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Drawing on the conceptual lens of othering, this article links public policy narratives regarding the relocation of Syrian refugees inside the United States to the establishment of a “state of exception.” Using narrative policy analysis, 36 governor statements issued in response to the 2015 terror attacks in Paris, France are catalogued as either “accepting” or “rejecting” of the Obama Administration’s refugee relocation program. This examination suggests the rejecting narratives construct a “sense of siege” in citizens driven by security fears and portrays refugees as villains. The author argues that the fear-based language in these policies, which is used to justify a state of exception, further marginalizes the status of the stateless noncitizen refugees. Utilizando el lente conceptual de la alteridad, este artículo vincula las narrativas de política pública relacionadas con la reubicación de los refugiados sirios dentro de los Estados Unidos al establecimiento de un “estado de excepción.” Utilizando el análisis de narrativa de políticas, se catalogan 36 declaraciones de gobernadores en respuesta a los ataques terroristas de 2015 en París, Francia como “tolerantes” o “intolerantes” del programa de reubicación de refugiados de la administración de Obama. El análisis sugiere que las narrativas de rechazo construyen un “sentido de asedio” en los ciudadanos motivados por miedos de seguridad y retrata a los refugiados como villanos. El autor argumenta que el lenguaje basado en el miedo en estas políticas, que se usa para justificar un estado de excepción, marginaliza aún más el estatus de los refugiados sin estado y sin ciudadanía. 本文从他者（othering）的概念视角，将关于安置美国境内叙利亚难民的公共政策叙述，和”例外状态”（state of exception）的建立联系起来。通过使用叙述性政策分析，本文将36名州长对2015年法国巴黎恐怖 袭击事件的回应分为两类，一类”接受”奥马巴政府难民安置计划，另一类则”拒绝”此计划。此调查暗示，持拒绝态度的叙述将美国公民对安全的担忧建构为一种”被包围感”（sense of siege），同时将难民描绘为罪犯。作者主张，这些政策中基于恐惧的论调（用于证明例外状态的合理性）进一步将无国籍的难民地位边缘化。

The Bush Administration's belief in the Unitary Executive has dramatically shifted the constitutional balance of power between the Executive and Legislative branches, and further degraded the role of Congress as the chief lawmaking body. The administration's broad claims of unilateral executive authority have gone beyond the limitations of the Constitution by usurping domestic and foreign affairs powers with its refusal to adhere to the Take Care Clause. This dissertation will utilize a narrative analysis methodology to explore the Bush Administration's promotion of the Unitary Executive and the administration's frequent and reckless use of signing statements as a means of undermining congressional power and total dominance of the federal bureaucracy. The purpose of this research is to investigate the narrative surrounding the Unitary Executive Theory to deconstruct claims of presidential power asserted by the Bush Administration by examining specific fears of executive power expressed by the framers of the Constitution.

Bach's purpose with this book, however, is to examine \"how state criminal trial courts regularly permit basic failures of legal process\" (2). Even judges, operating their court in an assembly-line fashion with an extreme approach to sentencing and bail, can scarcely be called justice.

The laboratory mouse shares the majority of its protein-coding genes with humans, making it the premier model organism in biomedical research, yet the two mammals differ in significant ways. To gain greater insights into both shared and species-specific transcriptional and cellular regulatory programs in the mouse, the Mouse ENCODE Consortium has mapped transcription, DNase I hypersensitivity, transcription factor binding, chromatin modifications and replication domains throughout the mouse genome in diverse cell and tissue types. By comparing with the human genome, we not only confirm substantial conservation in the newly annotated potential functional sequences, but also find a large degree of divergence of sequences involved in transcriptional regulation, chromatin state and higher order chromatin organization. Our results illuminate the wide range of evolutionary forces acting on genes and their regulatory regions, and provide a general resource for research into mammalian biology and mechanisms of human diseases. The Mouse ENCODE Consortium has mapped transcription, DNase I hypersensitivity, transcription factor binding, chromatin modifications and replication domains throughout the mouse genome in diverse cell and tissue types; these data were compared with those from human to confirm substantial conservation in the newly annotated potential functional sequences and to reveal pronounced divergence of other sequences involved in transcriptional regulation, chromatin state and higher order chromatin organization. Encyclopaedia of mouse epigenetic elements The mouse is the premier model organism in biomedical research. To gain greater insights into the shared and species-specific transcriptional and cellular regulatory programs, the Mouse ENCODE Consortium has mapped transcription, DNase I hypersensitivity, transcription factor binding, chromatin modifications and replication domains throughout the mouse genome in diverse cell and tissue types. These finding are compared with the corresponding human data to confirm substantial conservation in the newly annotated potential functional sequences, and to reveal pronounced divergence of other sequences involved in transcriptional regulation, chromatin state and higher order chromatin organization. The data and their analyses provide a valuable resource for research into mammalian biology and mechanisms of human diseases.

Despite improvements in multidisciplinary management, patients with biliary tract cancer have a poor outcome. Only 20% of patients are eligible for surgical resection with curative intent, with 5-year overall survival of less than 10% for all patients. To our knowledge, no studies have described a benefit of adjuvant therapy. We aimed to determine whether adjuvant capecitabine improved overall survival compared with observation following surgery for biliary tract cancer. This randomised, controlled, multicentre, phase 3 study was done across 44 specialist hepatopancreatobiliary centres in the UK. Eligible patients were aged 18 years or older and had histologically confirmed cholangiocarcinoma or muscle-invasive gallbladder cancer who had undergone a macroscopically complete resection (which includes liver resection, pancreatic resection, or, less commonly, both) with curative intent, and an Eastern Cooperative Oncology Group performance status of less than 2. Patients who had not completely recovered from previous surgery or who had previous chemotherapy or radiotherapy for biliary tract cancer were also excluded. Patients were randomly assigned 1:1 to receive oral capecitabine (1250 mg/m2 twice daily on days 1–14 of a 21-day cycle, for eight cycles) or observation commencing within 16 weeks of surgery. Treatment was not masked, and allocation concealment was achieved with a computerised minimisation algorithm that stratified patients by surgical centre, site of disease, resection status, and performance status. The primary outcome was overall survival. As prespecified, analyses were done by intention to treat and per protocol. This study is registered with EudraCT, number 2005-003318-13. Between March 15, 2006, and Dec 4, 2014, 447 patients were enrolled; 223 patients with biliary tract cancer resected with curative intent were randomly assigned to the capecitabine group and 224 to the observation group. The data cutoff for this analysis was March 6, 2017. The median follow-up for all patients was 60 months (IQR 37–60). In the intention-to-treat analysis, median overall survival was 51·1 months (95% CI 34·6–59·1) in the capecitabine group compared with 36·4 months (29·7–44·5) in the observation group (adjusted hazard ratio [HR] 0·81, 95% CI 0·63–1·04; p=0·097). In a protocol-specified sensitivity analysis, adjusting for minimisation factors and nodal status, grade, and gender, the overall survival HR was 0·71 (95% CI 0·55–0·92; p=0·010). In the prespecified per-protocol analysis (210 patients in the capecitabine group and 220 in the observation group), median overall survival was 53 months (95% CI 40 to not reached) in the capecitabine group and 36 months (30–44) in the observation group (adjusted HR 0·75, 95% CI 0·58–0·97; p=0·028). In the intention-to-treat analysis, median recurrence-free survival was 24·4 months (95% CI 18·6–35·9) in the capecitabine group and 17·5 months (12·0–23·8) in the observation group. In the per-protocol analysis, median recurrence-free survival was 25·9 months (95% CI 19·8–46·3) in the capecitabine group and 17·4 months (12·0–23·7) in the observation group. Adverse events were measured in the capecitabine group only, and of the 213 patients who received at least one cycle, 94 (44%) had at least one grade 3 toxicity, the most frequent of which were hand-foot syndrome in 43 (20%) patients, diarrhoea in 16 (8%) patients, and fatigue in 16 (8%) patients. One (<1%) patient had grade 4 cardiac ischaemia or infarction. Serious adverse events were observed in 47 (21%) of 223 patients in the capecitabine group and 22 (10%) of 224 patients in the observation group. No deaths were deemed to be treatment related. Although this study did not meet its primary endpoint of improving overall survival in the intention-to-treat population, the prespecified sensitivity and per-protocol analyses suggest that capecitabine can improve overall survival in patients with resected biliary tract cancer when used as adjuvant chemotherapy following surgery and could be considered as standard of care. Furthermore, the safety profile is manageable, supporting the use of capecitabine in this setting. Cancer Research UK and Roche.

Here we present a description of the UKCA StratTrop chemical mechanism, which is used in the UKESM1 Earth system model for CMIP6. The StratTrop chemical mechanism is a merger of previously well-evaluated tropospheric and stratospheric mechanisms, and we provide results from a series of bespoke integrations to assess the overall performance of the model.We find that the StratTrop scheme performs well when compared to a wide array of observations. The analysis we present here focuses on key components of atmospheric composition, namely the performance of the model to simulate ozone in the stratosphere and troposphere and constituents that are important for ozone in these regions. We find that the results obtained for tropospheric ozone and its budget terms from the use of the StratTrop mechanism are sensitive to the host model; simulations with the same chemical mechanism run in an earlier version of the MetUM host model show a range of sensitivity to emissions that the current model does not fall within.Whilst the general model performance is suitable for use in the UKESM1 CMIP6 integrations, we note some shortcomings in the scheme that future targeted studies will address.