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Launching a career in special education : your action plan for success
\"This book intends to be both a quick-start guide and a practical resource that would relate the essential skills and knowledge (setting up their classroom, behavior management tips, etc.) that a new special educator needs as they progress throughout the novice years\"-- Provided by publisher.
Book
Dynamical Backaction Magnomechanics
Dynamical backaction resulting from radiation pressure forces in optomechanical systems has proven to be a versatile tool for manipulating mechanical vibrations. Notably, dynamical backaction has resulted in the cooling of a mechanical resonator to its ground state, driving phonon lasing, the generation of entangled states, and observation of the optical-spring effect. In certain magnetic materials, mechanical vibrations can interact with magnetic excitations (magnons) via the magnetostrictive interaction, resulting in an analogous magnon-induced dynamical backaction. In this article, we directly observe the impact of magnon-induced dynamical backaction on a spherical magnetic sample’s mechanical vibrations. Moreover, dynamical backaction effects play a crucial role in many recent theoretical proposals; thus, our work provides the foundation for future experimental work pursuing many of these theoretical proposals.
Journal Article
سعيد ودراجته
\"سعيد ودراجته\" هو كتاب للأطفال كتبه ريشارد بوت وتم اقتباسه وتعريبه بواسطة أديب الإنكليزي. القصة تروي مغامرات الطفل سعيد وعلاقته بدراجته، التي تصبح رفيقته في العديد من المواقف والأحداث اليومية،\"سعيد هو طفل يحب المغامرة واكتشاف العالم من حوله. دراجته هي وسيلته المفضلة للتنقل واستكشاف الأماكن الجديدة، تدور القصة حول مغامرات سعيد بدراجته، حيث يواجه مواقف وتحديات مختلفة. هذه المواقف تعلمه دروسا مهمة في الحياة، مثل أهمية الصداقة، الالتزام بالقوانين، وقيمة العمل الجاد، القصة تهدف إلى تعليم الأطفال أهمية المثابرة والشجاعة في مواجهة التحديات. كما تعزز من فكرة الاستقلالية والمسؤولية من خلال تجارب سعيد مع دراجته\"
Book
Introduction and sustained high coverage of the HPV bivalent vaccine leads to a reduction in prevalence of HPV 16/18 and closely related HPV types
Background:
In 2008, a national human papillomavirus (HPV) immunisation programme began in Scotland for 12–13 year old females with a three-year catch-up campaign for those under the age of 18. Since 2008, three-dose uptake of bivalent vaccine in the routine cohort aged 12–13 has exceeded 90% annually, while in the catch-up cohort overall uptake is 66%.
Methods:
To monitor the impact of HPV immunisation, a programme of national surveillance was established (pre and post introduction) which included yearly sampling and HPV genotyping of women attending for cervical screening at age 20. By linking individual vaccination, screening and HPV testing records, we aim to determine the impact of the immunisation programme on circulating type-specific HPV infection particularly for four outcomes: (i) the vaccine types HPV 16 or 18 (ii) types considered to be associated with cross-protection: HPV 31, 33 or 45; (iii) all other high-risk types and (iv) any HPV.
Results:
From a total of 4679 samples tested, we demonstrate that three doses (
n
=1100) of bivalent vaccine are associated with a significant reduction in prevalence of HPV 16 and 18 from 29.8% (95% confidence interval 28.3, 31.3%) to 13.6% (95% confidence interval 11.7, 15.8%). The data also suggest cross-protection against HPV 31, 33 and 45. HPV 51 and 56 emerged as the most prevalent (10.5% and 9.6%, respectively) non-vaccine high-risk types in those vaccinated, but at lower rates than HPV 16 (25.9%) in those unvaccinated.
Conclusions:
This data demonstrate the positive impact of bivalent vaccination on the prevalence of HPV 16, 18, 31, 33 and 45 in the target population and is encouraging for countries which have achieved high-vaccine uptake.
Journal Article
Post-stroke deficits in the anticipatory control and bimanual coordination during naturalistic cooperative bimanual action
Background
Unilateral stroke leads to asymmetric deficits in movement performance; yet its effects on naturalistic bimanual actions, a key aspect of everyday functions, are understudied. Particularly, how naturalistic bimanual actions that require the two hands to cooperatively interact with each other while manipulating a single common object are planned, executed, and coordinated after stroke is not known. In the present study, we compared the anticipatory planning, execution, and coordination of force between individuals with left and right hemisphere stroke and neurotypical controls in a naturalistic bimanual common-goal task, lifting a box.
Method
Thirty-three individuals with chronic stroke (15 LCVA, 18 RCVA) and 8 neurotypical age-matched controls used both hands to lift a box fitted with force transducers under unweighted and weighted conditions. Primary dependent variables included measures of anticipation (peak grip and load force rate), execution (peak grip force, load force), and measures of within-hand (grip-load force coordination) and between-hand coordination (force rate cross-correlations). Primary analyses were performed using linear mixed effects modeling. Exploratory backward stepwise regression examined predictors of individual variability within participants with stroke.
Results
Participants with stroke, particularly the RCVA group, showed impaired scaling of grip and load force rates with the addition of weight, indicating deficits in anticipatory control. While there were no group differences in peak grip force, participants with stroke showed significant impairments in peak load force and in grip-load force coordination with specific deficits in the evolution of load force prior to object lift-off. Finally, there were differences in spatial coordination of load force rates for participants with stroke, and especially the RCVA group, as compared to controls. Unimanual motor performance of the paretic arm and hemisphere of lesion (right hemisphere) were the key predictors of impairments in anticipatory planning of grip force and bimanual coordination among participants with stroke.
Conclusions
These results suggest that individuals with stroke, particularly those with right hemisphere damage, have impairments in anticipatory planning and interlimb coordination of symmetric cooperative bimanual tasks.
Journal Article
Identifying and accounting for the Coriolis effect in satellite NO2 observations and emission estimates
Recent developments in atmospheric remote sensing from satellites have made it possible to resolve daily emission plumes from industrial point sources around the globe. Wind rotation aggregation coupled with statistical fitting is commonly used to extract emission estimates from these observations. These methods are used here to investigate how the Coriolis effect influences the trajectory of observed emission plumes as well as to assess the impact of this influence on satellite-derived emission estimates. Of the 16 industrial sites investigated, 9 showed the expected curvature for the hemisphere that they reside in, 5 showed no or negligible curvature, and 2 showed opposing or unusual curvature. The sites that showed conflicting curvature reside in topographically diverse regions, where strong meso-γ-scale (2–20 km) turbulence dominates over larger synoptic circulation patterns. For high-curvature cases, the assumption that the wind-rotated plume aggregate is symmetrically distributed across the downwind axis breaks down, which impairs the quality of statistical fitting procedures. Using annual NOx emissions from Matimba power station as a test case, not compensating for Coriolis curvature resulted in an underestimation of ∼ 9 % on average for the years 2018 to 2021. This study is the first formal observation of the Coriolis effect and its influence on satellite-derived emission estimates, and it highlights both the variability in the emission calculation methods and the need for a standardised scheme for these data to act as evidence for regulators.
Journal Article
A Prospective Nested Case-Control Study of Dengue in Infants: Rethinking and Refining the Antibody-Dependent Enhancement Dengue Hemorrhagic Fever Model
Dengue hemorrhagic fever (DHF) is the severe and life-threatening syndrome that can develop after infection with any one of the four dengue virus (DENV) serotypes. DHF occurs almost exclusively in individuals with secondary heterologous DENV infections and infants with primary DENV infections born to dengue immune mothers. The widely accepted explanation for the pathogenesis of DHF in these settings, particularly during infancy, is antibody-dependent enhancement (ADE) of DENV infection.
We conducted a prospective nested case-control study of DENV infections during infancy. Clinical data and blood samples were collected from 4,441 mothers and infants in up to two pre-illness study visits, and surveillance was performed for symptomatic and inapparent DENV infections. Pre-illness plasma samples were used to measure the associations between maternally derived anti-DENV3 antibody-neutralizing and -enhancing capacities at the time of DENV3 infection and development of infant DHF. The study captured 60 infants with DENV infections across a wide spectrum of disease severity. DENV3 was the predominant serotype among the infants with symptomatic (35/40) and inapparent (15/20) DENV infections, and 59/60 infants had a primary DENV infection. The estimated in vitro anti-DENV3 neutralizing capacity at birth positively correlated with the age of symptomatic primary DENV3 illness in infants. At the time of symptomatic DENV3 infection, essentially all infants had low anti-DENV3 neutralizing activity (50% plaque reduction neutralizing titers [PRNT(50)] 50 is associated with protection from symptomatic DENV3 illness. We did not find a significant association between DENV3 ADE activity at illness onset and the development of DHF compared with less severe symptomatic illness. The results of this study should encourage rethinking or refinement of the current ADE pathogenesis model for infant DHF and stimulate new directions of research into mechanisms responsible for the development of DHF during infancy.
ClinicalTrials.gov NCT00377754.
Journal Article
Generation of large amplitude phonon states in quantum acoustics
The development of quantum acoustics has enabled the cooling of mechanical objects to their quantum ground state, generation of mechanical Fock-states, and Schrödinger cat states. Such demonstrations have made mechanical resonators attractive candidates for quantum information processing, metrology, and macroscopic tests of quantum mechanics. However, generating large-amplitude phonon states in quantum acoustic systems has been elusive. In this work, a single superconducting qubit coupled to a high-overtone bulk acoustic resonator is used to generate a large phonon population in an acoustic mode of a high-overtone resonator. We observe extended ringdowns of the qubit, confirming the generation of a large amplitude phonon state, and also observe an upper threshold behavior, a consequence of phonon quenching predicted by our model. This work provides a key tool for generating arbitrary phonon states in circuit quantum acoustodynamics, which is important for fundamental and quantum information applications.
Quantum acoustics investigates the interaction between mechanical oscillators and superconducting qubits. Here, the authors demonstrate the generation of large-amplitude phonon states using quantum acoustics’ toolbox.
Journal Article
Laboratory Replication of Ostreid Herpes Virus (OsHV-1) Using Pacific Oyster Tissue Explants
Pacific oysters (Crassostrea or Magallana gigas) are one of the most economically important aquaculture species globally. Over the past two decades, ostreid herpesvirus (OsHV-1) has become a major pathogen of cultured Pacific oysters, resulting in widespread mortality with a global distribution. Experimental use of OsHV-1 is challenging for many reasons, including both complexity of host–pathogen dynamics and a lack of functioning model systems. The goal of this study was to improve the tools available for working with OsHV-1 in both whole animals and in tissue explants established from oysters maintained in controlled laboratory conditions. Tissue explants were taken from oysters originating from two different sources that have different levels of mortality in experimental OsHV-1 infections and were exposed to OsHV-1. A whole-animal infection experiment was run concurrently as a comparison. Quantitative PCR and electron microscopy were used to confirm that the explants were capable of replicating OsHV-1. Furthermore, the quantitative PCR results suggest that the source of the oysters was significant in determining the outcome of infection in the explants, supporting the validity of the explant model for OsHV-1 infection. This tissue explant approach for studying OsHV-1 allows for the control of confounding factors in the disease outcome that is not possible in whole-animal experiments, providing a new tool for the study of OsHV-1 in Pacific oysters.
Journal Article
Diagnosing air quality changes in the UK during the COVID-19 lockdown using TROPOMI and GEOS-Chem
The dramatic and sudden reduction in anthropogenic activity due to lockdown measures in the UK in response to the COVID-19 outbreak has resulted in a concerted effort to estimate local and regional changes in air quality, though changes in underlying emissions remain uncertain. Here we combine satellite observations of tropospheric NO 2 from TROPOspheric Monitoring Instrument and the Goddard Earth Observing System (GEOS)-Chem 3D chemical transport model to estimate that NO x emissions declined nationwide by ∼20% during the lockdown (23 March to 31 May 2020). Regionally, these range from 22% to 23% in the western portion of the country to 29% in the southeast and Manchester, and >40% in London. We apply a uniform 20% lockdown period emission reduction to GEOS-Chem anthropogenic emissions over the UK to determine that decline in lockdown emissions led to a national decline in PM 2.5 of 1.1 μ g m −3 , ranging from 0.6 μ g m −3 in Scotland to 2 μ g m −3 in the southwest. The decline in emissions in cities (>40%) is greater than the national average and causes an increase in ozone of ∼2 ppbv in London and Manchester. The change in ozone and PM 2.5 concentrations due to emission reductions alone is about half the total change from 2019 to 2020. This emphasizes the need to account for emissions and other factors, in particular meteorology, in future air pollution abatement strategies and regulatory action.
Journal Article