and improving oncology services are essential to reduce the incidence and mortality of the disease in the state. Identification/approval number by the Committee of Ethics in Research with Human Beings in the Health Area - CEP of the Federal University of Mato Grosso - UFMT, opinion number: 4.858.521.

Purpose This study aimed to analyze the impact of competition with successive basketball matches on mood, stress tolerance, competitive anxiety, total quality of recovery and neuromuscular performance in adolescent basketball athletes. Methods Ten youth basketball players (14.8 ± 0.5 years; 59.4 ± 9.1 kg; 173.7 ± 5.9 cm) were evaluated during a tournament with three matches in two days. Mood (M), stress tolerance (ST), competitive anxiety, total quality of recovery (TQR) and neuromuscular performance were measured before and after the matches. The session rating perceived of exertion (sRPE) was used to evaluate the internal match load (IML) during the competition. The Friedman test was used to compare the mood profile during matches and the Wilcoxon test was used to compare mood subscales pre- and post-matches. Repeated measures ANOVA compared the post-match values of sRPE, TQR, and neuromuscular variables. Results The mood profile was significantly modified during the competition and the anger subscale was different pre- and post-match 3 ( p <  0.05); somatic anxiety decreased in match 3 compared to match 1 ( p <  0.05); ST did not change across the competition ( p >  0.05); QTR reduced in match 3 compared to match 1 and 2 ( p <  0.001); there was also a reduction in speed performance ( p <  0.01), and height of the vertical jump ( p <  0.001). Conclusion The current study demonstrated that there is an impact on mood, anxiety and quality of recovery with successive basketball matches, and they also reduce neuromuscular performance in adolescent basketball players.

Background Field epidemiologists play a crucial role in addressing the complex challenges posed by emerging infectious diseases, transboundary animal diseases, and antimicrobial resistance. Despite the interdisciplinary nature of these issues, traditional field epidemiology training programs are often narrowly focused on specific sectors. To effectively confront these evolving challenges, it is imperative to equip field epidemiologists with the skills to adopt the One Health approach. However, there are neither globally accepted One Health competencies for guiding field epidemiology training programs nor standardized curricular guidance for program managers. Recognizing this gap, three international organizations joined forces to develop the Competencies for One Health Field Epidemiology framework. Methods A desktop review was conducted of the existing frontline, intermediate, and advanced field epidemiology training program curricula. Knowledge, skills, and competency (KSC) statements for frontline, intermediate and advanced levels were then defined and grouped into domains and subdomains by thematic area. An international Technical Advisory Group of 59 experts from the animal, environment, and human health sectors was convened to review the proposed statements. The framework was revised based on their feedback. KSC statements were classified into core and optional, and a prioritization tool was developed to assist countries in selecting optional KSC statements based on their specific requirements. Results The competency framework was developed and comprises KSC statements needed for field epidemiologists to successfully apply the One Health approach across the human, animal, and environment health sectors. These KSC statements are stratified by frontline, intermediate, and advanced training levels and are further categorized as core and optional; sector-specific KSC statements are also identified. Conclusions This innovative framework emerged from a multisectoral, collaborative, inclusive, and iterative process involving international animal, human, and environment health and field epidemiology training experts. Countries and regions can also use the framework to establish new, comprehensive One Health field epidemiology training programs or upgrade existing programs to incorporate the One Health approach. This framework is anticipated to pave the way for a more holistic approach to training the global community of field epidemiologists in all health sectors to meet the demands of our evolving health landscape.

Background Given the lack of published evidence on cancer incidence trends in Mato Grosso disaggregated by health regions, this study aimed to analyze the temporal trends in cancer incidence across the health regions of Mato Grosso. Methods Time series study that used data from the Population-Based Cancer Registry of Mato Grosso (2001–2018) to analyze cancer incidence trends. Age-standardized incidence rates were calculated and analyzed by year, sex, health regions, and primary cancer sites. Trends were estimated using the Joinpoint regression method, evaluating annual percentage changes (APC) and the average annual percentage change (AAPC) with a confidence interval of 95.0%. Results Among men, an increasing trend was observed for prostate cancer in the state (APC: 2.6) from 2001 to 2013, as well as in the Baixada Cuiabana (AAPC: 3.5) and Middle North (APC: 5.5) regions from 2001 to 2015, having oscillated in three other regions and decreasing for lung cancer in the state (APC: -4.2) during 2001–2009 and 2012–2018, in Baixada Cuiabana (AAPC: -2.4), and Garças Araguaia (AAPC: -3.8), and cancers of the oral cavity (AAPC: -2.3) and stomach (AAPC: -3.5) in the state. Among women, a decreasing trend was observed for cervical cancer (AAPC: -6.8) both in the state and in all regions reporting cases. A decreasing trend was also noted for breast cancer in the state (APC: -3.6) from 2001 to 2009, with an increasing trend in the Southwest (AAPC: 5.8) and Araguaia Xingu (AAPC: 5.8) regions. Lung cancer showed a decreasing trend in the state (APC: -2.7) from 2001 to 2009, while thyroid cancer exhibited an increasing trend (AAPC: 6.7). Conclusion By providing detailed information on cancer incidence trends by health region, this study underscores the need for region-specific interventions tailored to the unique magnitude of the cancer burden in each area.